Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10 attenuate D-galactosamine-induced liver injury by modifying the gut microbiota

Abstract The gut microbiota is altered in liver diseases, and several probiotics have been shown to reduce the degree of liver damage. We hypothesized that oral administration of specific Bifidobacterium strains isolated from healthy guts could attenuate liver injury. Five strains were tested in thi...

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Autores principales:	Daiqiong Fang, Ding Shi, Longxian Lv, Silan Gu, Wenrui Wu, Yanfei Chen, Jing Guo, Ang Li, Xinjun Hu, Feifei Guo, Jianzhong Ye, Yating Li, Lanjian Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/79d4d51649f24caaa85e5f93126976ec
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spelling	oai:doaj.org-article:79d4d51649f24caaa85e5f93126976ec2021-12-02T15:05:13ZBifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10 attenuate D-galactosamine-induced liver injury by modifying the gut microbiota10.1038/s41598-017-09395-82045-2322https://doaj.org/article/79d4d51649f24caaa85e5f93126976ec2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09395-8https://doaj.org/toc/2045-2322Abstract The gut microbiota is altered in liver diseases, and several probiotics have been shown to reduce the degree of liver damage. We hypothesized that oral administration of specific Bifidobacterium strains isolated from healthy guts could attenuate liver injury. Five strains were tested in this study. Acute liver injury was induced by D-galactosamine after pretreating Sprague-Dawley rats with the Bifidobacterium strains, and liver function, liver and ileum histology, plasma cytokines, bacterial translocation and the gut microbiome were assessed. Two strains, Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10, conferred liver protection, as well as alleviated the increase in plasma M-CSF, MIP-1α and MCP-1 and bacterial translocation. They also ameliorated ileal mucosal injury and gut flora dysbiosis, especially the enrichment of the opportunistic pathogen Parasutterella and the depletion of the SCFA-producing bacteria Anaerostipes, Coprococcus and Clostridium XI. Negative correlations were found between MIP-1α / MCP-1 and Odoribacter (LI09 group) and MIP-1α / M-CSF and Flavonifractor (LI10 group). Our results indicate that the liver protection effects might be mediated through gut microbiota modification, which thus affect the host immune profile. The desirable characteristics of these two strains may enable them to serve as potential probiotics for the prevention or adjuvant treatment of liver injury.Daiqiong FangDing ShiLongxian LvSilan GuWenrui WuYanfei ChenJing GuoAng LiXinjun HuFeifei GuoJianzhong YeYating LiLanjian LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Daiqiong Fang Ding Shi Longxian Lv Silan Gu Wenrui Wu Yanfei Chen Jing Guo Ang Li Xinjun Hu Feifei Guo Jianzhong Ye Yating Li Lanjian Li Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10 attenuate D-galactosamine-induced liver injury by modifying the gut microbiota
description	Abstract The gut microbiota is altered in liver diseases, and several probiotics have been shown to reduce the degree of liver damage. We hypothesized that oral administration of specific Bifidobacterium strains isolated from healthy guts could attenuate liver injury. Five strains were tested in this study. Acute liver injury was induced by D-galactosamine after pretreating Sprague-Dawley rats with the Bifidobacterium strains, and liver function, liver and ileum histology, plasma cytokines, bacterial translocation and the gut microbiome were assessed. Two strains, Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10, conferred liver protection, as well as alleviated the increase in plasma M-CSF, MIP-1α and MCP-1 and bacterial translocation. They also ameliorated ileal mucosal injury and gut flora dysbiosis, especially the enrichment of the opportunistic pathogen Parasutterella and the depletion of the SCFA-producing bacteria Anaerostipes, Coprococcus and Clostridium XI. Negative correlations were found between MIP-1α / MCP-1 and Odoribacter (LI09 group) and MIP-1α / M-CSF and Flavonifractor (LI10 group). Our results indicate that the liver protection effects might be mediated through gut microbiota modification, which thus affect the host immune profile. The desirable characteristics of these two strains may enable them to serve as potential probiotics for the prevention or adjuvant treatment of liver injury.
format	article
author	Daiqiong Fang Ding Shi Longxian Lv Silan Gu Wenrui Wu Yanfei Chen Jing Guo Ang Li Xinjun Hu Feifei Guo Jianzhong Ye Yating Li Lanjian Li
author_facet	Daiqiong Fang Ding Shi Longxian Lv Silan Gu Wenrui Wu Yanfei Chen Jing Guo Ang Li Xinjun Hu Feifei Guo Jianzhong Ye Yating Li Lanjian Li
author_sort	Daiqiong Fang
title	Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10 attenuate D-galactosamine-induced liver injury by modifying the gut microbiota
title_short	Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10 attenuate D-galactosamine-induced liver injury by modifying the gut microbiota
title_full	Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10 attenuate D-galactosamine-induced liver injury by modifying the gut microbiota
title_fullStr	Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10 attenuate D-galactosamine-induced liver injury by modifying the gut microbiota
title_full_unstemmed	Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10 attenuate D-galactosamine-induced liver injury by modifying the gut microbiota
title_sort	bifidobacterium pseudocatenulatum li09 and bifidobacterium catenulatum li10 attenuate d-galactosamine-induced liver injury by modifying the gut microbiota
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/79d4d51649f24caaa85e5f93126976ec
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Bifidobacterium pseudocatenulatum LI09 and Bifidobacterium catenulatum LI10 attenuate D-galactosamine-induced liver injury by modifying the gut microbiota

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