Nonlinear collision between propagating waves in mouse somatosensory cortex

Abstract How does cellular organization shape the spatio-temporal patterns of activity in the cortex while processing sensory information? After measuring the propagation of activity in the mouse primary somatosensory cortex (S1) in response to single whisker deflections with Voltage Sensitive Dye (...

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Autores principales:	M. Di Volo, I. Férézou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/79bde5071bca4cfdae7fa27e473936c5
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spelling	oai:doaj.org-article:79bde5071bca4cfdae7fa27e473936c52021-12-02T16:56:48ZNonlinear collision between propagating waves in mouse somatosensory cortex10.1038/s41598-021-99057-72045-2322https://doaj.org/article/79bde5071bca4cfdae7fa27e473936c52021-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-99057-7https://doaj.org/toc/2045-2322Abstract How does cellular organization shape the spatio-temporal patterns of activity in the cortex while processing sensory information? After measuring the propagation of activity in the mouse primary somatosensory cortex (S1) in response to single whisker deflections with Voltage Sensitive Dye (VSD) imaging, we developed a two dimensional model of S1. We designed an inference method to reconstruct model parameters from VSD data, revealing that a spatially heterogeneous organization of synaptic strengths between pyramidal neurons in S1 is likely to be responsible for the heterogeneous spatio-temporal patterns of activity measured experimentally. The model shows that, for strong enough excitatory cortical interactions, whisker deflections generate a propagating wave in S1. Finally, we report that two consecutive stimuli activating different spatial locations in S1 generate two waves which collide sub-linearly, giving rise to a suppressive wave. In the inferred model, the suppressive wave is explained by a lower sensitivity to external perturbations of neural networks during activated states.M. Di VoloI. FérézouNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q M. Di Volo I. Férézou Nonlinear collision between propagating waves in mouse somatosensory cortex
description	Abstract How does cellular organization shape the spatio-temporal patterns of activity in the cortex while processing sensory information? After measuring the propagation of activity in the mouse primary somatosensory cortex (S1) in response to single whisker deflections with Voltage Sensitive Dye (VSD) imaging, we developed a two dimensional model of S1. We designed an inference method to reconstruct model parameters from VSD data, revealing that a spatially heterogeneous organization of synaptic strengths between pyramidal neurons in S1 is likely to be responsible for the heterogeneous spatio-temporal patterns of activity measured experimentally. The model shows that, for strong enough excitatory cortical interactions, whisker deflections generate a propagating wave in S1. Finally, we report that two consecutive stimuli activating different spatial locations in S1 generate two waves which collide sub-linearly, giving rise to a suppressive wave. In the inferred model, the suppressive wave is explained by a lower sensitivity to external perturbations of neural networks during activated states.
format	article
author	M. Di Volo I. Férézou
author_facet	M. Di Volo I. Férézou
author_sort	M. Di Volo
title	Nonlinear collision between propagating waves in mouse somatosensory cortex
title_short	Nonlinear collision between propagating waves in mouse somatosensory cortex
title_full	Nonlinear collision between propagating waves in mouse somatosensory cortex
title_fullStr	Nonlinear collision between propagating waves in mouse somatosensory cortex
title_full_unstemmed	Nonlinear collision between propagating waves in mouse somatosensory cortex
title_sort	nonlinear collision between propagating waves in mouse somatosensory cortex
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/79bde5071bca4cfdae7fa27e473936c5
work_keys_str_mv	AT mdivolo nonlinearcollisionbetweenpropagatingwavesinmousesomatosensorycortex AT iferezou nonlinearcollisionbetweenpropagatingwavesinmousesomatosensorycortex
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Nonlinear collision between propagating waves in mouse somatosensory cortex

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