Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site

Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site

The SARS-CoV-2 main protease (Mpro) is one of two cysteine proteases essential for viral replication. Here, the authors determine the crystal structure of an Mpro acyl intermediate with its native C-terminal autocleavage sequence and the structure of a product bound active site mutant (C145A), which...

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Autores principales: Jaeyong Lee, Liam J. Worrall, Marija Vuckovic, Federico I. Rosell, Francesco Gentile, Anh-Tien Ton, Nathanael A. Caveney, Fuqiang Ban, Artem Cherkasov, Mark Paetzel, Natalie C. J. Strynadka
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
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Acceso en línea:https://doaj.org/article/79fa01c0d7f04a9ab66a27ea9f850fb5
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