The Correlation Between Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio with Hepatic Echinococcosis

Weijian E,1 Zhixin Wang,2 Mingquan Pang,2,3 Yongliang Lu,1 Haining Fan2,3 1Centre of Medical Laboratory Technology & Laboratory Diagnostics, Affiliated Hospital of Qinghai University, Xining, Qinghai, 810001, People’s Republic of China; 2Department of Hepatopancreatobiliary Surgery...

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Autores principales:	E Weijian, Wang Z, Pang MQ, Lu Y, Fan H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	platelet-tolymphocyte ratio (plr);neutrophil-tolymphocyte ratio (nlr) alveolar echinococcosis cystic echinococcosis inflammation Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/79eb00b18b2e480c9257785f870476a0
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spelling	oai:doaj.org-article:79eb00b18b2e480c9257785f870476a02021-12-02T15:46:38ZThe Correlation Between Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio with Hepatic Echinococcosis1178-7031https://doaj.org/article/79eb00b18b2e480c9257785f870476a02021-06-01T00:00:00Zhttps://www.dovepress.com/the-correlation-between-platelet-to-lymphocyte-ratio-and-neutrophil-to-peer-reviewed-fulltext-article-JIRhttps://doaj.org/toc/1178-7031Weijian E,1 Zhixin Wang,2 Mingquan Pang,2,3 Yongliang Lu,1 Haining Fan2,3 1Centre of Medical Laboratory Technology & Laboratory Diagnostics, Affiliated Hospital of Qinghai University, Xining, Qinghai, 810001, People’s Republic of China; 2Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, Xining, Qinghai, 810001, People’s Republic of China; 3Qinghai Provincial Research Key Laboratory for Hydatid, Xining, Qinghai, 810001, People’s Republic of ChinaCorrespondence: Weijian ECentre of Medical Laboratory Technology & Laboratory Diagnostics, Affiliated Hospital of Qinghai University, 29 Tongren Road, Xining, Qinghai, 810001, People’s Republic of ChinaTel/Fax +86 971-6230672Email e_weijian220@163.comHaining FanQinghai Provincial Research Key Laboratory for Hydatid, 29 Tongren Road, Xining, Qinghai, 810001, People’s Republic of ChinaTel/Fax +86 971-6162000Email fanhaining_ve@21cn.comObjective: To explore the correlation between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with hepatic hydatid diseases.Methods: The clinical data of 420 patients with hydatid disease who were treated in our hospital from October 2015 to October 2018 were collected from the database of our hospital. According to the postoperative pathological diagnosis, 200 patients were assigned into the alveolar echinococcosis (AE) group, and 220 patients were assigned into the cystic echinococcosis (CE) group. A total of 160 healthy examinees were enrolled as the control group. The main observation indexes included preoperative PLR and NLR. Pearson’s correlation was used to analyze the correlation between PLR and NLR with clinical indicators in HE patients, and the receiver operator characteristic (ROC) curve was used to evaluate the clinical values of PLR and NLR in diagnosing different types of hydatid diseases.Results: The results revealed that the expressions of PLR and NLR were significantly higher in the AE group than in the CE and control groups (P< 0.05). The results of multiple linear regression analysis revealed that PLR was positively correlated with aspartate aminotransferase, alanine aminotransferase, total bilirubin, direct bilirubin, alkaline phosphatase and γ-glutamyltranspeptidase (P< 0.05). NLR was correlated with albumin content (P< 0.05). ROC curve analysis results revealed that the area under the curve (AUC) of PLR and NLR for AE was 0.800 and 0.700 respectively, and the AUC for CE was 0.78 and 0.75 respectively.Conclusion: The NLR and PLR of AE patients were higher than those of CE patients, and the high inflammation of CE patients may be correlated to the reproductive mode of Echinococcus multilocularis. PLR and NLR have certain diagnostic values for disease classification, but PLR has higher specificity when compared with NLR.Keywords: platelet-to-lymphocyte ratio, PLR, neutrophil-to-lymphocyte ratio, NLR, alveolar echinococcosis, cystic echinococcosis, inflammationE WeijianWang ZPang MQLu YFan HDove Medical Pressarticleplatelet-tolymphocyte ratio (plr);neutrophil-tolymphocyte ratio (nlr)alveolar echinococcosiscystic echinococcosisinflammationPathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 2403-2409 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	platelet-tolymphocyte ratio (plr);neutrophil-tolymphocyte ratio (nlr) alveolar echinococcosis cystic echinococcosis inflammation Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	platelet-tolymphocyte ratio (plr);neutrophil-tolymphocyte ratio (nlr) alveolar echinococcosis cystic echinococcosis inflammation Pathology RB1-214 Therapeutics. Pharmacology RM1-950 E Weijian Wang Z Pang MQ Lu Y Fan H The Correlation Between Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio with Hepatic Echinococcosis
