Identification of HIV-1 Vif regions required for CBF-β interaction and APOBEC3 suppression.

Human immunodeficiency virus type 1 (HIV-1) Vif requires core binding factor β (CBF-β) to degrade the host APOBEC3 restriction factors. Although a minimum domain and certain amino acids of HIV-1 Vif, including hydrophobic residues at the N-terminal, have been identified as critical sites for binding...

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Autores principales: Hong Wang, Bin Liu, Xin Liu, Zhaolong Li, Xiao-Fang Yu, Wenyan Zhang
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
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Acceso en línea:https://doaj.org/article/7a043925c0e3487eab6fbd8124773c1f
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