Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay

Gene expression is regulated by a range of mechanisms, including post-translational modifications such as phosphorylation. Here the authors present evidence for a feedback mechanism whereby hyperphosphorylation of UPF1 in response to delays in nonsense-mediated decay enhances recruitment of mRNA dec...

Description complète

Enregistré dans:

Détails bibliographiques
Auteurs principaux:	Sébastien Durand, Tobias M. Franks, Jens Lykke-Andersen
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2016
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/79ca1cb3a60a4deb9eea14b411371127
Tags:	Ajouter un tag Pas de tags, Soyez le premier à ajouter un tag!

id	oai:doaj.org-article:79ca1cb3a60a4deb9eea14b411371127
record_format	dspace
spelling	oai:doaj.org-article:79ca1cb3a60a4deb9eea14b4113711272021-12-02T15:35:45ZHyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay10.1038/ncomms124342041-1723https://doaj.org/article/79ca1cb3a60a4deb9eea14b4113711272016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12434https://doaj.org/toc/2041-1723Gene expression is regulated by a range of mechanisms, including post-translational modifications such as phosphorylation. Here the authors present evidence for a feedback mechanism whereby hyperphosphorylation of UPF1 in response to delays in nonsense-mediated decay enhances recruitment of mRNA decay machinery.Sébastien DurandTobias M. FranksJens Lykke-AndersenNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Sébastien Durand Tobias M. Franks Jens Lykke-Andersen Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay
description	Gene expression is regulated by a range of mechanisms, including post-translational modifications such as phosphorylation. Here the authors present evidence for a feedback mechanism whereby hyperphosphorylation of UPF1 in response to delays in nonsense-mediated decay enhances recruitment of mRNA decay machinery.
format	article
author	Sébastien Durand Tobias M. Franks Jens Lykke-Andersen
author_facet	Sébastien Durand Tobias M. Franks Jens Lykke-Andersen
author_sort	Sébastien Durand
title	Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay
title_short	Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay
title_full	Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay
title_fullStr	Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay
title_full_unstemmed	Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay
title_sort	hyperphosphorylation amplifies upf1 activity to resolve stalls in nonsense-mediated mrna decay
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/79ca1cb3a60a4deb9eea14b411371127
work_keys_str_mv	AT sebastiendurand hyperphosphorylationamplifiesupf1activitytoresolvestallsinnonsensemediatedmrnadecay AT tobiasmfranks hyperphosphorylationamplifiesupf1activitytoresolvestallsinnonsensemediatedmrnadecay AT jenslykkeandersen hyperphosphorylationamplifiesupf1activitytoresolvestallsinnonsensemediatedmrnadecay
_version_	1718386483186892800

Hyperphosphorylation amplifies UPF1 activity to resolve stalls in nonsense-mediated mRNA decay

Documents similaires