Secretagogin expression in the mouse olfactory bulb under sensory impairments

Abstract The interneurons of the olfactory bulb (OB) are characterized by the expression of different calcium-binding proteins, whose specific functions are not fully understood. This is the case of one of the most recently discovered, the secretagogin (SCGN), which is expressed in interneurons of t...

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Autores principales:	L. Pérez-Revuelta, P. G. Téllez de Meneses, M. López, J. G. Briñón, E. Weruaga, D. Díaz, J. R. Alonso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/79ee10b1724444bc91741854de8a066d
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spelling	oai:doaj.org-article:79ee10b1724444bc91741854de8a066d2021-12-02T11:43:58ZSecretagogin expression in the mouse olfactory bulb under sensory impairments10.1038/s41598-020-78499-52045-2322https://doaj.org/article/79ee10b1724444bc91741854de8a066d2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78499-5https://doaj.org/toc/2045-2322Abstract The interneurons of the olfactory bulb (OB) are characterized by the expression of different calcium-binding proteins, whose specific functions are not fully understood. This is the case of one of the most recently discovered, the secretagogin (SCGN), which is expressed in interneurons of the glomerular and the granule cell layers, but whose function in the olfactory pathway is still unknown. To address this question, we examined the distribution, generation and activity of SCGN-positive interneurons in the OB of two complementary models of olfactory impairments: Purkinje Cell Degeneration (PCD) and olfactory-deprived mice. Our results showed a significant increase in the density of SCGN-positive cells in the inframitral layers of olfactory-deprived mice as compared to control animals. Moreover, BrdU analyses revealed that these additional SCGN-positive cells are not newly formed. Finally, the neuronal activity, estimated by c-Fos expression, increased in preexisting SCGN-positive interneurons of both deprived and PCD mice -being higher in the later- in comparison with control animals. Altogether, our results suggest that the OB possesses different compensatory mechanisms depending on the type of alteration. Particularly, the SCGN expression is dependent of olfactory stimuli and its function may be related to a compensation against a reduction in sensory inputs.L. Pérez-RevueltaP. G. Téllez de MenesesM. LópezJ. G. BriñónE. WeruagaD. DíazJ. R. AlonsoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q L. Pérez-Revuelta P. G. Téllez de Meneses M. López J. G. Briñón E. Weruaga D. Díaz J. R. Alonso Secretagogin expression in the mouse olfactory bulb under sensory impairments
description	Abstract The interneurons of the olfactory bulb (OB) are characterized by the expression of different calcium-binding proteins, whose specific functions are not fully understood. This is the case of one of the most recently discovered, the secretagogin (SCGN), which is expressed in interneurons of the glomerular and the granule cell layers, but whose function in the olfactory pathway is still unknown. To address this question, we examined the distribution, generation and activity of SCGN-positive interneurons in the OB of two complementary models of olfactory impairments: Purkinje Cell Degeneration (PCD) and olfactory-deprived mice. Our results showed a significant increase in the density of SCGN-positive cells in the inframitral layers of olfactory-deprived mice as compared to control animals. Moreover, BrdU analyses revealed that these additional SCGN-positive cells are not newly formed. Finally, the neuronal activity, estimated by c-Fos expression, increased in preexisting SCGN-positive interneurons of both deprived and PCD mice -being higher in the later- in comparison with control animals. Altogether, our results suggest that the OB possesses different compensatory mechanisms depending on the type of alteration. Particularly, the SCGN expression is dependent of olfactory stimuli and its function may be related to a compensation against a reduction in sensory inputs.
format	article
author	L. Pérez-Revuelta P. G. Téllez de Meneses M. López J. G. Briñón E. Weruaga D. Díaz J. R. Alonso
author_facet	L. Pérez-Revuelta P. G. Téllez de Meneses M. López J. G. Briñón E. Weruaga D. Díaz J. R. Alonso
author_sort	L. Pérez-Revuelta
title	Secretagogin expression in the mouse olfactory bulb under sensory impairments
title_short	Secretagogin expression in the mouse olfactory bulb under sensory impairments
title_full	Secretagogin expression in the mouse olfactory bulb under sensory impairments
title_fullStr	Secretagogin expression in the mouse olfactory bulb under sensory impairments
title_full_unstemmed	Secretagogin expression in the mouse olfactory bulb under sensory impairments
title_sort	secretagogin expression in the mouse olfactory bulb under sensory impairments
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/79ee10b1724444bc91741854de8a066d
work_keys_str_mv	AT lperezrevuelta secretagoginexpressioninthemouseolfactorybulbundersensoryimpairments AT pgtellezdemeneses secretagoginexpressioninthemouseolfactorybulbundersensoryimpairments AT mlopez secretagoginexpressioninthemouseolfactorybulbundersensoryimpairments AT jgbrinon secretagoginexpressioninthemouseolfactorybulbundersensoryimpairments AT eweruaga secretagoginexpressioninthemouseolfactorybulbundersensoryimpairments AT ddiaz secretagoginexpressioninthemouseolfactorybulbundersensoryimpairments AT jralonso secretagoginexpressioninthemouseolfactorybulbundersensoryimpairments
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Secretagogin expression in the mouse olfactory bulb under sensory impairments

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