Influenza Viruses: Breaking All the Rules

ABSTRACT Influenza A viruses (IAV) are significant pathogens able to repeatedly switch hosts to infect multiple avian and mammalian species, including humans. The unpredictability of IAV evolution and interspecies movement creates continual public health challenges, such as the emergence of the 2009...

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Autores principales:	Jeffery K. Taubenberger, David M. Morens
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2013
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/79df5ab8430744069244592fe00b5783
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spelling	oai:doaj.org-article:79df5ab8430744069244592fe00b57832021-11-15T15:43:10ZInfluenza Viruses: Breaking All the Rules10.1128/mBio.00365-132150-7511https://doaj.org/article/79df5ab8430744069244592fe00b57832013-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00365-13https://doaj.org/toc/2150-7511ABSTRACT Influenza A viruses (IAV) are significant pathogens able to repeatedly switch hosts to infect multiple avian and mammalian species, including humans. The unpredictability of IAV evolution and interspecies movement creates continual public health challenges, such as the emergence of the 2009 pandemic H1N1 virus from swine, as well as pandemic threats from the ongoing H5N1 and the recent H7N9 epizootics. In the last decade there has been increased concern about the “dual use” nature of microbiology, and a set of guidelines covering “dual use research of concern” includes seven categories of potentially problematic scientific experiments. In this Perspective, we consider how in nature IAV continually undergo “dual use experiments” as a matter of evolution and selection, and we conclude that studying these properties of IAV is critical for mitigating and preventing future epidemics and pandemics.Jeffery K. TaubenbergerDavid M. MorensAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 4, Iss 4 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Jeffery K. Taubenberger David M. Morens Influenza Viruses: Breaking All the Rules
description	ABSTRACT Influenza A viruses (IAV) are significant pathogens able to repeatedly switch hosts to infect multiple avian and mammalian species, including humans. The unpredictability of IAV evolution and interspecies movement creates continual public health challenges, such as the emergence of the 2009 pandemic H1N1 virus from swine, as well as pandemic threats from the ongoing H5N1 and the recent H7N9 epizootics. In the last decade there has been increased concern about the “dual use” nature of microbiology, and a set of guidelines covering “dual use research of concern” includes seven categories of potentially problematic scientific experiments. In this Perspective, we consider how in nature IAV continually undergo “dual use experiments” as a matter of evolution and selection, and we conclude that studying these properties of IAV is critical for mitigating and preventing future epidemics and pandemics.
format	article
author	Jeffery K. Taubenberger David M. Morens
author_facet	Jeffery K. Taubenberger David M. Morens
author_sort	Jeffery K. Taubenberger
title	Influenza Viruses: Breaking All the Rules
title_short	Influenza Viruses: Breaking All the Rules
title_full	Influenza Viruses: Breaking All the Rules
title_fullStr	Influenza Viruses: Breaking All the Rules
title_full_unstemmed	Influenza Viruses: Breaking All the Rules
title_sort	influenza viruses: breaking all the rules
publisher	American Society for Microbiology
publishDate	2013
url	https://doaj.org/article/79df5ab8430744069244592fe00b5783
work_keys_str_mv	AT jefferyktaubenberger influenzavirusesbreakingalltherules AT davidmmorens influenzavirusesbreakingalltherules
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Influenza Viruses: Breaking All the Rules

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