MicroRNA-Based Biomarkers in the Diagnosis and Monitoring of Therapeutic Response in Patients with Depression

Ya-Yun Xu,1–4 Qian-Hui Xia,5 Qing-Rong Xia,1,3,4 Xu-Lai Zhang,6,7 Jun Liang1,3,4 1Department of Pharmacy, Hefei Fourth People’s Hospital, Hefei 230000, People’s Republic of China; 2CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xu YY, Xia QH, Xia QR, Zhang XL, Liang J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	depression microrna biomarker diagnosis therapy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/7a0676dff8874d03b7759ba96a807377
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:7a0676dff8874d03b7759ba96a807377
record_format	dspace
spelling	oai:doaj.org-article:7a0676dff8874d03b7759ba96a8073772021-12-02T06:24:13ZMicroRNA-Based Biomarkers in the Diagnosis and Monitoring of Therapeutic Response in Patients with Depression1178-2021https://doaj.org/article/7a0676dff8874d03b7759ba96a8073772019-12-01T00:00:00Zhttps://www.dovepress.com/microrna-based-biomarkers-in-the-diagnosis-and-monitoring-of-therapeut-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Ya-Yun Xu,1–4 Qian-Hui Xia,5 Qing-Rong Xia,1,3,4 Xu-Lai Zhang,6,7 Jun Liang1,3,4 1Department of Pharmacy, Hefei Fourth People’s Hospital, Hefei 230000, People’s Republic of China; 2CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei 230022, People’s Republic of China; 3Department of Psychopharmacology, Anhui Mental Health Center, Hefei 230000, People’s Republic of China; 4Department of Clinical Pharmacy, Affiliated Psychological Hospital of Anhui Medical University, Hefei 230000, People’s Republic of China; 5School of Pharmacy, Wannan Medical College, Wuhu 241002, People’s Republic of China; 6Department of Geriatric Psychology, Hefei Fourth People’s Hospital, Hefei 230000, People’s Republic of China; 7Clinical School of Mental Health, Anhui Medical University, Hefei 230000, People’s Republic of ChinaCorrespondence: Jun LiangDepartment of Pharmacy, Hefei Fourth People’s Hospital, 316 Huangshan Road, Hefei 230000, People’s Republic of ChinaTel/Fax +86 551 63616022Email amhcliangj@163.comXu-Lai ZhangDepartment of Geriatric Psychology, Hefei Fourth People’s Hospital, 316 Huangshan Road, Hefei 230000, People’s Republic of ChinaTel/Fax +86 551 63616022Email Xulaizhang@ahmhcentre.comAbstract: Depression is a debilitating mental illness that affects up to 120 million people worldwide; it is currently determined based on subjective diagnostic schemes that are limited by high uncertainty. Hence, there is an urgent need to identify effective and reliable biomarkers to increase diagnostic accuracy. MicroRNAs (miRNAs) constitute a recently discovered class of non-coding RNAs that play a key role in the regulation of gene expression by modulating translation, messenger RNA (mRNA) degradation, or stability of mRNA targets. Dysregulated expression of miRNAs is being investigated as a clinical biomarker for a variety of diseases, including depression. Accumulating evidence has shown that miRNAs participate in many aspects of neural plasticity, neurogenesis, and the stress response. This is supported by more direct studies based on human postmortem brain tissue that strongly indicate that miRNAs not only play a key role in the pathogenesis of major depressive disorder, but also present potential for the development of therapeutic targets. miRNAs in the peripheral and central nervous system are being considered as potential biomarkers in the diagnosis of depression and in monitoring the therapeutic response to antidepressants, owing to their stability, tissue-specificity, and disease-specific expression. In this review, we focus on various miRNAs in tissues and fluids that could be employed as diagnostic and therapeutic biomarkers in patients with depression.Keywords: depression, microRNA, biomarker, diagnosis, therapyXu YYXia QHXia QRZhang XLLiang JDove Medical PressarticledepressionmicrornabiomarkerdiagnosistherapyNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 3583-3597 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	depression microrna biomarker diagnosis therapy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	depression microrna biomarker diagnosis therapy Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Xu YY Xia QH Xia QR Zhang XL Liang J MicroRNA-Based Biomarkers in the Diagnosis and Monitoring of Therapeutic Response in Patients with Depression
