Distribution and development of peripheral glial cells in the human fetal cochlea.

The adult human cochlea contains various types of peripheral glial cells that envelop or myelinate the three different domains of the spiral ganglion neurons: the central processes in the cochlear nerve, the cell bodies in the spiral ganglia, and the peripheral processes in the osseous spiral lamina...

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Autores principales:	Heiko Locher, John C M J de Groot, Liesbeth van Iperen, Margriet A Huisman, Johan H M Frijns, Susana M Chuva de Sousa Lopes
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7a10cec3dbd9477688b415b4cae26395
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spelling	oai:doaj.org-article:7a10cec3dbd9477688b415b4cae263952021-11-18T08:34:23ZDistribution and development of peripheral glial cells in the human fetal cochlea.1932-620310.1371/journal.pone.0088066https://doaj.org/article/7a10cec3dbd9477688b415b4cae263952014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24498246/?tool=EBIhttps://doaj.org/toc/1932-6203The adult human cochlea contains various types of peripheral glial cells that envelop or myelinate the three different domains of the spiral ganglion neurons: the central processes in the cochlear nerve, the cell bodies in the spiral ganglia, and the peripheral processes in the osseous spiral lamina. Little is known about the distribution, lineage separation and maturation of these peripheral glial cells in the human fetal cochlea. In the current study, we observed peripheral glial cells expressing SOX10, SOX9 and S100B as early as 9 weeks of gestation (W9) in all three neuronal domains. We propose that these cells are the common precursor to both mature Schwann cells and satellite glial cells. Additionally, the peripheral glial cells located along the peripheral processes expressed NGFR, indicating a phenotype distinct from the peripheral glial cells located along the central processes. From W12, the spiral ganglion was gradually populated by satellite glial cells in a spatiotemporal gradient. In the cochlear nerve, radial sorting was accomplished by W22 and myelination started prior to myelination of the peripheral processes. The developmental dynamics of the peripheral glial cells in the human fetal cochlea is in support of a neural crest origin. Our study provides the first overview of the distribution and maturation of peripheral glial cells in the human fetal cochlea from W9 to W22.Heiko LocherJohn C M J de GrootLiesbeth van IperenMargriet A HuismanJohan H M FrijnsSusana M Chuva de Sousa LopesPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 1, p e88066 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Heiko Locher John C M J de Groot Liesbeth van Iperen Margriet A Huisman Johan H M Frijns Susana M Chuva de Sousa Lopes Distribution and development of peripheral glial cells in the human fetal cochlea.
description	The adult human cochlea contains various types of peripheral glial cells that envelop or myelinate the three different domains of the spiral ganglion neurons: the central processes in the cochlear nerve, the cell bodies in the spiral ganglia, and the peripheral processes in the osseous spiral lamina. Little is known about the distribution, lineage separation and maturation of these peripheral glial cells in the human fetal cochlea. In the current study, we observed peripheral glial cells expressing SOX10, SOX9 and S100B as early as 9 weeks of gestation (W9) in all three neuronal domains. We propose that these cells are the common precursor to both mature Schwann cells and satellite glial cells. Additionally, the peripheral glial cells located along the peripheral processes expressed NGFR, indicating a phenotype distinct from the peripheral glial cells located along the central processes. From W12, the spiral ganglion was gradually populated by satellite glial cells in a spatiotemporal gradient. In the cochlear nerve, radial sorting was accomplished by W22 and myelination started prior to myelination of the peripheral processes. The developmental dynamics of the peripheral glial cells in the human fetal cochlea is in support of a neural crest origin. Our study provides the first overview of the distribution and maturation of peripheral glial cells in the human fetal cochlea from W9 to W22.
format	article
author	Heiko Locher John C M J de Groot Liesbeth van Iperen Margriet A Huisman Johan H M Frijns Susana M Chuva de Sousa Lopes
author_facet	Heiko Locher John C M J de Groot Liesbeth van Iperen Margriet A Huisman Johan H M Frijns Susana M Chuva de Sousa Lopes
author_sort	Heiko Locher
title	Distribution and development of peripheral glial cells in the human fetal cochlea.
title_short	Distribution and development of peripheral glial cells in the human fetal cochlea.
title_full	Distribution and development of peripheral glial cells in the human fetal cochlea.
title_fullStr	Distribution and development of peripheral glial cells in the human fetal cochlea.
title_full_unstemmed	Distribution and development of peripheral glial cells in the human fetal cochlea.
title_sort	distribution and development of peripheral glial cells in the human fetal cochlea.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/7a10cec3dbd9477688b415b4cae26395
work_keys_str_mv	AT heikolocher distributionanddevelopmentofperipheralglialcellsinthehumanfetalcochlea AT johncmjdegroot distributionanddevelopmentofperipheralglialcellsinthehumanfetalcochlea AT liesbethvaniperen distributionanddevelopmentofperipheralglialcellsinthehumanfetalcochlea AT margrietahuisman distributionanddevelopmentofperipheralglialcellsinthehumanfetalcochlea AT johanhmfrijns distributionanddevelopmentofperipheralglialcellsinthehumanfetalcochlea AT susanamchuvadesousalopes distributionanddevelopmentofperipheralglialcellsinthehumanfetalcochlea
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Distribution and development of peripheral glial cells in the human fetal cochlea.

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