Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure

Abstract Micro-optical coherence tomography (µOCT) is a novel imaging approach enabling visualization of the microstructures of biological tissues at a cellular or sub-cellular level. However, it has been challenging to develop a miniaturized flexible endoscopic µOCT probe allowing helical luminal s...

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Autores principales:	Junyoung Kim, Sunwon Kim, Joon Woo Song, Hyun Jung Kim, Min Woo Lee, Jeongmoo Han, Jin Won Kim, Hongki Yoo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7a12aed0afd541df94bea539dcbb7452
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spelling	oai:doaj.org-article:7a12aed0afd541df94bea539dcbb74522021-12-02T17:52:33ZFlexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure10.1038/s41598-020-65742-22045-2322https://doaj.org/article/7a12aed0afd541df94bea539dcbb74522020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-65742-2https://doaj.org/toc/2045-2322Abstract Micro-optical coherence tomography (µOCT) is a novel imaging approach enabling visualization of the microstructures of biological tissues at a cellular or sub-cellular level. However, it has been challenging to develop a miniaturized flexible endoscopic µOCT probe allowing helical luminal scanning. In this study, we built a flexible endoscopic µOCT probe with an outer diameter of 1.2 mm, which acquires three-dimensional images of the arterial microstructures via helical scanning with an axial and lateral resolutions of 1.83 µm and 3.38 µm in air, respectively. Furthermore, the depth of focus of the µOCT imaging probe was extended two-fold using a binary phase spatial filter. We demonstrated that the present endoscopic µOCT could image cellular level features of a rabbit artery with high-risk atheroma and a bioresorbable scaffold-implanted swine coronary artery. This highly-translatable endoscopic µOCT will be a useful tool for investigating coronary artery disease and stent biology.Junyoung KimSunwon KimJoon Woo SongHyun Jung KimMin Woo LeeJeongmoo HanJin Won KimHongki YooNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Junyoung Kim Sunwon Kim Joon Woo Song Hyun Jung Kim Min Woo Lee Jeongmoo Han Jin Won Kim Hongki Yoo Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure
description	Abstract Micro-optical coherence tomography (µOCT) is a novel imaging approach enabling visualization of the microstructures of biological tissues at a cellular or sub-cellular level. However, it has been challenging to develop a miniaturized flexible endoscopic µOCT probe allowing helical luminal scanning. In this study, we built a flexible endoscopic µOCT probe with an outer diameter of 1.2 mm, which acquires three-dimensional images of the arterial microstructures via helical scanning with an axial and lateral resolutions of 1.83 µm and 3.38 µm in air, respectively. Furthermore, the depth of focus of the µOCT imaging probe was extended two-fold using a binary phase spatial filter. We demonstrated that the present endoscopic µOCT could image cellular level features of a rabbit artery with high-risk atheroma and a bioresorbable scaffold-implanted swine coronary artery. This highly-translatable endoscopic µOCT will be a useful tool for investigating coronary artery disease and stent biology.
format	article
author	Junyoung Kim Sunwon Kim Joon Woo Song Hyun Jung Kim Min Woo Lee Jeongmoo Han Jin Won Kim Hongki Yoo
author_facet	Junyoung Kim Sunwon Kim Joon Woo Song Hyun Jung Kim Min Woo Lee Jeongmoo Han Jin Won Kim Hongki Yoo
author_sort	Junyoung Kim
title	Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure
title_short	Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure
title_full	Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure
title_fullStr	Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure
title_full_unstemmed	Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure
title_sort	flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/7a12aed0afd541df94bea539dcbb7452
work_keys_str_mv	AT junyoungkim flexibleendoscopicmicroopticalcoherencetomographyforthreedimensionalimagingofthearterialmicrostructure AT sunwonkim flexibleendoscopicmicroopticalcoherencetomographyforthreedimensionalimagingofthearterialmicrostructure AT joonwoosong flexibleendoscopicmicroopticalcoherencetomographyforthreedimensionalimagingofthearterialmicrostructure AT hyunjungkim flexibleendoscopicmicroopticalcoherencetomographyforthreedimensionalimagingofthearterialmicrostructure AT minwoolee flexibleendoscopicmicroopticalcoherencetomographyforthreedimensionalimagingofthearterialmicrostructure AT jeongmoohan flexibleendoscopicmicroopticalcoherencetomographyforthreedimensionalimagingofthearterialmicrostructure AT jinwonkim flexibleendoscopicmicroopticalcoherencetomographyforthreedimensionalimagingofthearterialmicrostructure AT hongkiyoo flexibleendoscopicmicroopticalcoherencetomographyforthreedimensionalimagingofthearterialmicrostructure
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Flexible endoscopic micro-optical coherence tomography for three-dimensional imaging of the arterial microstructure

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