description	Ya-Yun Xu,1–4 Qian-Hui Xia,5 Qing-Rong Xia,1,3,4 Xu-Lai Zhang,6,7 Jun Liang1,3,4 1Department of Pharmacy, Hefei Fourth People’s Hospital, Hefei 230000, People’s Republic of China; 2CAS Key Laboratory of Brain Function and Disease, University of Science and Technology of China, Hefei 230022, People’s Republic of China; 3Department of Psychopharmacology, Anhui Mental Health Center, Hefei 230000, People’s Republic of China; 4Department of Clinical Pharmacy, Affiliated Psychological Hospital of Anhui Medical University, Hefei 230000, People’s Republic of China; 5School of Pharmacy, Wannan Medical College, Wuhu 241002, People’s Republic of China; 6Department of Geriatric Psychology, Hefei Fourth People’s Hospital, Hefei 230000, People’s Republic of China; 7Clinical School of Mental Health, Anhui Medical University, Hefei 230000, People’s Republic of ChinaCorrespondence: Jun LiangDepartment of Pharmacy, Hefei Fourth People’s Hospital, 316 Huangshan Road, Hefei 230000, People’s Republic of ChinaTel/Fax +86 551 63616022Email amhcliangj@163.comXu-Lai ZhangDepartment of Geriatric Psychology, Hefei Fourth People’s Hospital, 316 Huangshan Road, Hefei 230000, People’s Republic of ChinaTel/Fax +86 551 63616022Email Xulaizhang@ahmhcentre.comAbstract: Depression is a debilitating mental illness that affects up to 120 million people worldwide; it is currently determined based on subjective diagnostic schemes that are limited by high uncertainty. Hence, there is an urgent need to identify effective and reliable biomarkers to increase diagnostic accuracy. MicroRNAs (miRNAs) constitute a recently discovered class of non-coding RNAs that play a key role in the regulation of gene expression by modulating translation, messenger RNA (mRNA) degradation, or stability of mRNA targets. Dysregulated expression of miRNAs is being investigated as a clinical biomarker for a variety of diseases, including depression. Accumulating evidence has shown that miRNAs participate in many aspects of neural plasticity, neurogenesis, and the stress response. This is supported by more direct studies based on human postmortem brain tissue that strongly indicate that miRNAs not only play a key role in the pathogenesis of major depressive disorder, but also present potential for the development of therapeutic targets. miRNAs in the peripheral and central nervous system are being considered as potential biomarkers in the diagnosis of depression and in monitoring the therapeutic response to antidepressants, owing to their stability, tissue-specificity, and disease-specific expression. In this review, we focus on various miRNAs in tissues and fluids that could be employed as diagnostic and therapeutic biomarkers in patients with depression.Keywords: depression, microRNA, biomarker, diagnosis, therapy
format	article
author	Xu YY Xia QH Xia QR Zhang XL Liang J
author_facet	Xu YY Xia QH Xia QR Zhang XL Liang J
author_sort	Xu YY
title	MicroRNA-Based Biomarkers in the Diagnosis and Monitoring of Therapeutic Response in Patients with Depression
title_short	MicroRNA-Based Biomarkers in the Diagnosis and Monitoring of Therapeutic Response in Patients with Depression
title_full	MicroRNA-Based Biomarkers in the Diagnosis and Monitoring of Therapeutic Response in Patients with Depression
title_fullStr	MicroRNA-Based Biomarkers in the Diagnosis and Monitoring of Therapeutic Response in Patients with Depression
title_full_unstemmed	MicroRNA-Based Biomarkers in the Diagnosis and Monitoring of Therapeutic Response in Patients with Depression
title_sort	microrna-based biomarkers in the diagnosis and monitoring of therapeutic response in patients with depression
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/7a0676dff8874d03b7759ba96a807377
work_keys_str_mv	AT xuyy micrornabasedbiomarkersinthediagnosisandmonitoringoftherapeuticresponseinpatientswithdepression AT xiaqh micrornabasedbiomarkersinthediagnosisandmonitoringoftherapeuticresponseinpatientswithdepression AT xiaqr micrornabasedbiomarkersinthediagnosisandmonitoringoftherapeuticresponseinpatientswithdepression AT zhangxl micrornabasedbiomarkersinthediagnosisandmonitoringoftherapeuticresponseinpatientswithdepression AT liangj micrornabasedbiomarkersinthediagnosisandmonitoringoftherapeuticresponseinpatientswithdepression
_version_	1718399943191822336

MicroRNA-Based Biomarkers in the Diagnosis and Monitoring of Therapeutic Response in Patients with Depression

Ejemplares similares