Emerging role of free triiodothyronine in patients with anti-N-methyl-D-aspartate receptor encephalitis

Abstract We aimed to investigate the role of free triiodothyronine (FT3) in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. 137 consecutive inpatients (2016–2019) were registered prospectively and followed up for 12 months. 96 eligible patients were included in the study....

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Autores principales:	Tuo Ji, Zhi Huang, Yajun Lian, Chengze Wang, Qiaoman Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/79e993c8aa674b5aaebd69bae4e29f3e
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spelling	oai:doaj.org-article:79e993c8aa674b5aaebd69bae4e29f3e2021-12-02T13:17:49ZEmerging role of free triiodothyronine in patients with anti-N-methyl-D-aspartate receptor encephalitis10.1038/s41598-021-85596-62045-2322https://doaj.org/article/79e993c8aa674b5aaebd69bae4e29f3e2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-85596-6https://doaj.org/toc/2045-2322Abstract We aimed to investigate the role of free triiodothyronine (FT3) in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. 137 consecutive inpatients (2016–2019) were registered prospectively and followed up for 12 months. 96 eligible patients were included in the study. The modified Rankin scale (mRS) score was collected, and the score of 3–6 was defined as a poor outcome. The patients were equally classified into 3 subgroups based on their FT3 levels obtained within 24 h of admission, and the subgroup differences were analyzed by parametric or nonparametric tests as appropriate. Logistic regression analysis was performed. We found that there was no difference in the mRS scores upon admission among 3 subgroups, however, patients in the low-FT3 subgroup tended to have higher disease severity during hospitalization and worse outcome in follow-up visits, represented by higher chances of intense care unit (ICU) admission (P < 0.001), longer hospital stay (P < 0.001), greater maximum mRS scores during hospitalization (P = 0.011), lower rates of getting clinical improvement within 4 weeks of starting treatment (P = 0.006), and higher percentages of poor 1-year outcome (P = 0.002). The level of FT3 was an independent factor correlated with ICU admission (P = 0.002) and might be a potential predictor for 1-year outcome. Our preliminary results suggest that the FT3 may be a risk factor involved in the evolution and progression of anti-NMDAR encephalitis, whereas the underline mechanisms remain to be explored. Attention should be paid to these patients with relatively low FT3 upon admission, which might possibly aid clinical prediction and guide clinical decision-making.Tuo JiZhi HuangYajun LianChengze WangQiaoman ZhangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Tuo Ji Zhi Huang Yajun Lian Chengze Wang Qiaoman Zhang Emerging role of free triiodothyronine in patients with anti-N-methyl-D-aspartate receptor encephalitis
description	Abstract We aimed to investigate the role of free triiodothyronine (FT3) in patients with anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis. 137 consecutive inpatients (2016–2019) were registered prospectively and followed up for 12 months. 96 eligible patients were included in the study. The modified Rankin scale (mRS) score was collected, and the score of 3–6 was defined as a poor outcome. The patients were equally classified into 3 subgroups based on their FT3 levels obtained within 24 h of admission, and the subgroup differences were analyzed by parametric or nonparametric tests as appropriate. Logistic regression analysis was performed. We found that there was no difference in the mRS scores upon admission among 3 subgroups, however, patients in the low-FT3 subgroup tended to have higher disease severity during hospitalization and worse outcome in follow-up visits, represented by higher chances of intense care unit (ICU) admission (P < 0.001), longer hospital stay (P < 0.001), greater maximum mRS scores during hospitalization (P = 0.011), lower rates of getting clinical improvement within 4 weeks of starting treatment (P = 0.006), and higher percentages of poor 1-year outcome (P = 0.002). The level of FT3 was an independent factor correlated with ICU admission (P = 0.002) and might be a potential predictor for 1-year outcome. Our preliminary results suggest that the FT3 may be a risk factor involved in the evolution and progression of anti-NMDAR encephalitis, whereas the underline mechanisms remain to be explored. Attention should be paid to these patients with relatively low FT3 upon admission, which might possibly aid clinical prediction and guide clinical decision-making.
format	article
author	Tuo Ji Zhi Huang Yajun Lian Chengze Wang Qiaoman Zhang
author_facet	Tuo Ji Zhi Huang Yajun Lian Chengze Wang Qiaoman Zhang
author_sort	Tuo Ji
title	Emerging role of free triiodothyronine in patients with anti-N-methyl-D-aspartate receptor encephalitis
title_short	Emerging role of free triiodothyronine in patients with anti-N-methyl-D-aspartate receptor encephalitis
title_full	Emerging role of free triiodothyronine in patients with anti-N-methyl-D-aspartate receptor encephalitis
title_fullStr	Emerging role of free triiodothyronine in patients with anti-N-methyl-D-aspartate receptor encephalitis
title_full_unstemmed	Emerging role of free triiodothyronine in patients with anti-N-methyl-D-aspartate receptor encephalitis
title_sort	emerging role of free triiodothyronine in patients with anti-n-methyl-d-aspartate receptor encephalitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/79e993c8aa674b5aaebd69bae4e29f3e
work_keys_str_mv	AT tuoji emergingroleoffreetriiodothyronineinpatientswithantinmethyldaspartatereceptorencephalitis AT zhihuang emergingroleoffreetriiodothyronineinpatientswithantinmethyldaspartatereceptorencephalitis AT yajunlian emergingroleoffreetriiodothyronineinpatientswithantinmethyldaspartatereceptorencephalitis AT chengzewang emergingroleoffreetriiodothyronineinpatientswithantinmethyldaspartatereceptorencephalitis AT qiaomanzhang emergingroleoffreetriiodothyronineinpatientswithantinmethyldaspartatereceptorencephalitis
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Emerging role of free triiodothyronine in patients with anti-N-methyl-D-aspartate receptor encephalitis

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