Blackcurrant Improves Diabetic Cardiovascular Dysfunction by Reducing Inflammatory Cytokines in Type 2 Diabetes Mellitus Mice

Diabetic cardiovascular dysfunction is a representative complication of diabetes. Inflammation associated with the onset and exacerbation of type 2 diabetes mellitus (T2DM) is an essential factor in the pathogenesis of diabetic cardiovascular complications. Diabetes-induced myocardial dysfunction is...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hye-Yoom Kim, Jung-Joo Yoon, Hyeon-Kyoung Lee, Ai-Lin Tai, Yun-Jung Lee, Dae-Sung Kim, Dae-Gill Kang, Ho-Sub Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	blackcurrant type 2 diabetes mellitus diabetic cardiomyopathy cardiovascular inflammation Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/7a041e2f1cda4769a24dceb49954eab1
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7a041e2f1cda4769a24dceb49954eab1
record_format	dspace
spelling	oai:doaj.org-article:7a041e2f1cda4769a24dceb49954eab12021-11-25T18:37:22ZBlackcurrant Improves Diabetic Cardiovascular Dysfunction by Reducing Inflammatory Cytokines in Type 2 Diabetes Mellitus Mice10.3390/nu131141772072-6643https://doaj.org/article/7a041e2f1cda4769a24dceb49954eab12021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/4177https://doaj.org/toc/2072-6643Diabetic cardiovascular dysfunction is a representative complication of diabetes. Inflammation associated with the onset and exacerbation of type 2 diabetes mellitus (T2DM) is an essential factor in the pathogenesis of diabetic cardiovascular complications. Diabetes-induced myocardial dysfunction is characterized by myocardial fibrosis, which includes structural heart changes, myocardial cell death, and extracellular matrix protein accumulation. The mice groups in this study were divided as follows: Cont, control (db/m mice); T2DM, type 2 diabetes mellitus mice (db/db mice); Vil.G, db/db + vildagliptin 50 mg/kg/day, positive control, dipeptidyl peptidase-4 (DPP-4) inhibitor; Bla.C, db/db + blackcurrant 200 mg/kg/day. In this study, Bla.C treatment significantly improved the homeostatic model evaluation of glucose, insulin, and insulin resistance (HOMA-IR) indices and diabetic blood markers such as HbA1c in T2DM mice. In addition, Bla.C improved cardiac function markers and cardiac thickening through echocardiography. Bla.C reduced the expression of fibrosis biomarkers, elastin and type IV collagen, in the left ventricle of a diabetic cardiopathy model. Bla.C also inhibited TD2M-induced elevated levels of inflammatory cytokines in cardiac tissue (IL-6, IL-1β, TNF-α, and TGF-β). Thus, Bla.C significantly improved cardiac inflammation and cardiovascular fibrosis and dysfunction by blocking inflammatory cytokine activation signals. This showed that Bla.C treatment could ameliorate diabetes-induced cardiovascular complications in T2DM mice. These results provide evidence that Bla.C extract has a significant effect on the prevention of cardiovascular fibrosis, inflammation, and consequent diabetes-induced cardiovascular complications, directly or indirectly, by improving blood glucose profile.Hye-Yoom KimJung-Joo YoonHyeon-Kyoung LeeAi-Lin TaiYun-Jung LeeDae-Sung KimDae-Gill KangHo-Sub LeeMDPI AGarticleblackcurranttype 2 diabetes mellitusdiabetic cardiomyopathycardiovascularinflammationNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 4177, p 4177 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blackcurrant type 2 diabetes mellitus diabetic cardiomyopathy cardiovascular inflammation Nutrition. Foods and food supply TX341-641
spellingShingle	blackcurrant type 2 diabetes mellitus diabetic cardiomyopathy cardiovascular inflammation Nutrition. Foods and food supply TX341-641 Hye-Yoom Kim Jung-Joo Yoon Hyeon-Kyoung Lee Ai-Lin Tai Yun-Jung Lee Dae-Sung Kim Dae-Gill Kang Ho-Sub Lee Blackcurrant Improves Diabetic Cardiovascular Dysfunction by Reducing Inflammatory Cytokines in Type 2 Diabetes Mellitus Mice
