A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites

The unfolded protein response (UPR) is a stress response pathway implicated in numerous diseases and chemotherapy resistance. Here, the authors define the UPR regulon with a multi-omics strategy, uncovering changes to mitochondrial one-carbon metabolism and concomitant resistance to folate-based the...

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Autores principales: Stefan Reich, Chi D. L. Nguyen, Canan Has, Sascha Steltgens, Himanshu Soni, Cristina Coman, Moritz Freyberg, Anna Bichler, Nicole Seifert, Dominik Conrad, Christiane B. Knobbe-Thomsen, Björn Tews, Grischa Toedt, Robert Ahrends, Jan Medenbach
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Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/79d8f5e4871145f68820d3fe6d215985
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spelling oai:doaj.org-article:79d8f5e4871145f68820d3fe6d2159852021-12-02T14:58:24ZA multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites10.1038/s41467-020-16747-y2041-1723https://doaj.org/article/79d8f5e4871145f68820d3fe6d2159852020-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-16747-yhttps://doaj.org/toc/2041-1723The unfolded protein response (UPR) is a stress response pathway implicated in numerous diseases and chemotherapy resistance. Here, the authors define the UPR regulon with a multi-omics strategy, uncovering changes to mitochondrial one-carbon metabolism and concomitant resistance to folate-based therapeutics.Stefan ReichChi D. L. NguyenCanan HasSascha SteltgensHimanshu SoniCristina ComanMoritz FreybergAnna BichlerNicole SeifertDominik ConradChristiane B. Knobbe-ThomsenBjörn TewsGrischa ToedtRobert AhrendsJan MedenbachNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Stefan Reich
Chi D. L. Nguyen
Canan Has
Sascha Steltgens
Himanshu Soni
Cristina Coman
Moritz Freyberg
Anna Bichler
Nicole Seifert
Dominik Conrad
Christiane B. Knobbe-Thomsen
Björn Tews
Grischa Toedt
Robert Ahrends
Jan Medenbach
A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites
description The unfolded protein response (UPR) is a stress response pathway implicated in numerous diseases and chemotherapy resistance. Here, the authors define the UPR regulon with a multi-omics strategy, uncovering changes to mitochondrial one-carbon metabolism and concomitant resistance to folate-based therapeutics.
format article
author Stefan Reich
Chi D. L. Nguyen
Canan Has
Sascha Steltgens
Himanshu Soni
Cristina Coman
Moritz Freyberg
Anna Bichler
Nicole Seifert
Dominik Conrad
Christiane B. Knobbe-Thomsen
Björn Tews
Grischa Toedt
Robert Ahrends
Jan Medenbach
author_facet Stefan Reich
Chi D. L. Nguyen
Canan Has
Sascha Steltgens
Himanshu Soni
Cristina Coman
Moritz Freyberg
Anna Bichler
Nicole Seifert
Dominik Conrad
Christiane B. Knobbe-Thomsen
Björn Tews
Grischa Toedt
Robert Ahrends
Jan Medenbach
author_sort Stefan Reich
title A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites
title_short A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites
title_full A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites
title_fullStr A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites
title_full_unstemmed A multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites
title_sort multi-omics analysis reveals the unfolded protein response regulon and stress-induced resistance to folate-based antimetabolites
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/79d8f5e4871145f68820d3fe6d215985
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