Bone Regeneration of a 3D-Printed Alloplastic and Particulate Xenogenic Graft with rhBMP-2

This study aimed to evaluate the bone regeneration capacity of a customized alloplastic material and xenograft with recombinant human bone morphogenetic protein-2 (rhBMP-2). We prepared hydroxyapatite (HA)/tricalcium phosphate (TCP) pure ceramic bone blocks made using a 3D printing system and added...

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Autores principales:	Ji-In Ryu, Byoung-Eun Yang, Sang-Min Yi, Hyo Geun Choi, Sung-Woon On, Seok Jin Hong, Ho-Kyung Lim, Soo-Hwan Byun
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	3D printing hydroxyapatites beta-tricalcium phosphate HA/TCP recombinant human bone morphogenetic protein-2 Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/79cf9d3b9a2f4c03b92b6fe3799ecce6
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spelling	oai:doaj.org-article:79cf9d3b9a2f4c03b92b6fe3799ecce62021-11-25T17:57:26ZBone Regeneration of a 3D-Printed Alloplastic and Particulate Xenogenic Graft with rhBMP-210.3390/ijms2222125181422-00671661-6596https://doaj.org/article/79cf9d3b9a2f4c03b92b6fe3799ecce62021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12518https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067This study aimed to evaluate the bone regeneration capacity of a customized alloplastic material and xenograft with recombinant human bone morphogenetic protein-2 (rhBMP-2). We prepared hydroxyapatite (HA)/tricalcium phosphate (TCP) pure ceramic bone blocks made using a 3D printing system and added rhBMP-2 to both materials. In eight beagle dogs, a total of 32 defects were created on the lower jaws. The defective sites of the negative control group were left untreated (N group; 8 defects), and those in the positive control group were filled with particle-type Bio-Oss (P group; 12 defects). The defect sites in the experimental group were filled with 3D-printed synthetic bone blocks (3D group; 12 defects). Radiographic and histological evaluations were performed after healing periods of 6 and 12 weeks and showed no significant difference in new bone formation and total bone between the P and 3D groups. The 3D-printed custom HA/TCP graft with rhBMP-2 showed bone regeneration effects similar to that of particulate Bio-Oss with rhBMP-2. Through further study and development, the application of 3D-printed customized alloplastic grafts will be extended to various fields of bone regeneration.Ji-In RyuByoung-Eun YangSang-Min YiHyo Geun ChoiSung-Woon OnSeok Jin HongHo-Kyung LimSoo-Hwan ByunMDPI AGarticle3D printinghydroxyapatitesbeta-tricalcium phosphateHA/TCPrecombinant human bone morphogenetic protein-2Biology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12518, p 12518 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	3D printing hydroxyapatites beta-tricalcium phosphate HA/TCP recombinant human bone morphogenetic protein-2 Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	3D printing hydroxyapatites beta-tricalcium phosphate HA/TCP recombinant human bone morphogenetic protein-2 Biology (General) QH301-705.5 Chemistry QD1-999 Ji-In Ryu Byoung-Eun Yang Sang-Min Yi Hyo Geun Choi Sung-Woon On Seok Jin Hong Ho-Kyung Lim Soo-Hwan Byun Bone Regeneration of a 3D-Printed Alloplastic and Particulate Xenogenic Graft with rhBMP-2
description	This study aimed to evaluate the bone regeneration capacity of a customized alloplastic material and xenograft with recombinant human bone morphogenetic protein-2 (rhBMP-2). We prepared hydroxyapatite (HA)/tricalcium phosphate (TCP) pure ceramic bone blocks made using a 3D printing system and added rhBMP-2 to both materials. In eight beagle dogs, a total of 32 defects were created on the lower jaws. The defective sites of the negative control group were left untreated (N group; 8 defects), and those in the positive control group were filled with particle-type Bio-Oss (P group; 12 defects). The defect sites in the experimental group were filled with 3D-printed synthetic bone blocks (3D group; 12 defects). Radiographic and histological evaluations were performed after healing periods of 6 and 12 weeks and showed no significant difference in new bone formation and total bone between the P and 3D groups. The 3D-printed custom HA/TCP graft with rhBMP-2 showed bone regeneration effects similar to that of particulate Bio-Oss with rhBMP-2. Through further study and development, the application of 3D-printed customized alloplastic grafts will be extended to various fields of bone regeneration.
format	article
author	Ji-In Ryu Byoung-Eun Yang Sang-Min Yi Hyo Geun Choi Sung-Woon On Seok Jin Hong Ho-Kyung Lim Soo-Hwan Byun
author_facet	Ji-In Ryu Byoung-Eun Yang Sang-Min Yi Hyo Geun Choi Sung-Woon On Seok Jin Hong Ho-Kyung Lim Soo-Hwan Byun
author_sort	Ji-In Ryu
title	Bone Regeneration of a 3D-Printed Alloplastic and Particulate Xenogenic Graft with rhBMP-2
title_short	Bone Regeneration of a 3D-Printed Alloplastic and Particulate Xenogenic Graft with rhBMP-2
title_full	Bone Regeneration of a 3D-Printed Alloplastic and Particulate Xenogenic Graft with rhBMP-2
title_fullStr	Bone Regeneration of a 3D-Printed Alloplastic and Particulate Xenogenic Graft with rhBMP-2
title_full_unstemmed	Bone Regeneration of a 3D-Printed Alloplastic and Particulate Xenogenic Graft with rhBMP-2
title_sort	bone regeneration of a 3d-printed alloplastic and particulate xenogenic graft with rhbmp-2
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/79cf9d3b9a2f4c03b92b6fe3799ecce6
work_keys_str_mv	AT jiinryu boneregenerationofa3dprintedalloplasticandparticulatexenogenicgraftwithrhbmp2 AT byoungeunyang boneregenerationofa3dprintedalloplasticandparticulatexenogenicgraftwithrhbmp2 AT sangminyi boneregenerationofa3dprintedalloplasticandparticulatexenogenicgraftwithrhbmp2 AT hyogeunchoi boneregenerationofa3dprintedalloplasticandparticulatexenogenicgraftwithrhbmp2 AT sungwoonon boneregenerationofa3dprintedalloplasticandparticulatexenogenicgraftwithrhbmp2 AT seokjinhong boneregenerationofa3dprintedalloplasticandparticulatexenogenicgraftwithrhbmp2 AT hokyunglim boneregenerationofa3dprintedalloplasticandparticulatexenogenicgraftwithrhbmp2 AT soohwanbyun boneregenerationofa3dprintedalloplasticandparticulatexenogenicgraftwithrhbmp2
_version_	1718411811008544768

Bone Regeneration of a 3D-Printed Alloplastic and Particulate Xenogenic Graft with rhBMP-2

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