The molecular basis for SARS-CoV-2 binding to dog ACE2
Many domestic animals, among them dogs, have been infected with SARS-CoV-2 during the COVID-19 pandemic. Here, the authors present the crystal structure of the SARS-CoV-2 spike protein receptor binding domain (RBD) bound to its receptor, dog angiotensin-converting enzyme 2 (dACE2), and show that the...
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Nature Portfolio
2021
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oai:doaj.org-article:79fdbab038eb40bfba09615269e6e9892021-12-02T16:14:57ZThe molecular basis for SARS-CoV-2 binding to dog ACE210.1038/s41467-021-24326-y2041-1723https://doaj.org/article/79fdbab038eb40bfba09615269e6e9892021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24326-yhttps://doaj.org/toc/2041-1723Many domestic animals, among them dogs, have been infected with SARS-CoV-2 during the COVID-19 pandemic. Here, the authors present the crystal structure of the SARS-CoV-2 spike protein receptor binding domain (RBD) bound to its receptor, dog angiotensin-converting enzyme 2 (dACE2), and show that the RBD N501Y mutation increases the infectivity and host range of SARS-CoV-2, which highlights the need to monitor emerging SARS-CoV-2 mutations in domestic animals.Zengyuan ZhangYanfang ZhangKefang LiuYan LiQiong LuQingling WangYuqin ZhangLiang WangHanyi LiaoAnqi ZhengSufang MaZheng FanHuifang LiWeijin HuangYuhai BiXin ZhaoQihui WangGeorge F. GaoHaixia XiaoZhou TongJianxun QiYeping SunNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-10 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Zengyuan Zhang Yanfang Zhang Kefang Liu Yan Li Qiong Lu Qingling Wang Yuqin Zhang Liang Wang Hanyi Liao Anqi Zheng Sufang Ma Zheng Fan Huifang Li Weijin Huang Yuhai Bi Xin Zhao Qihui Wang George F. Gao Haixia Xiao Zhou Tong Jianxun Qi Yeping Sun The molecular basis for SARS-CoV-2 binding to dog ACE2 |
| description |
Many domestic animals, among them dogs, have been infected with SARS-CoV-2 during the COVID-19 pandemic. Here, the authors present the crystal structure of the SARS-CoV-2 spike protein receptor binding domain (RBD) bound to its receptor, dog angiotensin-converting enzyme 2 (dACE2), and show that the RBD N501Y mutation increases the infectivity and host range of SARS-CoV-2, which highlights the need to monitor emerging SARS-CoV-2 mutations in domestic animals. |
| format |
article |
| author |
Zengyuan Zhang Yanfang Zhang Kefang Liu Yan Li Qiong Lu Qingling Wang Yuqin Zhang Liang Wang Hanyi Liao Anqi Zheng Sufang Ma Zheng Fan Huifang Li Weijin Huang Yuhai Bi Xin Zhao Qihui Wang George F. Gao Haixia Xiao Zhou Tong Jianxun Qi Yeping Sun |
| author_facet |
Zengyuan Zhang Yanfang Zhang Kefang Liu Yan Li Qiong Lu Qingling Wang Yuqin Zhang Liang Wang Hanyi Liao Anqi Zheng Sufang Ma Zheng Fan Huifang Li Weijin Huang Yuhai Bi Xin Zhao Qihui Wang George F. Gao Haixia Xiao Zhou Tong Jianxun Qi Yeping Sun |
| author_sort |
Zengyuan Zhang |
| title |
The molecular basis for SARS-CoV-2 binding to dog ACE2 |
| title_short |
The molecular basis for SARS-CoV-2 binding to dog ACE2 |
| title_full |
The molecular basis for SARS-CoV-2 binding to dog ACE2 |
| title_fullStr |
The molecular basis for SARS-CoV-2 binding to dog ACE2 |
| title_full_unstemmed |
The molecular basis for SARS-CoV-2 binding to dog ACE2 |
| title_sort |
molecular basis for sars-cov-2 binding to dog ace2 |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/79fdbab038eb40bfba09615269e6e989 |
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