Species-specific antifungal activity of blue light

Abstract Fungal pathogens represent a significant threat to immunocompromised patients or individuals with traumatic injury. Strategies to efficiently remove fungal spores from hospital surfaces and, ideally, patient skin thus offer the prospect of dramatically reducing infections in at-risk patient...

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Autores principales:	Wioleta J. Trzaska, Helen E. Wrigley, Joanne E. Thwaite, Robin C. May
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/79fb355c4d6040ecad03452d77f9c993
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spelling	oai:doaj.org-article:79fb355c4d6040ecad03452d77f9c9932021-12-02T16:06:58ZSpecies-specific antifungal activity of blue light10.1038/s41598-017-05000-02045-2322https://doaj.org/article/79fb355c4d6040ecad03452d77f9c9932017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-05000-0https://doaj.org/toc/2045-2322Abstract Fungal pathogens represent a significant threat to immunocompromised patients or individuals with traumatic injury. Strategies to efficiently remove fungal spores from hospital surfaces and, ideally, patient skin thus offer the prospect of dramatically reducing infections in at-risk patients. Photodynamic inactivation of microbial cells using light holds considerable potential as a non-invasive, minimally destructive disinfection strategy. Recent data indicate that high-intensity blue light effectively removes bacteria from surfaces, but its efficacy against fungi has not been fully tested. Here we test a wide range of fungi that are pathogenic to humans and demonstrate that blue light is effective against some, but not all, fungal species. We additionally note that secondary heating effects are a previously unrecognized confounding factor in establishing the antimicrobial activity of blue light. Thus blue light holds promise for the sterilization of clinical surfaces, but requires further optimization prior to widespread use.Wioleta J. TrzaskaHelen E. WrigleyJoanne E. ThwaiteRobin C. MayNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Wioleta J. Trzaska Helen E. Wrigley Joanne E. Thwaite Robin C. May Species-specific antifungal activity of blue light
description	Abstract Fungal pathogens represent a significant threat to immunocompromised patients or individuals with traumatic injury. Strategies to efficiently remove fungal spores from hospital surfaces and, ideally, patient skin thus offer the prospect of dramatically reducing infections in at-risk patients. Photodynamic inactivation of microbial cells using light holds considerable potential as a non-invasive, minimally destructive disinfection strategy. Recent data indicate that high-intensity blue light effectively removes bacteria from surfaces, but its efficacy against fungi has not been fully tested. Here we test a wide range of fungi that are pathogenic to humans and demonstrate that blue light is effective against some, but not all, fungal species. We additionally note that secondary heating effects are a previously unrecognized confounding factor in establishing the antimicrobial activity of blue light. Thus blue light holds promise for the sterilization of clinical surfaces, but requires further optimization prior to widespread use.
format	article
author	Wioleta J. Trzaska Helen E. Wrigley Joanne E. Thwaite Robin C. May
author_facet	Wioleta J. Trzaska Helen E. Wrigley Joanne E. Thwaite Robin C. May
author_sort	Wioleta J. Trzaska
title	Species-specific antifungal activity of blue light
title_short	Species-specific antifungal activity of blue light
title_full	Species-specific antifungal activity of blue light
title_fullStr	Species-specific antifungal activity of blue light
title_full_unstemmed	Species-specific antifungal activity of blue light
title_sort	species-specific antifungal activity of blue light
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/79fb355c4d6040ecad03452d77f9c993
work_keys_str_mv	AT wioletajtrzaska speciesspecificantifungalactivityofbluelight AT helenewrigley speciesspecificantifungalactivityofbluelight AT joanneethwaite speciesspecificantifungalactivityofbluelight AT robincmay speciesspecificantifungalactivityofbluelight
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Species-specific antifungal activity of blue light

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