Glutamic acid promotes hair growth in mice

Abstract Glutamic acid is the main excitatory neurotransmitter acting both in the brain and in peripheral tissues. Abnormal distribution of glutamic acid receptors occurs in skin hyperproliferative conditions such as psoriasis and skin regeneration; however, the biological function of glutamic acid...

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Autores principales:	Carlos Poblete Jara, Beatriz de Andrade Berti, Natália Ferreira Mendes, Daiane Fátima Engel, Ariane Maria Zanesco, Gabriela Freitas Pereira de Souza, Renan de Medeiros Bezerra, Julia de Toledo Bagatin, Silvya Stuchi Maria-Engler, Joseane Morari, William H. Velander, Lício A. Velloso, Eliana Pereira Araújo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7a05eb7d4bce492ead6effd029af47b2
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spelling	oai:doaj.org-article:7a05eb7d4bce492ead6effd029af47b22021-12-02T18:47:07ZGlutamic acid promotes hair growth in mice10.1038/s41598-021-94816-y2045-2322https://doaj.org/article/7a05eb7d4bce492ead6effd029af47b22021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-94816-yhttps://doaj.org/toc/2045-2322Abstract Glutamic acid is the main excitatory neurotransmitter acting both in the brain and in peripheral tissues. Abnormal distribution of glutamic acid receptors occurs in skin hyperproliferative conditions such as psoriasis and skin regeneration; however, the biological function of glutamic acid in the skin remains unclear. Using ex vivo, in vivo and in silico approaches, we showed that exogenous glutamic acid promotes hair growth and keratinocyte proliferation. Topical application of glutamic acid decreased the expression of genes related to apoptosis in the skin, whereas glutamic acid increased cell viability and proliferation in human keratinocyte cultures. In addition, we identified the keratinocyte glutamic acid excitotoxic concentration, providing evidence for the existence of a novel skin signalling pathway mediated by a neurotransmitter that controls keratinocyte and hair follicle proliferation. Thus, glutamic acid emerges as a component of the peripheral nervous system that acts to control cell growth in the skin. These results raise the perspective of the pharmacological and nutritional use of glutamic acid to treat skin diseases.Carlos Poblete JaraBeatriz de Andrade BertiNatália Ferreira MendesDaiane Fátima EngelAriane Maria ZanescoGabriela Freitas Pereira de SouzaRenan de Medeiros BezerraJulia de Toledo BagatinSilvya Stuchi Maria-EnglerJoseane MorariWilliam H. VelanderLício A. VellosoEliana Pereira AraújoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Carlos Poblete Jara Beatriz de Andrade Berti Natália Ferreira Mendes Daiane Fátima Engel Ariane Maria Zanesco Gabriela Freitas Pereira de Souza Renan de Medeiros Bezerra Julia de Toledo Bagatin Silvya Stuchi Maria-Engler Joseane Morari William H. Velander Lício A. Velloso Eliana Pereira Araújo Glutamic acid promotes hair growth in mice
description	Abstract Glutamic acid is the main excitatory neurotransmitter acting both in the brain and in peripheral tissues. Abnormal distribution of glutamic acid receptors occurs in skin hyperproliferative conditions such as psoriasis and skin regeneration; however, the biological function of glutamic acid in the skin remains unclear. Using ex vivo, in vivo and in silico approaches, we showed that exogenous glutamic acid promotes hair growth and keratinocyte proliferation. Topical application of glutamic acid decreased the expression of genes related to apoptosis in the skin, whereas glutamic acid increased cell viability and proliferation in human keratinocyte cultures. In addition, we identified the keratinocyte glutamic acid excitotoxic concentration, providing evidence for the existence of a novel skin signalling pathway mediated by a neurotransmitter that controls keratinocyte and hair follicle proliferation. Thus, glutamic acid emerges as a component of the peripheral nervous system that acts to control cell growth in the skin. These results raise the perspective of the pharmacological and nutritional use of glutamic acid to treat skin diseases.
format	article
author	Carlos Poblete Jara Beatriz de Andrade Berti Natália Ferreira Mendes Daiane Fátima Engel Ariane Maria Zanesco Gabriela Freitas Pereira de Souza Renan de Medeiros Bezerra Julia de Toledo Bagatin Silvya Stuchi Maria-Engler Joseane Morari William H. Velander Lício A. Velloso Eliana Pereira Araújo
author_facet	Carlos Poblete Jara Beatriz de Andrade Berti Natália Ferreira Mendes Daiane Fátima Engel Ariane Maria Zanesco Gabriela Freitas Pereira de Souza Renan de Medeiros Bezerra Julia de Toledo Bagatin Silvya Stuchi Maria-Engler Joseane Morari William H. Velander Lício A. Velloso Eliana Pereira Araújo
author_sort	Carlos Poblete Jara
title	Glutamic acid promotes hair growth in mice
title_short	Glutamic acid promotes hair growth in mice
title_full	Glutamic acid promotes hair growth in mice
title_fullStr	Glutamic acid promotes hair growth in mice
title_full_unstemmed	Glutamic acid promotes hair growth in mice
title_sort	glutamic acid promotes hair growth in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7a05eb7d4bce492ead6effd029af47b2
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Glutamic acid promotes hair growth in mice

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