Association of sex differences in dementia risk factors with sex differences in memory decline in a population-based cohort spanning 20–76 years

Abstract Sex differences in late-life memory decline may be explained by sex differences in dementia risk factors. Episodic memory and dementia risk factors were assessed in young, middle-aged and older adults over 12 years in a population-based sample (N = 7485). For men in midlife and old age, phy...

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Autores principales:	Kaarin J. Anstey, Ruth Peters, Moyra E. Mortby, Kim M. Kiely, Ranmalee Eramudugolla, Nicolas Cherbuin, Md Hamidul Huque, Roger A. Dixon
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/79c6baa5fcdd4d10a5db07a72460733b
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spelling	oai:doaj.org-article:79c6baa5fcdd4d10a5db07a72460733b2021-12-02T14:37:15ZAssociation of sex differences in dementia risk factors with sex differences in memory decline in a population-based cohort spanning 20–76 years10.1038/s41598-021-86397-72045-2322https://doaj.org/article/79c6baa5fcdd4d10a5db07a72460733b2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86397-7https://doaj.org/toc/2045-2322Abstract Sex differences in late-life memory decline may be explained by sex differences in dementia risk factors. Episodic memory and dementia risk factors were assessed in young, middle-aged and older adults over 12 years in a population-based sample (N = 7485). For men in midlife and old age, physical, cognitive and social activities were associated with less memory decline, and financial hardship was associated with more. APOE e4 and vascular risk factors were associated with memory decline for women in midlife. Depression, cognitive and physical activity were associated with memory change in older women. Incident midlife hypertension (β = − 0.48, 95% CI − 0.87, − 0.09, p = 0.02) was associated with greater memory decline in women and incident late-life stroke accounted for greater memory decline in men (β = − 0.56, 95% CI − 1.12, − 0.01), p = 0.05). Women have fewer modifiable risk factors than men. Stroke and hypertension explained sex differences in memory decline for men and women respectively.Kaarin J. AnsteyRuth PetersMoyra E. MortbyKim M. KielyRanmalee EramudugollaNicolas CherbuinMd Hamidul HuqueRoger A. DixonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kaarin J. Anstey Ruth Peters Moyra E. Mortby Kim M. Kiely Ranmalee Eramudugolla Nicolas Cherbuin Md Hamidul Huque Roger A. Dixon Association of sex differences in dementia risk factors with sex differences in memory decline in a population-based cohort spanning 20–76 years
description	Abstract Sex differences in late-life memory decline may be explained by sex differences in dementia risk factors. Episodic memory and dementia risk factors were assessed in young, middle-aged and older adults over 12 years in a population-based sample (N = 7485). For men in midlife and old age, physical, cognitive and social activities were associated with less memory decline, and financial hardship was associated with more. APOE e4 and vascular risk factors were associated with memory decline for women in midlife. Depression, cognitive and physical activity were associated with memory change in older women. Incident midlife hypertension (β = − 0.48, 95% CI − 0.87, − 0.09, p = 0.02) was associated with greater memory decline in women and incident late-life stroke accounted for greater memory decline in men (β = − 0.56, 95% CI − 1.12, − 0.01), p = 0.05). Women have fewer modifiable risk factors than men. Stroke and hypertension explained sex differences in memory decline for men and women respectively.
format	article
author	Kaarin J. Anstey Ruth Peters Moyra E. Mortby Kim M. Kiely Ranmalee Eramudugolla Nicolas Cherbuin Md Hamidul Huque Roger A. Dixon
author_facet	Kaarin J. Anstey Ruth Peters Moyra E. Mortby Kim M. Kiely Ranmalee Eramudugolla Nicolas Cherbuin Md Hamidul Huque Roger A. Dixon
author_sort	Kaarin J. Anstey
title	Association of sex differences in dementia risk factors with sex differences in memory decline in a population-based cohort spanning 20–76 years
title_short	Association of sex differences in dementia risk factors with sex differences in memory decline in a population-based cohort spanning 20–76 years
title_full	Association of sex differences in dementia risk factors with sex differences in memory decline in a population-based cohort spanning 20–76 years
title_fullStr	Association of sex differences in dementia risk factors with sex differences in memory decline in a population-based cohort spanning 20–76 years
title_full_unstemmed	Association of sex differences in dementia risk factors with sex differences in memory decline in a population-based cohort spanning 20–76 years
title_sort	association of sex differences in dementia risk factors with sex differences in memory decline in a population-based cohort spanning 20–76 years
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/79c6baa5fcdd4d10a5db07a72460733b
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Association of sex differences in dementia risk factors with sex differences in memory decline in a population-based cohort spanning 20–76 years

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