The CKD bowel health study: understanding the bowel health and gastrointestinal symptom management in patients with chronic kidney disease: a mixed-methods observational longitudinal study (protocol)

Abstract Background Gastro-intestinal (GI) intolerance is a frequently reported outcome in patients with kidney failure receiving maintenance dialysis and those who have received kidney transplants. Symptoms of GI intolerance (diarrhoea, constipation, bloating, abdominal pain, heart burn, and reflux...

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Autores principales:	Tess E. Cooper, Amy Dalton, Anh Kieu, Martin Howell, Sumedh Jayanti, Rabia Khalid, Wai H. Lim, Nicole Scholes-Robertson, Jonathan C. Craig, Armando Teixeira-Pinto, Michael J. Bourke, Allison Tong, Germaine Wong
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Chronic kidney disease Kidney transplant Dialysis Gut microbiome Uremic toxins Gut microbiota Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/79d2def4429349b5bf22e3b95243a460
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spelling	oai:doaj.org-article:79d2def4429349b5bf22e3b95243a4602021-11-28T12:41:27ZThe CKD bowel health study: understanding the bowel health and gastrointestinal symptom management in patients with chronic kidney disease: a mixed-methods observational longitudinal study (protocol)10.1186/s12882-021-02600-x1471-2369https://doaj.org/article/79d2def4429349b5bf22e3b95243a4602021-11-01T00:00:00Zhttps://doi.org/10.1186/s12882-021-02600-xhttps://doaj.org/toc/1471-2369Abstract Background Gastro-intestinal (GI) intolerance is a frequently reported outcome in patients with kidney failure receiving maintenance dialysis and those who have received kidney transplants. Symptoms of GI intolerance (diarrhoea, constipation, bloating, abdominal pain, heart burn, and reflux) are associated with significant reduction in quality of life, morbidity, and increased used of healthcare resources. Having chronic kidney disease (CKD), together with related changes in diet and medication, may alter the gut microbiota and the microbial-derived uraemic metabolites that accumulate in kidney failure, and contribute to various complications including chronic diarrhoea, opportunistic infections, and drug-related colitis. Despite the high disease burden among patients with kidney replacement therapies, GI symptoms are often under-recognised and, consequently limited resources and strategies are devoted to the management of gastrointestinal complications in patients with CKD. Methods The CKD Bowel Health Study is a multi-centre mixed-methods observational longitudinal study to better understand the bowel health and GI symptom management in patients with CKD. The program comprises of a longitudinal study that will assess the burden and risk factors of GI intolerance in patients treated with maintenance dialysis; a semi-structured interview study that will describe experiences of GI intolerance (including symptoms, treatment, self-management) in transplant candidates and recipients; and a discrete choice experience to elicit patient preferences regarding their experiences and perspectives of various intervention strategies for the management of GI symptoms after kidney transplantation. Discussion This proposed program of work aims to define the burden the GI intolerance in patients with kidney failure and generate evidence on the patients’ experiences of GI intolerance and their perspectives on their clinical and own management strategies of these symptoms, ensuring a patient-centred approach to guide clinical decision making and to inform the best study design for intervention trials. Trial registration This study is registered on the Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12621000548831 . This study has been approved by the Western Sydney Local Health District Human Research Ethics Committee of New South Wales Health (HREC ETH03007). This study is supported by a National Health and Medical Research Council (NHMRC) Australia Investigator Grant (APP1195414), and an NHMRC Australia Postgraduate Scholarship (APP2005244).Tess E. CooperAmy DaltonAnh KieuMartin HowellSumedh JayantiRabia KhalidWai H. LimNicole Scholes-RobertsonJonathan C. CraigArmando Teixeira-PintoMichael J. BourkeAllison TongGermaine WongBMCarticleChronic kidney diseaseKidney transplantDialysisGut microbiomeUremic toxinsGut microbiotaDiseases of the genitourinary system. UrologyRC870-923ENBMC Nephrology, Vol 22, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chronic kidney disease Kidney transplant Dialysis Gut microbiome Uremic toxins Gut microbiota Diseases of the genitourinary system. Urology RC870-923
spellingShingle	Chronic kidney disease Kidney transplant Dialysis Gut microbiome Uremic toxins Gut microbiota Diseases of the genitourinary system. Urology RC870-923 Tess E. Cooper Amy Dalton Anh Kieu Martin Howell Sumedh Jayanti Rabia Khalid Wai H. Lim Nicole Scholes-Robertson Jonathan C. Craig Armando Teixeira-Pinto Michael J. Bourke Allison Tong Germaine Wong The CKD bowel health study: understanding the bowel health and gastrointestinal symptom management in patients with chronic kidney disease: a mixed-methods observational longitudinal study (protocol)
