Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity

The type II nuclear receptors (NRs) and the retinoid X receptor (RXR) form heterodimeric transcription factors to regulate development, metabolism, and inflammation. Here the authors employ protein-binding microarrays to comprehensively analyze the DNA binding of 12 NR:RXRα heterodimers, and report...

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Main Authors:	Ashley Penvose, Jessica L. Keenan, David Bray, Vijendra Ramlall, Trevor Siggers
Format:	article
Language:	EN
Published:	Nature Portfolio 2019
Subjects:	Science Q
Online Access:	https://doaj.org/article/79e323cec1f2436e87f4111b7b42c180
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id	oai:doaj.org-article:79e323cec1f2436e87f4111b7b42c180
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spelling	oai:doaj.org-article:79e323cec1f2436e87f4111b7b42c1802021-12-02T15:35:15ZComprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity10.1038/s41467-019-10264-32041-1723https://doaj.org/article/79e323cec1f2436e87f4111b7b42c1802019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10264-3https://doaj.org/toc/2041-1723The type II nuclear receptors (NRs) and the retinoid X receptor (RXR) form heterodimeric transcription factors to regulate development, metabolism, and inflammation. Here the authors employ protein-binding microarrays to comprehensively analyze the DNA binding of 12 NR:RXRα heterodimers, and report promiscuous NR-DNA binding.Ashley PenvoseJessica L. KeenanDavid BrayVijendra RamlallTrevor SiggersNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ashley Penvose Jessica L. Keenan David Bray Vijendra Ramlall Trevor Siggers Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity
description	The type II nuclear receptors (NRs) and the retinoid X receptor (RXR) form heterodimeric transcription factors to regulate development, metabolism, and inflammation. Here the authors employ protein-binding microarrays to comprehensively analyze the DNA binding of 12 NR:RXRα heterodimers, and report promiscuous NR-DNA binding.
format	article
author	Ashley Penvose Jessica L. Keenan David Bray Vijendra Ramlall Trevor Siggers
author_facet	Ashley Penvose Jessica L. Keenan David Bray Vijendra Ramlall Trevor Siggers
author_sort	Ashley Penvose
title	Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity
title_short	Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity
title_full	Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity
title_fullStr	Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity
title_full_unstemmed	Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity
title_sort	comprehensive study of nuclear receptor dna binding provides a revised framework for understanding receptor specificity
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/79e323cec1f2436e87f4111b7b42c180
work_keys_str_mv	AT ashleypenvose comprehensivestudyofnuclearreceptordnabindingprovidesarevisedframeworkforunderstandingreceptorspecificity AT jessicalkeenan comprehensivestudyofnuclearreceptordnabindingprovidesarevisedframeworkforunderstandingreceptorspecificity AT davidbray comprehensivestudyofnuclearreceptordnabindingprovidesarevisedframeworkforunderstandingreceptorspecificity AT vijendraramlall comprehensivestudyofnuclearreceptordnabindingprovidesarevisedframeworkforunderstandingreceptorspecificity AT trevorsiggers comprehensivestudyofnuclearreceptordnabindingprovidesarevisedframeworkforunderstandingreceptorspecificity
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Comprehensive study of nuclear receptor DNA binding provides a revised framework for understanding receptor specificity

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