Dissecting the Biological Relevance and Clinical Impact of lncRNA MIAT in Multiple Myeloma

The biological impact of long non-coding RNAs (lncRNAs) in multiple myeloma (MM) is becoming an essential aspect of the investigation, which may contribute to understanding the disease’s complex pathobiology, providing novel potential therapeutic targets. Herein, we investigated the expression patte...

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Autores principales:	Katia Todoerti, Domenica Ronchetti, Noemi Puccio, Ilaria Silvestris, Vanessa Favasuli, Nicola Amodio, Massimo Gentile, Fortunato Morabito, Antonino Neri, Elisa Taiana
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	MIAT multiple myeloma bortezomib Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/79cdff066f9c42c5b17919fcd223b0ab
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spelling	oai:doaj.org-article:79cdff066f9c42c5b17919fcd223b0ab2021-11-11T15:33:49ZDissecting the Biological Relevance and Clinical Impact of lncRNA MIAT in Multiple Myeloma10.3390/cancers132155182072-6694https://doaj.org/article/79cdff066f9c42c5b17919fcd223b0ab2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5518https://doaj.org/toc/2072-6694The biological impact of long non-coding RNAs (lncRNAs) in multiple myeloma (MM) is becoming an essential aspect of the investigation, which may contribute to understanding the disease’s complex pathobiology, providing novel potential therapeutic targets. Herein, we investigated the expression pattern and the clinical relevance of the lncRNA MIAT in MM, taking advantage of the publicly available CoMMpass database. MIAT expression in MM is highly heterogeneous and significantly associated with specific molecular lesions frequently occurring in MM. Transcriptome analyses of MM PCs from patients included in the CoMMpass database indicated a potential involvement of MIAT in different signaling pathways and ribosome biogenesis and assembly. These findings suggest that MIAT deregulation may play a pathogenetic role in MM by affecting both proliferation pathways and, indirectly, the translational process. Although MIAT expression levels seem not to be significantly associated with clinical outcome in multivariate analyses, high MIAT expression levels are associated with bortezomib resistance, this suggesting that MIAT targeting could overcome drug resistance in MM. These findings strongly prompt for further studies investigating the significance of MIAT in MM.Katia TodoertiDomenica RonchettiNoemi PuccioIlaria SilvestrisVanessa FavasuliNicola AmodioMassimo GentileFortunato MorabitoAntonino NeriElisa TaianaMDPI AGarticleMIATmultiple myelomabortezomibNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5518, p 5518 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	MIAT multiple myeloma bortezomib Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	MIAT multiple myeloma bortezomib Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Katia Todoerti Domenica Ronchetti Noemi Puccio Ilaria Silvestris Vanessa Favasuli Nicola Amodio Massimo Gentile Fortunato Morabito Antonino Neri Elisa Taiana Dissecting the Biological Relevance and Clinical Impact of lncRNA MIAT in Multiple Myeloma
description	The biological impact of long non-coding RNAs (lncRNAs) in multiple myeloma (MM) is becoming an essential aspect of the investigation, which may contribute to understanding the disease’s complex pathobiology, providing novel potential therapeutic targets. Herein, we investigated the expression pattern and the clinical relevance of the lncRNA MIAT in MM, taking advantage of the publicly available CoMMpass database. MIAT expression in MM is highly heterogeneous and significantly associated with specific molecular lesions frequently occurring in MM. Transcriptome analyses of MM PCs from patients included in the CoMMpass database indicated a potential involvement of MIAT in different signaling pathways and ribosome biogenesis and assembly. These findings suggest that MIAT deregulation may play a pathogenetic role in MM by affecting both proliferation pathways and, indirectly, the translational process. Although MIAT expression levels seem not to be significantly associated with clinical outcome in multivariate analyses, high MIAT expression levels are associated with bortezomib resistance, this suggesting that MIAT targeting could overcome drug resistance in MM. These findings strongly prompt for further studies investigating the significance of MIAT in MM.
format	article
author	Katia Todoerti Domenica Ronchetti Noemi Puccio Ilaria Silvestris Vanessa Favasuli Nicola Amodio Massimo Gentile Fortunato Morabito Antonino Neri Elisa Taiana
author_facet	Katia Todoerti Domenica Ronchetti Noemi Puccio Ilaria Silvestris Vanessa Favasuli Nicola Amodio Massimo Gentile Fortunato Morabito Antonino Neri Elisa Taiana
author_sort	Katia Todoerti
title	Dissecting the Biological Relevance and Clinical Impact of lncRNA MIAT in Multiple Myeloma
title_short	Dissecting the Biological Relevance and Clinical Impact of lncRNA MIAT in Multiple Myeloma
title_full	Dissecting the Biological Relevance and Clinical Impact of lncRNA MIAT in Multiple Myeloma
title_fullStr	Dissecting the Biological Relevance and Clinical Impact of lncRNA MIAT in Multiple Myeloma
title_full_unstemmed	Dissecting the Biological Relevance and Clinical Impact of lncRNA MIAT in Multiple Myeloma
title_sort	dissecting the biological relevance and clinical impact of lncrna miat in multiple myeloma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/79cdff066f9c42c5b17919fcd223b0ab
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Dissecting the Biological Relevance and Clinical Impact of lncRNA MIAT in Multiple Myeloma

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