description	Abstract Background Gastro-intestinal (GI) intolerance is a frequently reported outcome in patients with kidney failure receiving maintenance dialysis and those who have received kidney transplants. Symptoms of GI intolerance (diarrhoea, constipation, bloating, abdominal pain, heart burn, and reflux) are associated with significant reduction in quality of life, morbidity, and increased used of healthcare resources. Having chronic kidney disease (CKD), together with related changes in diet and medication, may alter the gut microbiota and the microbial-derived uraemic metabolites that accumulate in kidney failure, and contribute to various complications including chronic diarrhoea, opportunistic infections, and drug-related colitis. Despite the high disease burden among patients with kidney replacement therapies, GI symptoms are often under-recognised and, consequently limited resources and strategies are devoted to the management of gastrointestinal complications in patients with CKD. Methods The CKD Bowel Health Study is a multi-centre mixed-methods observational longitudinal study to better understand the bowel health and GI symptom management in patients with CKD. The program comprises of a longitudinal study that will assess the burden and risk factors of GI intolerance in patients treated with maintenance dialysis; a semi-structured interview study that will describe experiences of GI intolerance (including symptoms, treatment, self-management) in transplant candidates and recipients; and a discrete choice experience to elicit patient preferences regarding their experiences and perspectives of various intervention strategies for the management of GI symptoms after kidney transplantation. Discussion This proposed program of work aims to define the burden the GI intolerance in patients with kidney failure and generate evidence on the patients’ experiences of GI intolerance and their perspectives on their clinical and own management strategies of these symptoms, ensuring a patient-centred approach to guide clinical decision making and to inform the best study design for intervention trials. Trial registration This study is registered on the Australian New Zealand Clinical Trials Registry (ANZCTR): ACTRN12621000548831 . This study has been approved by the Western Sydney Local Health District Human Research Ethics Committee of New South Wales Health (HREC ETH03007). This study is supported by a National Health and Medical Research Council (NHMRC) Australia Investigator Grant (APP1195414), and an NHMRC Australia Postgraduate Scholarship (APP2005244).
format	article
author	Tess E. Cooper Amy Dalton Anh Kieu Martin Howell Sumedh Jayanti Rabia Khalid Wai H. Lim Nicole Scholes-Robertson Jonathan C. Craig Armando Teixeira-Pinto Michael J. Bourke Allison Tong Germaine Wong
author_facet	Tess E. Cooper Amy Dalton Anh Kieu Martin Howell Sumedh Jayanti Rabia Khalid Wai H. Lim Nicole Scholes-Robertson Jonathan C. Craig Armando Teixeira-Pinto Michael J. Bourke Allison Tong Germaine Wong
author_sort	Tess E. Cooper
title	The CKD bowel health study: understanding the bowel health and gastrointestinal symptom management in patients with chronic kidney disease: a mixed-methods observational longitudinal study (protocol)
title_short	The CKD bowel health study: understanding the bowel health and gastrointestinal symptom management in patients with chronic kidney disease: a mixed-methods observational longitudinal study (protocol)
title_full	The CKD bowel health study: understanding the bowel health and gastrointestinal symptom management in patients with chronic kidney disease: a mixed-methods observational longitudinal study (protocol)
title_fullStr	The CKD bowel health study: understanding the bowel health and gastrointestinal symptom management in patients with chronic kidney disease: a mixed-methods observational longitudinal study (protocol)
title_full_unstemmed	The CKD bowel health study: understanding the bowel health and gastrointestinal symptom management in patients with chronic kidney disease: a mixed-methods observational longitudinal study (protocol)
title_sort	ckd bowel health study: understanding the bowel health and gastrointestinal symptom management in patients with chronic kidney disease: a mixed-methods observational longitudinal study (protocol)
publisher	BMC
publishDate	2021
url	https://doaj.org/article/79d2def4429349b5bf22e3b95243a460
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The CKD bowel health study: understanding the bowel health and gastrointestinal symptom management in patients with chronic kidney disease: a mixed-methods observational longitudinal study (protocol)

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