Evaluation of antibacterial properties of polyelectrolyte multilayer coatings by norm tests

Medical implants play a central role in modern medicine and both, naturally derived and synthetic materials have been explored as biomaterials for such devices. However, when implanted into living tissue, most materials initiate a host response. In addition, implants often cause bacterial infections...

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Autores principales:	Djanklich Leyla, Andreeva Tonya, Xiong Xin, Krastev Rumen, Kemkemer Ralf
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	polyelectrolyte multilayer coatings implants antibacterial coating norm tests Medicine R
Acceso en línea:	https://doaj.org/article/7a0bff703c4e40ae873384646b8d4bcb
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id	oai:doaj.org-article:7a0bff703c4e40ae873384646b8d4bcb
record_format	dspace
spelling	oai:doaj.org-article:7a0bff703c4e40ae873384646b8d4bcb2021-12-05T14:10:43ZEvaluation of antibacterial properties of polyelectrolyte multilayer coatings by norm tests2364-550410.1515/cdbme-2020-3122https://doaj.org/article/7a0bff703c4e40ae873384646b8d4bcb2020-09-01T00:00:00Zhttps://doi.org/10.1515/cdbme-2020-3122https://doaj.org/toc/2364-5504Medical implants play a central role in modern medicine and both, naturally derived and synthetic materials have been explored as biomaterials for such devices. However, when implanted into living tissue, most materials initiate a host response. In addition, implants often cause bacterial infections leading to complications. Polyelectrolyte multilayer (PEM) coatings can be used for functionalization of medical implants improving the implant integration and reducing foreign body reactions. Some PEMs are also known to show antibacterial properties. We developed a PEM coating suggesting that it can decrease the risk of bacterial infections occurring after implantation while being highly biocompatible. We applied two different standard tests for evaluating the PEM’s antibacterial properties, the ISO norm (ISO 22196) and one ASTM norm (ASTM E2180) test. We found a reduction of bacterial growth on the PEM but to a different degree depending on the testing method. This result demonstrates the need for defining proper method to evaluate antibacterial properties of surface coatings.Djanklich LeylaAndreeva TonyaXiong XinKrastev RumenKemkemer RalfDe Gruyterarticlepolyelectrolyte multilayer coatingsimplantsantibacterial coatingnorm testsMedicineRENCurrent Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 473-476 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	polyelectrolyte multilayer coatings implants antibacterial coating norm tests Medicine R
spellingShingle	polyelectrolyte multilayer coatings implants antibacterial coating norm tests Medicine R Djanklich Leyla Andreeva Tonya Xiong Xin Krastev Rumen Kemkemer Ralf Evaluation of antibacterial properties of polyelectrolyte multilayer coatings by norm tests
description	Medical implants play a central role in modern medicine and both, naturally derived and synthetic materials have been explored as biomaterials for such devices. However, when implanted into living tissue, most materials initiate a host response. In addition, implants often cause bacterial infections leading to complications. Polyelectrolyte multilayer (PEM) coatings can be used for functionalization of medical implants improving the implant integration and reducing foreign body reactions. Some PEMs are also known to show antibacterial properties. We developed a PEM coating suggesting that it can decrease the risk of bacterial infections occurring after implantation while being highly biocompatible. We applied two different standard tests for evaluating the PEM’s antibacterial properties, the ISO norm (ISO 22196) and one ASTM norm (ASTM E2180) test. We found a reduction of bacterial growth on the PEM but to a different degree depending on the testing method. This result demonstrates the need for defining proper method to evaluate antibacterial properties of surface coatings.
format	article
author	Djanklich Leyla Andreeva Tonya Xiong Xin Krastev Rumen Kemkemer Ralf
author_facet	Djanklich Leyla Andreeva Tonya Xiong Xin Krastev Rumen Kemkemer Ralf
author_sort	Djanklich Leyla
title	Evaluation of antibacterial properties of polyelectrolyte multilayer coatings by norm tests
title_short	Evaluation of antibacterial properties of polyelectrolyte multilayer coatings by norm tests
title_full	Evaluation of antibacterial properties of polyelectrolyte multilayer coatings by norm tests
title_fullStr	Evaluation of antibacterial properties of polyelectrolyte multilayer coatings by norm tests
title_full_unstemmed	Evaluation of antibacterial properties of polyelectrolyte multilayer coatings by norm tests
title_sort	evaluation of antibacterial properties of polyelectrolyte multilayer coatings by norm tests
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/7a0bff703c4e40ae873384646b8d4bcb
work_keys_str_mv	AT djanklichleyla evaluationofantibacterialpropertiesofpolyelectrolytemultilayercoatingsbynormtests AT andreevatonya evaluationofantibacterialpropertiesofpolyelectrolytemultilayercoatingsbynormtests AT xiongxin evaluationofantibacterialpropertiesofpolyelectrolytemultilayercoatingsbynormtests AT krastevrumen evaluationofantibacterialpropertiesofpolyelectrolytemultilayercoatingsbynormtests AT kemkemerralf evaluationofantibacterialpropertiesofpolyelectrolytemultilayercoatingsbynormtests
_version_	1718371793636425728

Evaluation of antibacterial properties of polyelectrolyte multilayer coatings by norm tests

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