description	Weijian E,1 Zhixin Wang,2 Mingquan Pang,2,3 Yongliang Lu,1 Haining Fan2,3 1Centre of Medical Laboratory Technology & Laboratory Diagnostics, Affiliated Hospital of Qinghai University, Xining, Qinghai, 810001, People’s Republic of China; 2Department of Hepatopancreatobiliary Surgery, Affiliated Hospital of Qinghai University, Xining, Qinghai, 810001, People’s Republic of China; 3Qinghai Provincial Research Key Laboratory for Hydatid, Xining, Qinghai, 810001, People’s Republic of ChinaCorrespondence: Weijian ECentre of Medical Laboratory Technology & Laboratory Diagnostics, Affiliated Hospital of Qinghai University, 29 Tongren Road, Xining, Qinghai, 810001, People’s Republic of ChinaTel/Fax +86 971-6230672Email e_weijian220@163.comHaining FanQinghai Provincial Research Key Laboratory for Hydatid, 29 Tongren Road, Xining, Qinghai, 810001, People’s Republic of ChinaTel/Fax +86 971-6162000Email fanhaining_ve@21cn.comObjective: To explore the correlation between neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with hepatic hydatid diseases.Methods: The clinical data of 420 patients with hydatid disease who were treated in our hospital from October 2015 to October 2018 were collected from the database of our hospital. According to the postoperative pathological diagnosis, 200 patients were assigned into the alveolar echinococcosis (AE) group, and 220 patients were assigned into the cystic echinococcosis (CE) group. A total of 160 healthy examinees were enrolled as the control group. The main observation indexes included preoperative PLR and NLR. Pearson’s correlation was used to analyze the correlation between PLR and NLR with clinical indicators in HE patients, and the receiver operator characteristic (ROC) curve was used to evaluate the clinical values of PLR and NLR in diagnosing different types of hydatid diseases.Results: The results revealed that the expressions of PLR and NLR were significantly higher in the AE group than in the CE and control groups (P< 0.05). The results of multiple linear regression analysis revealed that PLR was positively correlated with aspartate aminotransferase, alanine aminotransferase, total bilirubin, direct bilirubin, alkaline phosphatase and γ-glutamyltranspeptidase (P< 0.05). NLR was correlated with albumin content (P< 0.05). ROC curve analysis results revealed that the area under the curve (AUC) of PLR and NLR for AE was 0.800 and 0.700 respectively, and the AUC for CE was 0.78 and 0.75 respectively.Conclusion: The NLR and PLR of AE patients were higher than those of CE patients, and the high inflammation of CE patients may be correlated to the reproductive mode of Echinococcus multilocularis. PLR and NLR have certain diagnostic values for disease classification, but PLR has higher specificity when compared with NLR.Keywords: platelet-to-lymphocyte ratio, PLR, neutrophil-to-lymphocyte ratio, NLR, alveolar echinococcosis, cystic echinococcosis, inflammation
format	article
author	E Weijian Wang Z Pang MQ Lu Y Fan H
author_facet	E Weijian Wang Z Pang MQ Lu Y Fan H
author_sort	E Weijian
title	The Correlation Between Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio with Hepatic Echinococcosis
title_short	The Correlation Between Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio with Hepatic Echinococcosis
title_full	The Correlation Between Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio with Hepatic Echinococcosis
title_fullStr	The Correlation Between Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio with Hepatic Echinococcosis
title_full_unstemmed	The Correlation Between Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio with Hepatic Echinococcosis
title_sort	correlation between platelet-to-lymphocyte ratio and neutrophil-to-lymphocyte ratio with hepatic echinococcosis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/79eb00b18b2e480c9257785f870476a0
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The Correlation Between Platelet-to-Lymphocyte Ratio and Neutrophil-to-Lymphocyte Ratio with Hepatic Echinococcosis

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