description	Diabetic cardiovascular dysfunction is a representative complication of diabetes. Inflammation associated with the onset and exacerbation of type 2 diabetes mellitus (T2DM) is an essential factor in the pathogenesis of diabetic cardiovascular complications. Diabetes-induced myocardial dysfunction is characterized by myocardial fibrosis, which includes structural heart changes, myocardial cell death, and extracellular matrix protein accumulation. The mice groups in this study were divided as follows: Cont, control (db/m mice); T2DM, type 2 diabetes mellitus mice (db/db mice); Vil.G, db/db + vildagliptin 50 mg/kg/day, positive control, dipeptidyl peptidase-4 (DPP-4) inhibitor; Bla.C, db/db + blackcurrant 200 mg/kg/day. In this study, Bla.C treatment significantly improved the homeostatic model evaluation of glucose, insulin, and insulin resistance (HOMA-IR) indices and diabetic blood markers such as HbA1c in T2DM mice. In addition, Bla.C improved cardiac function markers and cardiac thickening through echocardiography. Bla.C reduced the expression of fibrosis biomarkers, elastin and type IV collagen, in the left ventricle of a diabetic cardiopathy model. Bla.C also inhibited TD2M-induced elevated levels of inflammatory cytokines in cardiac tissue (IL-6, IL-1β, TNF-α, and TGF-β). Thus, Bla.C significantly improved cardiac inflammation and cardiovascular fibrosis and dysfunction by blocking inflammatory cytokine activation signals. This showed that Bla.C treatment could ameliorate diabetes-induced cardiovascular complications in T2DM mice. These results provide evidence that Bla.C extract has a significant effect on the prevention of cardiovascular fibrosis, inflammation, and consequent diabetes-induced cardiovascular complications, directly or indirectly, by improving blood glucose profile.
format	article
author	Hye-Yoom Kim Jung-Joo Yoon Hyeon-Kyoung Lee Ai-Lin Tai Yun-Jung Lee Dae-Sung Kim Dae-Gill Kang Ho-Sub Lee
author_facet	Hye-Yoom Kim Jung-Joo Yoon Hyeon-Kyoung Lee Ai-Lin Tai Yun-Jung Lee Dae-Sung Kim Dae-Gill Kang Ho-Sub Lee
author_sort	Hye-Yoom Kim
title	Blackcurrant Improves Diabetic Cardiovascular Dysfunction by Reducing Inflammatory Cytokines in Type 2 Diabetes Mellitus Mice
title_short	Blackcurrant Improves Diabetic Cardiovascular Dysfunction by Reducing Inflammatory Cytokines in Type 2 Diabetes Mellitus Mice
title_full	Blackcurrant Improves Diabetic Cardiovascular Dysfunction by Reducing Inflammatory Cytokines in Type 2 Diabetes Mellitus Mice
title_fullStr	Blackcurrant Improves Diabetic Cardiovascular Dysfunction by Reducing Inflammatory Cytokines in Type 2 Diabetes Mellitus Mice
title_full_unstemmed	Blackcurrant Improves Diabetic Cardiovascular Dysfunction by Reducing Inflammatory Cytokines in Type 2 Diabetes Mellitus Mice
title_sort	blackcurrant improves diabetic cardiovascular dysfunction by reducing inflammatory cytokines in type 2 diabetes mellitus mice
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/7a041e2f1cda4769a24dceb49954eab1
work_keys_str_mv	AT hyeyoomkim blackcurrantimprovesdiabeticcardiovasculardysfunctionbyreducinginflammatorycytokinesintype2diabetesmellitusmice AT jungjooyoon blackcurrantimprovesdiabeticcardiovasculardysfunctionbyreducinginflammatorycytokinesintype2diabetesmellitusmice AT hyeonkyounglee blackcurrantimprovesdiabeticcardiovasculardysfunctionbyreducinginflammatorycytokinesintype2diabetesmellitusmice AT ailintai blackcurrantimprovesdiabeticcardiovasculardysfunctionbyreducinginflammatorycytokinesintype2diabetesmellitusmice AT yunjunglee blackcurrantimprovesdiabeticcardiovasculardysfunctionbyreducinginflammatorycytokinesintype2diabetesmellitusmice AT daesungkim blackcurrantimprovesdiabeticcardiovasculardysfunctionbyreducinginflammatorycytokinesintype2diabetesmellitusmice AT daegillkang blackcurrantimprovesdiabeticcardiovasculardysfunctionbyreducinginflammatorycytokinesintype2diabetesmellitusmice AT hosublee blackcurrantimprovesdiabeticcardiovasculardysfunctionbyreducinginflammatorycytokinesintype2diabetesmellitusmice
_version_	1718410898875351040

Blackcurrant Improves Diabetic Cardiovascular Dysfunction by Reducing Inflammatory Cytokines in Type 2 Diabetes Mellitus Mice

Ejemplares similares