Biocompatibility and patency of a novel titanium vascular anastomotic device in a pig jugular vein

Abstract This study aimed to evaluate the biocompatibility and patency of our newly developed titanium vascular anastomotic device (TVAD) in a pig jugular vein. TVAD was made of commercially pure grade 2 titanium. The patency and anastomotic time were simultaneously confirmed in an ex-vivo system de...

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Autores principales:	Sanghyun An, Junsik Kim, Donghyun Lee, Minwoo Kim, Kangil Byun, Jangkyu Yun, Woonhyeok Jeong, Daegu Son
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7a1213c2e77148e39dc7a31ae6ee7135
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spelling	oai:doaj.org-article:7a1213c2e77148e39dc7a31ae6ee71352021-12-02T17:51:21ZBiocompatibility and patency of a novel titanium vascular anastomotic device in a pig jugular vein10.1038/s41598-021-97157-y2045-2322https://doaj.org/article/7a1213c2e77148e39dc7a31ae6ee71352021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97157-yhttps://doaj.org/toc/2045-2322Abstract This study aimed to evaluate the biocompatibility and patency of our newly developed titanium vascular anastomotic device (TVAD) in a pig jugular vein. TVAD was made of commercially pure grade 2 titanium. The patency and anastomotic time were simultaneously confirmed in an ex-vivo system developed by the authors and in vivo using pig jugular veins. Five 8-month-old pigs, with body weights of 50–60 kg, underwent anastomosis of both jugular veins using the device. Graft patency was evaluated for 12 weeks by biplane angiography and sonography. All tissue biopsy samples were analysed by histology. In all 10 cases, the anastomosis was completed in < 5 min. The vessel lumen was not damaged, and the inner vessel wall was completely endothelialised at the anastomotic site. No foreign body reactions were observed at the vessel lumen, vessels, and outer vessel walls by histopathologic analysis. Patency and absence of leakage at the anastomotic site of the follow-up period were confirmed clearly by angiography and sonography. This preliminary animal study proved that our newly developed device is a very promising tool for intima-to-intima contact anastomosis. TVAD can be used as a feasible and safe medical tool for vessel anastomosis.Sanghyun AnJunsik KimDonghyun LeeMinwoo KimKangil ByunJangkyu YunWoonhyeok JeongDaegu SonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sanghyun An Junsik Kim Donghyun Lee Minwoo Kim Kangil Byun Jangkyu Yun Woonhyeok Jeong Daegu Son Biocompatibility and patency of a novel titanium vascular anastomotic device in a pig jugular vein
description	Abstract This study aimed to evaluate the biocompatibility and patency of our newly developed titanium vascular anastomotic device (TVAD) in a pig jugular vein. TVAD was made of commercially pure grade 2 titanium. The patency and anastomotic time were simultaneously confirmed in an ex-vivo system developed by the authors and in vivo using pig jugular veins. Five 8-month-old pigs, with body weights of 50–60 kg, underwent anastomosis of both jugular veins using the device. Graft patency was evaluated for 12 weeks by biplane angiography and sonography. All tissue biopsy samples were analysed by histology. In all 10 cases, the anastomosis was completed in < 5 min. The vessel lumen was not damaged, and the inner vessel wall was completely endothelialised at the anastomotic site. No foreign body reactions were observed at the vessel lumen, vessels, and outer vessel walls by histopathologic analysis. Patency and absence of leakage at the anastomotic site of the follow-up period were confirmed clearly by angiography and sonography. This preliminary animal study proved that our newly developed device is a very promising tool for intima-to-intima contact anastomosis. TVAD can be used as a feasible and safe medical tool for vessel anastomosis.
format	article
author	Sanghyun An Junsik Kim Donghyun Lee Minwoo Kim Kangil Byun Jangkyu Yun Woonhyeok Jeong Daegu Son
author_facet	Sanghyun An Junsik Kim Donghyun Lee Minwoo Kim Kangil Byun Jangkyu Yun Woonhyeok Jeong Daegu Son
author_sort	Sanghyun An
title	Biocompatibility and patency of a novel titanium vascular anastomotic device in a pig jugular vein
title_short	Biocompatibility and patency of a novel titanium vascular anastomotic device in a pig jugular vein
title_full	Biocompatibility and patency of a novel titanium vascular anastomotic device in a pig jugular vein
title_fullStr	Biocompatibility and patency of a novel titanium vascular anastomotic device in a pig jugular vein
title_full_unstemmed	Biocompatibility and patency of a novel titanium vascular anastomotic device in a pig jugular vein
title_sort	biocompatibility and patency of a novel titanium vascular anastomotic device in a pig jugular vein
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7a1213c2e77148e39dc7a31ae6ee7135
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Biocompatibility and patency of a novel titanium vascular anastomotic device in a pig jugular vein

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