Weakening of resistance force by cell–ECM interactions regulate cell migration directionality and pattern formation

Hagiwara et al. investigate how spatio-temporally remodeled ECM alters the resistance force exerted on cells using microfabrication techniques, optical tweezers and mathematical models. The authors demonstrate that active remodeling of the microenvironment modulates force exerted on cells by the ECM...

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Autores principales:	Masaya Hagiwara, Hisataka Maruyama, Masakazu Akiyama, Isabel Koh, Fumihito Arai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/79f45506e1df4649b11be0d8b26b8656
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spelling	oai:doaj.org-article:79f45506e1df4649b11be0d8b26b86562021-12-02T16:10:32ZWeakening of resistance force by cell–ECM interactions regulate cell migration directionality and pattern formation10.1038/s42003-021-02350-42399-3642https://doaj.org/article/79f45506e1df4649b11be0d8b26b86562021-06-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02350-4https://doaj.org/toc/2399-3642Hagiwara et al. investigate how spatio-temporally remodeled ECM alters the resistance force exerted on cells using microfabrication techniques, optical tweezers and mathematical models. The authors demonstrate that active remodeling of the microenvironment modulates force exerted on cells by the ECM, contributing to directionality and pattern formation.Masaya HagiwaraHisataka MaruyamaMasakazu AkiyamaIsabel KohFumihito AraiNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Masaya Hagiwara Hisataka Maruyama Masakazu Akiyama Isabel Koh Fumihito Arai Weakening of resistance force by cell–ECM interactions regulate cell migration directionality and pattern formation
description	Hagiwara et al. investigate how spatio-temporally remodeled ECM alters the resistance force exerted on cells using microfabrication techniques, optical tweezers and mathematical models. The authors demonstrate that active remodeling of the microenvironment modulates force exerted on cells by the ECM, contributing to directionality and pattern formation.
format	article
author	Masaya Hagiwara Hisataka Maruyama Masakazu Akiyama Isabel Koh Fumihito Arai
author_facet	Masaya Hagiwara Hisataka Maruyama Masakazu Akiyama Isabel Koh Fumihito Arai
author_sort	Masaya Hagiwara
title	Weakening of resistance force by cell–ECM interactions regulate cell migration directionality and pattern formation
title_short	Weakening of resistance force by cell–ECM interactions regulate cell migration directionality and pattern formation
title_full	Weakening of resistance force by cell–ECM interactions regulate cell migration directionality and pattern formation
title_fullStr	Weakening of resistance force by cell–ECM interactions regulate cell migration directionality and pattern formation
title_full_unstemmed	Weakening of resistance force by cell–ECM interactions regulate cell migration directionality and pattern formation
title_sort	weakening of resistance force by cell–ecm interactions regulate cell migration directionality and pattern formation
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/79f45506e1df4649b11be0d8b26b8656
work_keys_str_mv	AT masayahagiwara weakeningofresistanceforcebycellecminteractionsregulatecellmigrationdirectionalityandpatternformation AT hisatakamaruyama weakeningofresistanceforcebycellecminteractionsregulatecellmigrationdirectionalityandpatternformation AT masakazuakiyama weakeningofresistanceforcebycellecminteractionsregulatecellmigrationdirectionalityandpatternformation AT isabelkoh weakeningofresistanceforcebycellecminteractionsregulatecellmigrationdirectionalityandpatternformation AT fumihitoarai weakeningofresistanceforcebycellecminteractionsregulatecellmigrationdirectionalityandpatternformation
_version_	1718384417931526144

Weakening of resistance force by cell–ECM interactions regulate cell migration directionality and pattern formation

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