Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy

The dentate gyrus is involved in synchronous discharges and seizures, but its microcircuit functional organization in TLE is unclear. Here, the authors show that interictal discharges recruit specific granule cell ensembles dominated by adult-born immature neurons.

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Main Authors:	F. T. Sparks, Z. Liao, W. Li, A. Grosmark, I. Soltesz, A. Losonczy
Format:	article
Language:	EN
Published:	Nature Portfolio 2020
Subjects:	Science Q
Online Access:	https://doaj.org/article/79f6dfb6b4a54b528d85c5ecdce750ee
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id	oai:doaj.org-article:79f6dfb6b4a54b528d85c5ecdce750ee
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spelling	oai:doaj.org-article:79f6dfb6b4a54b528d85c5ecdce750ee2021-12-02T17:32:44ZHippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy10.1038/s41467-020-19969-22041-1723https://doaj.org/article/79f6dfb6b4a54b528d85c5ecdce750ee2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19969-2https://doaj.org/toc/2041-1723The dentate gyrus is involved in synchronous discharges and seizures, but its microcircuit functional organization in TLE is unclear. Here, the authors show that interictal discharges recruit specific granule cell ensembles dominated by adult-born immature neurons.F. T. SparksZ. LiaoW. LiA. GrosmarkI. SolteszA. LosonczyNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q F. T. Sparks Z. Liao W. Li A. Grosmark I. Soltesz A. Losonczy Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy
description	The dentate gyrus is involved in synchronous discharges and seizures, but its microcircuit functional organization in TLE is unclear. Here, the authors show that interictal discharges recruit specific granule cell ensembles dominated by adult-born immature neurons.
format	article
author	F. T. Sparks Z. Liao W. Li A. Grosmark I. Soltesz A. Losonczy
author_facet	F. T. Sparks Z. Liao W. Li A. Grosmark I. Soltesz A. Losonczy
author_sort	F. T. Sparks
title	Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy
title_short	Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy
title_full	Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy
title_fullStr	Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy
title_full_unstemmed	Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy
title_sort	hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/79f6dfb6b4a54b528d85c5ecdce750ee
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Hippocampal adult-born granule cells drive network activity in a mouse model of chronic temporal lobe epilepsy

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