Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. I. Parasitological, hematological and pathological parameters.

African trypanosomiasis is a severe parasitic disease that affects both humans and livestock. Several different species may cause animal trypanosomosis and although Trypanosoma vivax (sub-genus Duttonella) is currently responsible for the vast majority of debilitating cases causing great economic ha...

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Autores principales:	Nathalie Chamond, Alain Cosson, Marie Christine Blom-Potar, Grégory Jouvion, Simon D'Archivio, Mathieu Medina, Sabrina Droin-Bergère, Michel Huerre, Sophie Goyard, Paola Minoprio
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/79f6d12ff3ec46cfa7612ae520074c8e
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spelling	oai:doaj.org-article:79f6d12ff3ec46cfa7612ae520074c8e2021-11-18T09:12:23ZTrypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. I. Parasitological, hematological and pathological parameters.1935-27271935-273510.1371/journal.pntd.0000792https://doaj.org/article/79f6d12ff3ec46cfa7612ae520074c8e2010-08-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20706595/?tool=EBIhttps://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735African trypanosomiasis is a severe parasitic disease that affects both humans and livestock. Several different species may cause animal trypanosomosis and although Trypanosoma vivax (sub-genus Duttonella) is currently responsible for the vast majority of debilitating cases causing great economic hardship in West Africa and South America, little is known about its biology and interaction with its hosts. Relatively speaking, T. vivax has been more than neglected despite an urgent need to develop efficient control strategies. Some pioneering rodent models were developed to circumvent the difficulties of working with livestock, but disappointedly were for the most part discontinued decades ago. To gain more insight into the biology of T. vivax, its interactions with the host and consequently its pathogenesis, we have developed a number of reproducible murine models using a parasite isolate that is infectious for rodents. Firstly, we analyzed the parasitical characteristics of the infection using inbred and outbred mouse strains to compare the impact of host genetic background on the infection and on survival rates. Hematological studies showed that the infection gave rise to severe anemia, and histopathological investigations in various organs showed multifocal inflammatory infiltrates associated with extramedullary hematopoiesis in the liver, and cerebral edema. The models developed are consistent with field observations and pave the way for subsequent in-depth studies into the pathogenesis of T. vivax - trypanosomosis.Nathalie ChamondAlain CossonMarie Christine Blom-PotarGrégory JouvionSimon D'ArchivioMathieu MedinaSabrina Droin-BergèreMichel HuerreSophie GoyardPaola MinoprioPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 4, Iss 8, p e792 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Nathalie Chamond Alain Cosson Marie Christine Blom-Potar Grégory Jouvion Simon D'Archivio Mathieu Medina Sabrina Droin-Bergère Michel Huerre Sophie Goyard Paola Minoprio Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. I. Parasitological, hematological and pathological parameters.
description	African trypanosomiasis is a severe parasitic disease that affects both humans and livestock. Several different species may cause animal trypanosomosis and although Trypanosoma vivax (sub-genus Duttonella) is currently responsible for the vast majority of debilitating cases causing great economic hardship in West Africa and South America, little is known about its biology and interaction with its hosts. Relatively speaking, T. vivax has been more than neglected despite an urgent need to develop efficient control strategies. Some pioneering rodent models were developed to circumvent the difficulties of working with livestock, but disappointedly were for the most part discontinued decades ago. To gain more insight into the biology of T. vivax, its interactions with the host and consequently its pathogenesis, we have developed a number of reproducible murine models using a parasite isolate that is infectious for rodents. Firstly, we analyzed the parasitical characteristics of the infection using inbred and outbred mouse strains to compare the impact of host genetic background on the infection and on survival rates. Hematological studies showed that the infection gave rise to severe anemia, and histopathological investigations in various organs showed multifocal inflammatory infiltrates associated with extramedullary hematopoiesis in the liver, and cerebral edema. The models developed are consistent with field observations and pave the way for subsequent in-depth studies into the pathogenesis of T. vivax - trypanosomosis.
format	article
author	Nathalie Chamond Alain Cosson Marie Christine Blom-Potar Grégory Jouvion Simon D'Archivio Mathieu Medina Sabrina Droin-Bergère Michel Huerre Sophie Goyard Paola Minoprio
author_facet	Nathalie Chamond Alain Cosson Marie Christine Blom-Potar Grégory Jouvion Simon D'Archivio Mathieu Medina Sabrina Droin-Bergère Michel Huerre Sophie Goyard Paola Minoprio
author_sort	Nathalie Chamond
title	Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. I. Parasitological, hematological and pathological parameters.
title_short	Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. I. Parasitological, hematological and pathological parameters.
title_full	Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. I. Parasitological, hematological and pathological parameters.
title_fullStr	Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. I. Parasitological, hematological and pathological parameters.
title_full_unstemmed	Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. I. Parasitological, hematological and pathological parameters.
title_sort	trypanosoma vivax infections: pushing ahead with mouse models for the study of nagana. i. parasitological, hematological and pathological parameters.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/79f6d12ff3ec46cfa7612ae520074c8e
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Trypanosoma vivax infections: pushing ahead with mouse models for the study of Nagana. I. Parasitological, hematological and pathological parameters.

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