Association of TNF-alpha G-308A gene polymorphism with depression: a meta-analysis

Kwang-Hee Shin,1 Hyeon Cheol Jeong,1 Dong-Hee Choi,2 Sung Nyun Kim,3 Tae-Eun Kim4 1College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 2Department of Medical Science, Konkuk University School of Medicine, 3Department of Psychiatry, Seoul Medical...

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Autores principales:	Shin KH, Jeong HC, Choi DH, Kim SN, Kim TE
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	TNF-α G-308A rs1800629 genetic polymorphism depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/79efdfbc9e3d4c4bad1acc28f81b3753
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spelling	oai:doaj.org-article:79efdfbc9e3d4c4bad1acc28f81b37532021-12-02T03:49:48ZAssociation of TNF-alpha G-308A gene polymorphism with depression: a meta-analysis1178-2021https://doaj.org/article/79efdfbc9e3d4c4bad1acc28f81b37532017-10-01T00:00:00Zhttps://www.dovepress.com/association-of-tnf-alpha-g-308a-gene-polymorphism-with-depression-a-me-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Kwang-Hee Shin,1 Hyeon Cheol Jeong,1 Dong-Hee Choi,2 Sung Nyun Kim,3 Tae-Eun Kim4 1College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 2Department of Medical Science, Konkuk University School of Medicine, 3Department of Psychiatry, Seoul Medical Center, 4Department of Clinical Pharmacology, Konkuk University Medical Center, Seoul, Republic of Korea Background: Although many studies have investigated the association of a single nucleotide polymorphism in TNF-α G-308A gene with depression, their association is still controversial. To clarify this, we performed a meta-analysis.Method: Studies related to TNF-α G-308A and depression were retrieved from PubMed, Medline, Embase, and Scopus (up to April 18, 2017). The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated in the models of allele comparison (G vs A), homozygote comparison (GG vs AA), dominant (GG vs GA + AA), and recessive (GG + GA vs AA) to estimate the strength of the associations.Results: A total of 10 case–control studies were included in this meta-analysis. Overall, no significant association between TNF-α G-308A and depression was found (G vs A: OR [95% CI] =1.09 [0.92, 1.29]; GG vs AA: 1.24 [0.71, 2.15]; GG vs GA + AA: 1.01 [0.76, 1.35]; GG + GA vs AA: 1.22 [0.70, 2.13]). In subgroup analyses by ethnicity or age group, no statistically significant association between TNF-α G-308A polymorphisms and depression was shown.Conclusion: This meta-analysis revealed that TNF-α G-308A polymorphism is not associated with susceptibility to depression. Keywords: TNF-α G-308A, rs1800629, genetic polymorphism, depressive disorderShin KHJeong HCChoi DHKim SNKim TEDove Medical PressarticleTNF-α G-308Ars1800629genetic polymorphismdepressionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 13, Pp 2661-2668 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	TNF-α G-308A rs1800629 genetic polymorphism depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	TNF-α G-308A rs1800629 genetic polymorphism depression Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Shin KH Jeong HC Choi DH Kim SN Kim TE Association of TNF-alpha G-308A gene polymorphism with depression: a meta-analysis
description	Kwang-Hee Shin,1 Hyeon Cheol Jeong,1 Dong-Hee Choi,2 Sung Nyun Kim,3 Tae-Eun Kim4 1College of Pharmacy, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, 2Department of Medical Science, Konkuk University School of Medicine, 3Department of Psychiatry, Seoul Medical Center, 4Department of Clinical Pharmacology, Konkuk University Medical Center, Seoul, Republic of Korea Background: Although many studies have investigated the association of a single nucleotide polymorphism in TNF-α G-308A gene with depression, their association is still controversial. To clarify this, we performed a meta-analysis.Method: Studies related to TNF-α G-308A and depression were retrieved from PubMed, Medline, Embase, and Scopus (up to April 18, 2017). The odds ratios (ORs) and 95% confidence intervals (CIs) were estimated in the models of allele comparison (G vs A), homozygote comparison (GG vs AA), dominant (GG vs GA + AA), and recessive (GG + GA vs AA) to estimate the strength of the associations.Results: A total of 10 case–control studies were included in this meta-analysis. Overall, no significant association between TNF-α G-308A and depression was found (G vs A: OR [95% CI] =1.09 [0.92, 1.29]; GG vs AA: 1.24 [0.71, 2.15]; GG vs GA + AA: 1.01 [0.76, 1.35]; GG + GA vs AA: 1.22 [0.70, 2.13]). In subgroup analyses by ethnicity or age group, no statistically significant association between TNF-α G-308A polymorphisms and depression was shown.Conclusion: This meta-analysis revealed that TNF-α G-308A polymorphism is not associated with susceptibility to depression. Keywords: TNF-α G-308A, rs1800629, genetic polymorphism, depressive disorder
format	article
author	Shin KH Jeong HC Choi DH Kim SN Kim TE
author_facet	Shin KH Jeong HC Choi DH Kim SN Kim TE
author_sort	Shin KH
title	Association of TNF-alpha G-308A gene polymorphism with depression: a meta-analysis
title_short	Association of TNF-alpha G-308A gene polymorphism with depression: a meta-analysis
title_full	Association of TNF-alpha G-308A gene polymorphism with depression: a meta-analysis
title_fullStr	Association of TNF-alpha G-308A gene polymorphism with depression: a meta-analysis
title_full_unstemmed	Association of TNF-alpha G-308A gene polymorphism with depression: a meta-analysis
title_sort	association of tnf-alpha g-308a gene polymorphism with depression: a meta-analysis
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/79efdfbc9e3d4c4bad1acc28f81b3753
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Association of TNF-alpha G-308A gene polymorphism with depression: a meta-analysis

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