FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human

The inhibitory receptor, FcγRIIb, is reported to limit autoimmune B cell response. Here the authors show that FcγRIIb has a dual role in both human and mouse, with reduced FcγRIIb expression or function associated with enhanced pre-immune B cell tolerance, yet defective control of mature autoreactiv...

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Autores principales:	Marion Espéli, Rachael Bashford-Rogers, John M. Sowerby, Nagham Alouche, Limy Wong, Alice E. Denton, Michelle A. Linterman, Kenneth G. C. Smith
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/79eaab1ad06c4833bed4609c3c0f95a6
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spelling	oai:doaj.org-article:79eaab1ad06c4833bed4609c3c0f95a62021-12-02T17:01:47ZFcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human10.1038/s41467-019-09434-02041-1723https://doaj.org/article/79eaab1ad06c4833bed4609c3c0f95a62019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09434-0https://doaj.org/toc/2041-1723The inhibitory receptor, FcγRIIb, is reported to limit autoimmune B cell response. Here the authors show that FcγRIIb has a dual role in both human and mouse, with reduced FcγRIIb expression or function associated with enhanced pre-immune B cell tolerance, yet defective control of mature autoreactive B cells in the germinal center.Marion EspéliRachael Bashford-RogersJohn M. SowerbyNagham AloucheLimy WongAlice E. DentonMichelle A. LintermanKenneth G. C. SmithNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marion Espéli Rachael Bashford-Rogers John M. Sowerby Nagham Alouche Limy Wong Alice E. Denton Michelle A. Linterman Kenneth G. C. Smith FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human
description	The inhibitory receptor, FcγRIIb, is reported to limit autoimmune B cell response. Here the authors show that FcγRIIb has a dual role in both human and mouse, with reduced FcγRIIb expression or function associated with enhanced pre-immune B cell tolerance, yet defective control of mature autoreactive B cells in the germinal center.
format	article
author	Marion Espéli Rachael Bashford-Rogers John M. Sowerby Nagham Alouche Limy Wong Alice E. Denton Michelle A. Linterman Kenneth G. C. Smith
author_facet	Marion Espéli Rachael Bashford-Rogers John M. Sowerby Nagham Alouche Limy Wong Alice E. Denton Michelle A. Linterman Kenneth G. C. Smith
author_sort	Marion Espéli
title	FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human
title_short	FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human
title_full	FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human
title_fullStr	FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human
title_full_unstemmed	FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human
title_sort	fcγriib differentially regulates pre-immune and germinal center b cell tolerance in mouse and human
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/79eaab1ad06c4833bed4609c3c0f95a6
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FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human

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