ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer

Although Krüppel-associated box zinc finger proteins (KZFPs) were found to mostly repress transposable elements, recent studies found that KFZPs also play other roles in cells. Here, the authors provide evidence that the KZFP ZFP30 promotes adipogenesis by targeting and activating a retrotransposon-...

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Autores principales:	Wanze Chen, Petra C. Schwalie, Eugenia V. Pankevich, Carine Gubelmann, Sunil K. Raghav, Riccardo Dainese, Marco Cassano, Michael Imbeault, Suk Min Jang, Julie Russeil, Tenagne Delessa, Julien Duc, Didier Trono, Christian Wolfrum, Bart Deplancke
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/79c0840feab948d880b74c9fb3a62bf1
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spelling	oai:doaj.org-article:79c0840feab948d880b74c9fb3a62bf12021-12-02T15:35:17ZZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer10.1038/s41467-019-09803-92041-1723https://doaj.org/article/79c0840feab948d880b74c9fb3a62bf12019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09803-9https://doaj.org/toc/2041-1723Although Krüppel-associated box zinc finger proteins (KZFPs) were found to mostly repress transposable elements, recent studies found that KFZPs also play other roles in cells. Here, the authors provide evidence that the KZFP ZFP30 promotes adipogenesis by targeting and activating a retrotransposon-derived Pparg2 enhancer in cooperation with co-regulator KRAB-associated protein 1 (KAP1).Wanze ChenPetra C. SchwalieEugenia V. PankevichCarine GubelmannSunil K. RaghavRiccardo DaineseMarco CassanoMichael ImbeaultSuk Min JangJulie RusseilTenagne DelessaJulien DucDidier TronoChristian WolfrumBart DeplanckeNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wanze Chen Petra C. Schwalie Eugenia V. Pankevich Carine Gubelmann Sunil K. Raghav Riccardo Dainese Marco Cassano Michael Imbeault Suk Min Jang Julie Russeil Tenagne Delessa Julien Duc Didier Trono Christian Wolfrum Bart Deplancke ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer
description	Although Krüppel-associated box zinc finger proteins (KZFPs) were found to mostly repress transposable elements, recent studies found that KFZPs also play other roles in cells. Here, the authors provide evidence that the KZFP ZFP30 promotes adipogenesis by targeting and activating a retrotransposon-derived Pparg2 enhancer in cooperation with co-regulator KRAB-associated protein 1 (KAP1).
format	article
author	Wanze Chen Petra C. Schwalie Eugenia V. Pankevich Carine Gubelmann Sunil K. Raghav Riccardo Dainese Marco Cassano Michael Imbeault Suk Min Jang Julie Russeil Tenagne Delessa Julien Duc Didier Trono Christian Wolfrum Bart Deplancke
author_facet	Wanze Chen Petra C. Schwalie Eugenia V. Pankevich Carine Gubelmann Sunil K. Raghav Riccardo Dainese Marco Cassano Michael Imbeault Suk Min Jang Julie Russeil Tenagne Delessa Julien Duc Didier Trono Christian Wolfrum Bart Deplancke
author_sort	Wanze Chen
title	ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer
title_short	ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer
title_full	ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer
title_fullStr	ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer
title_full_unstemmed	ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer
title_sort	zfp30 promotes adipogenesis through the kap1-mediated activation of a retrotransposon-derived pparg2 enhancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/79c0840feab948d880b74c9fb3a62bf1
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ZFP30 promotes adipogenesis through the KAP1-mediated activation of a retrotransposon-derived Pparg2 enhancer

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