The tumour suppressor CYLD regulates the p53 DNA damage response

CYLD is a deubiquitinase known to act as a tumour suppressor in different models of carcinogenesis. Here, the authors show that CYLD suppresses carcinogen-induced tumorigenesis by deubiquitinating p53 and promoting its stabilization and activation in response to DNA damage.

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Autores principales:	Vanesa Fernández-Majada, Patrick-Simon Welz, Maria A. Ermolaeva, Michael Schell, Alexander Adam, Felix Dietlein, David Komander, Reinhard Büttner, Roman K. Thomas, Björn Schumacher, Manolis Pasparakis
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/79bd90df0bdb446e800325e92d9eaee1
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spelling	oai:doaj.org-article:79bd90df0bdb446e800325e92d9eaee12021-12-02T17:31:19ZThe tumour suppressor CYLD regulates the p53 DNA damage response10.1038/ncomms125082041-1723https://doaj.org/article/79bd90df0bdb446e800325e92d9eaee12016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12508https://doaj.org/toc/2041-1723CYLD is a deubiquitinase known to act as a tumour suppressor in different models of carcinogenesis. Here, the authors show that CYLD suppresses carcinogen-induced tumorigenesis by deubiquitinating p53 and promoting its stabilization and activation in response to DNA damage.Vanesa Fernández-MajadaPatrick-Simon WelzMaria A. ErmolaevaMichael SchellAlexander AdamFelix DietleinDavid KomanderReinhard BüttnerRoman K. ThomasBjörn SchumacherManolis PasparakisNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vanesa Fernández-Majada Patrick-Simon Welz Maria A. Ermolaeva Michael Schell Alexander Adam Felix Dietlein David Komander Reinhard Büttner Roman K. Thomas Björn Schumacher Manolis Pasparakis The tumour suppressor CYLD regulates the p53 DNA damage response
description	CYLD is a deubiquitinase known to act as a tumour suppressor in different models of carcinogenesis. Here, the authors show that CYLD suppresses carcinogen-induced tumorigenesis by deubiquitinating p53 and promoting its stabilization and activation in response to DNA damage.
format	article
author	Vanesa Fernández-Majada Patrick-Simon Welz Maria A. Ermolaeva Michael Schell Alexander Adam Felix Dietlein David Komander Reinhard Büttner Roman K. Thomas Björn Schumacher Manolis Pasparakis
author_facet	Vanesa Fernández-Majada Patrick-Simon Welz Maria A. Ermolaeva Michael Schell Alexander Adam Felix Dietlein David Komander Reinhard Büttner Roman K. Thomas Björn Schumacher Manolis Pasparakis
author_sort	Vanesa Fernández-Majada
title	The tumour suppressor CYLD regulates the p53 DNA damage response
title_short	The tumour suppressor CYLD regulates the p53 DNA damage response
title_full	The tumour suppressor CYLD regulates the p53 DNA damage response
title_fullStr	The tumour suppressor CYLD regulates the p53 DNA damage response
title_full_unstemmed	The tumour suppressor CYLD regulates the p53 DNA damage response
title_sort	tumour suppressor cyld regulates the p53 dna damage response
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/79bd90df0bdb446e800325e92d9eaee1
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The tumour suppressor CYLD regulates the p53 DNA damage response

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