Allelic distribution of BDNF Val66Met polymorphism in healthy Romanian volunteers

Population stratification of functional gene polymorphisms is a potential confounding factor in genetic association studies. The Val66Met (rs6265) single-nucleotide polymorphism in the brain-derived neurotrophic factor gene (BDNF) exhibits one of the highest variabilities in terms of allelic distrib...

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Autores principales:	Vulturar Romana, Chiş Adina, Hambrich Melinda, Kelemen Beatrice, Ungureanu Loredana, Miu Andrei C.
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2016
Materias:	gene candidate gene polymorphism population stratification Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/79dd8337070143a2b567234a56aae0b2
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spelling	oai:doaj.org-article:79dd8337070143a2b567234a56aae0b22021-12-05T14:11:04ZAllelic distribution of BDNF Val66Met polymorphism in healthy Romanian volunteers2081-693610.1515/tnsci-2016-0006https://doaj.org/article/79dd8337070143a2b567234a56aae0b22016-01-01T00:00:00Zhttps://doi.org/10.1515/tnsci-2016-0006https://doaj.org/toc/2081-6936Population stratification of functional gene polymorphisms is a potential confounding factor in genetic association studies. The Val66Met (rs6265) single-nucleotide polymorphism in the brain-derived neurotrophic factor gene (BDNF) exhibits one of the highest variabilities in terms of allelic distribution between populations. The present study reports the distribution of BDNF Val66Met alleles in a sample of healthy volunteers (N = 1124) selected from the Romanian population. Frequencies were 80.74% for the Val allele and 19.26% for the Met allele. The data from this study extends efforts to map the allelic distribution of BDNF Val66Met in populations around the world and emphasizes that population stratification should be controlled for in future studies that report phenotypic associations in samples from different populations.Vulturar RomanaChiş AdinaHambrich MelindaKelemen BeatriceUngureanu LoredanaMiu Andrei C.De Gruyterarticlegene candidategene polymorphismpopulation stratificationNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENTranslational Neuroscience, Vol 7, Iss 1, Pp 31-34 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	gene candidate gene polymorphism population stratification Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	gene candidate gene polymorphism population stratification Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Vulturar Romana Chiş Adina Hambrich Melinda Kelemen Beatrice Ungureanu Loredana Miu Andrei C. Allelic distribution of BDNF Val66Met polymorphism in healthy Romanian volunteers
description	Population stratification of functional gene polymorphisms is a potential confounding factor in genetic association studies. The Val66Met (rs6265) single-nucleotide polymorphism in the brain-derived neurotrophic factor gene (BDNF) exhibits one of the highest variabilities in terms of allelic distribution between populations. The present study reports the distribution of BDNF Val66Met alleles in a sample of healthy volunteers (N = 1124) selected from the Romanian population. Frequencies were 80.74% for the Val allele and 19.26% for the Met allele. The data from this study extends efforts to map the allelic distribution of BDNF Val66Met in populations around the world and emphasizes that population stratification should be controlled for in future studies that report phenotypic associations in samples from different populations.
format	article
author	Vulturar Romana Chiş Adina Hambrich Melinda Kelemen Beatrice Ungureanu Loredana Miu Andrei C.
author_facet	Vulturar Romana Chiş Adina Hambrich Melinda Kelemen Beatrice Ungureanu Loredana Miu Andrei C.
author_sort	Vulturar Romana
title	Allelic distribution of BDNF Val66Met polymorphism in healthy Romanian volunteers
title_short	Allelic distribution of BDNF Val66Met polymorphism in healthy Romanian volunteers
title_full	Allelic distribution of BDNF Val66Met polymorphism in healthy Romanian volunteers
title_fullStr	Allelic distribution of BDNF Val66Met polymorphism in healthy Romanian volunteers
title_full_unstemmed	Allelic distribution of BDNF Val66Met polymorphism in healthy Romanian volunteers
title_sort	allelic distribution of bdnf val66met polymorphism in healthy romanian volunteers
publisher	De Gruyter
publishDate	2016
url	https://doaj.org/article/79dd8337070143a2b567234a56aae0b2
work_keys_str_mv	AT vulturarromana allelicdistributionofbdnfval66metpolymorphisminhealthyromanianvolunteers AT chisadina allelicdistributionofbdnfval66metpolymorphisminhealthyromanianvolunteers AT hambrichmelinda allelicdistributionofbdnfval66metpolymorphisminhealthyromanianvolunteers AT kelemenbeatrice allelicdistributionofbdnfval66metpolymorphisminhealthyromanianvolunteers AT ungureanuloredana allelicdistributionofbdnfval66metpolymorphisminhealthyromanianvolunteers AT miuandreic allelicdistributionofbdnfval66metpolymorphisminhealthyromanianvolunteers
_version_	1718371429516312576

Allelic distribution of BDNF Val66Met polymorphism in healthy Romanian volunteers

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