Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome

The double-stranded DNA receptor AIM2 is able to sense the environmental pollutant perfluorooctane sulfonate, a prototypical perfluoro-alkyl substrate. Activation of the AIM2 pathway leads to inflammation and tissue damage via IL-1β secretion and pyroptosis of affected innate immune cells.

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Autores principales:	Li-Qiu Wang, Tao Liu, Shuai Yang, Lin Sun, Zhi-Yao Zhao, Li-Yue Li, Yuan-Chu She, Yan-Yan Zheng, Xiao-Yan Ye, Qing Bao, Guang-Hui Dong, Chun-Wei Li, Jun Cui
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/79bf5e4585bd4a3daeb1b694c9b9e1b5
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spelling	oai:doaj.org-article:79bf5e4585bd4a3daeb1b694c9b9e1b52021-12-02T16:51:19ZPerfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome10.1038/s41467-021-23201-02041-1723https://doaj.org/article/79bf5e4585bd4a3daeb1b694c9b9e1b52021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23201-0https://doaj.org/toc/2041-1723The double-stranded DNA receptor AIM2 is able to sense the environmental pollutant perfluorooctane sulfonate, a prototypical perfluoro-alkyl substrate. Activation of the AIM2 pathway leads to inflammation and tissue damage via IL-1β secretion and pyroptosis of affected innate immune cells.Li-Qiu WangTao LiuShuai YangLin SunZhi-Yao ZhaoLi-Yue LiYuan-Chu SheYan-Yan ZhengXiao-Yan YeQing BaoGuang-Hui DongChun-Wei LiJun CuiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Li-Qiu Wang Tao Liu Shuai Yang Lin Sun Zhi-Yao Zhao Li-Yue Li Yuan-Chu She Yan-Yan Zheng Xiao-Yan Ye Qing Bao Guang-Hui Dong Chun-Wei Li Jun Cui Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
description	The double-stranded DNA receptor AIM2 is able to sense the environmental pollutant perfluorooctane sulfonate, a prototypical perfluoro-alkyl substrate. Activation of the AIM2 pathway leads to inflammation and tissue damage via IL-1β secretion and pyroptosis of affected innate immune cells.
format	article
author	Li-Qiu Wang Tao Liu Shuai Yang Lin Sun Zhi-Yao Zhao Li-Yue Li Yuan-Chu She Yan-Yan Zheng Xiao-Yan Ye Qing Bao Guang-Hui Dong Chun-Wei Li Jun Cui
author_facet	Li-Qiu Wang Tao Liu Shuai Yang Lin Sun Zhi-Yao Zhao Li-Yue Li Yuan-Chu She Yan-Yan Zheng Xiao-Yan Ye Qing Bao Guang-Hui Dong Chun-Wei Li Jun Cui
author_sort	Li-Qiu Wang
title	Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
title_short	Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
title_full	Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
title_fullStr	Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
title_full_unstemmed	Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome
title_sort	perfluoroalkyl substance pollutants activate the innate immune system through the aim2 inflammasome
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/79bf5e4585bd4a3daeb1b694c9b9e1b5
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Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome

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