The Mitochondrial-Associated Endoplasmic Reticulum Membrane and Its Role in Diabetic Nephropathy

The mitochondrial-associated endoplasmic reticulum membrane (MAM) is located between the outer mitochondrial membrane and the endoplasmic reticulum membrane. The MAM is involved in a wide range of cellular functions, including calcium signaling, the division and fusion of mitochondria, endoplasmic r...

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Autores principales:	Lihua Ni, Cheng Yuan
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Cytology QH573-671
Acceso en línea:	https://doaj.org/article/79f7440416174640a36de8f1a6520148
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spelling	oai:doaj.org-article:79f7440416174640a36de8f1a65201482021-11-15T01:19:35ZThe Mitochondrial-Associated Endoplasmic Reticulum Membrane and Its Role in Diabetic Nephropathy1942-099410.1155/2021/8054817https://doaj.org/article/79f7440416174640a36de8f1a65201482021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/8054817https://doaj.org/toc/1942-0994The mitochondrial-associated endoplasmic reticulum membrane (MAM) is located between the outer mitochondrial membrane and the endoplasmic reticulum membrane. The MAM is involved in a wide range of cellular functions, including calcium signaling, the division and fusion of mitochondria, endoplasmic reticulum stress, and the synthesis and transport of lipids. Recent studies have discovered that the MAM is involved in the pathogenesis of diabetic nephropathy (DN). In this article, we summarize the structure, function and role of the MAM in DN. We hope this study will provide clues and a theoretical basis for mechanistic and targeted drug research on DN.Lihua NiCheng YuanHindawi LimitedarticleCytologyQH573-671ENOxidative Medicine and Cellular Longevity, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Cytology QH573-671
spellingShingle	Cytology QH573-671 Lihua Ni Cheng Yuan The Mitochondrial-Associated Endoplasmic Reticulum Membrane and Its Role in Diabetic Nephropathy
description	The mitochondrial-associated endoplasmic reticulum membrane (MAM) is located between the outer mitochondrial membrane and the endoplasmic reticulum membrane. The MAM is involved in a wide range of cellular functions, including calcium signaling, the division and fusion of mitochondria, endoplasmic reticulum stress, and the synthesis and transport of lipids. Recent studies have discovered that the MAM is involved in the pathogenesis of diabetic nephropathy (DN). In this article, we summarize the structure, function and role of the MAM in DN. We hope this study will provide clues and a theoretical basis for mechanistic and targeted drug research on DN.
format	article
author	Lihua Ni Cheng Yuan
author_facet	Lihua Ni Cheng Yuan
author_sort	Lihua Ni
title	The Mitochondrial-Associated Endoplasmic Reticulum Membrane and Its Role in Diabetic Nephropathy
title_short	The Mitochondrial-Associated Endoplasmic Reticulum Membrane and Its Role in Diabetic Nephropathy
title_full	The Mitochondrial-Associated Endoplasmic Reticulum Membrane and Its Role in Diabetic Nephropathy
title_fullStr	The Mitochondrial-Associated Endoplasmic Reticulum Membrane and Its Role in Diabetic Nephropathy
title_full_unstemmed	The Mitochondrial-Associated Endoplasmic Reticulum Membrane and Its Role in Diabetic Nephropathy
title_sort	mitochondrial-associated endoplasmic reticulum membrane and its role in diabetic nephropathy
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/79f7440416174640a36de8f1a6520148
work_keys_str_mv	AT lihuani themitochondrialassociatedendoplasmicreticulummembraneanditsroleindiabeticnephropathy AT chengyuan themitochondrialassociatedendoplasmicreticulummembraneanditsroleindiabeticnephropathy AT lihuani mitochondrialassociatedendoplasmicreticulummembraneanditsroleindiabeticnephropathy AT chengyuan mitochondrialassociatedendoplasmicreticulummembraneanditsroleindiabeticnephropathy
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The Mitochondrial-Associated Endoplasmic Reticulum Membrane and Its Role in Diabetic Nephropathy

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