The molecular basis for SARS-CoV-2 binding to dog ACE2

The molecular basis for SARS-CoV-2 binding to dog ACE2

Many domestic animals, among them dogs, have been infected with SARS-CoV-2 during the COVID-19 pandemic. Here, the authors present the crystal structure of the SARS-CoV-2 spike protein receptor binding domain (RBD) bound to its receptor, dog angiotensin-converting enzyme 2 (dACE2), and show that the...

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Autores principales: Zengyuan Zhang, Yanfang Zhang, Kefang Liu, Yan Li, Qiong Lu, Qingling Wang, Yuqin Zhang, Liang Wang, Hanyi Liao, Anqi Zheng, Sufang Ma, Zheng Fan, Huifang Li, Weijin Huang, Yuhai Bi, Xin Zhao, Qihui Wang, George F. Gao, Haixia Xiao, Zhou Tong, Jianxun Qi, Yeping Sun
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/79fdbab038eb40bfba09615269e6e989
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Sumario:Many domestic animals, among them dogs, have been infected with SARS-CoV-2 during the COVID-19 pandemic. Here, the authors present the crystal structure of the SARS-CoV-2 spike protein receptor binding domain (RBD) bound to its receptor, dog angiotensin-converting enzyme 2 (dACE2), and show that the RBD N501Y mutation increases the infectivity and host range of SARS-CoV-2, which highlights the need to monitor emerging SARS-CoV-2 mutations in domestic animals.

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