Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation

Lysosomes are intracellular organelles containing degradative enzymes, and leakage of lysosomal contents into the cell is thought to trigger cell death. Here, the authors report that leaky lysosomes may facilitate chromosome separation during cell division.

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Autores principales:	Saara Hämälistö, Jonathan Lucien Stahl, Elena Favaro, Qing Yang, Bin Liu, Line Christoffersen, Ben Loos, Claudia Guasch Boldú, Johanna A. Joyce, Thomas Reinheckel, Marin Barisic, Marja Jäättelä
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/79e29c43ae8e4889bba0b9d7d4022b96
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spelling	oai:doaj.org-article:79e29c43ae8e4889bba0b9d7d4022b962021-12-02T17:32:11ZSpatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation10.1038/s41467-019-14009-02041-1723https://doaj.org/article/79e29c43ae8e4889bba0b9d7d4022b962020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14009-0https://doaj.org/toc/2041-1723Lysosomes are intracellular organelles containing degradative enzymes, and leakage of lysosomal contents into the cell is thought to trigger cell death. Here, the authors report that leaky lysosomes may facilitate chromosome separation during cell division.Saara HämälistöJonathan Lucien StahlElena FavaroQing YangBin LiuLine ChristoffersenBen LoosClaudia Guasch BoldúJohanna A. JoyceThomas ReinheckelMarin BarisicMarja JäätteläNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Saara Hämälistö Jonathan Lucien Stahl Elena Favaro Qing Yang Bin Liu Line Christoffersen Ben Loos Claudia Guasch Boldú Johanna A. Joyce Thomas Reinheckel Marin Barisic Marja Jäättelä Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
description	Lysosomes are intracellular organelles containing degradative enzymes, and leakage of lysosomal contents into the cell is thought to trigger cell death. Here, the authors report that leaky lysosomes may facilitate chromosome separation during cell division.
format	article
author	Saara Hämälistö Jonathan Lucien Stahl Elena Favaro Qing Yang Bin Liu Line Christoffersen Ben Loos Claudia Guasch Boldú Johanna A. Joyce Thomas Reinheckel Marin Barisic Marja Jäättelä
author_facet	Saara Hämälistö Jonathan Lucien Stahl Elena Favaro Qing Yang Bin Liu Line Christoffersen Ben Loos Claudia Guasch Boldú Johanna A. Joyce Thomas Reinheckel Marin Barisic Marja Jäättelä
author_sort	Saara Hämälistö
title	Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
title_short	Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
title_full	Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
title_fullStr	Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
title_full_unstemmed	Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
title_sort	spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/79e29c43ae8e4889bba0b9d7d4022b96
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Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation

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