Resting heart rate is associated with colorectal advanced adenoma.

<h4>Background and aims</h4>Resting heart rate is an independent predictor of colorectal cancer (CRC) development and CRC-related mortality. However, little is known about the relationship between resting heart rate and colorectal adenoma development. We aimed to investigate this associa...

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Autores principales:	Jihye Park, Jong Soo Han, Hyun Jin Jo, Hyun Young Kim, Hyuk Yoon, Cheol Min Shin, Young Soo Park, Nayoung Kim, Dong Ho Lee
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7a12e8861093421a8e9b996693ff6bd3
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spelling	oai:doaj.org-article:7a12e8861093421a8e9b996693ff6bd32021-12-02T20:15:31ZResting heart rate is associated with colorectal advanced adenoma.1932-620310.1371/journal.pone.0254505https://doaj.org/article/7a12e8861093421a8e9b996693ff6bd32021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0254505https://doaj.org/toc/1932-6203<h4>Background and aims</h4>Resting heart rate is an independent predictor of colorectal cancer (CRC) development and CRC-related mortality. However, little is known about the relationship between resting heart rate and colorectal adenoma development. We aimed to investigate this association in a population who underwent screening colonoscopy.<h4>Methods</h4>Among 39,021 patients who underwent both electrocardiogram and screening colonoscopy during routine health examinations at the Seoul National University Bundang Hospital, Health Promotion Center, Korea from January 2014 to July 2019, 1,344 patients had advanced adenoma. We performed 1:1 propensity score (PS) matching to establish a control group that mitigated the confounding effects of age and sex. We performed multivariate logistic regression analyses to identify the independent risk factors of advanced adenoma development.<h4>Results</h4>Resting heart rate was significantly higher in the advanced adenoma group than in the control group. The prevalence of advanced polyp increased across the quartiles of resting heart rate. Patients with higher resting heart rates were more likely to be older, smokers, and have increased blood pressure and DM and less likely to engage in active exercises than those with lower resting heart rates. Patients with higher resting heart rates had higher serum glucose, triglyceride, hemoglobin A1C, and insulin levels and lower high-density lipoprotein cholesterol levels. Patients with resting heart rate in the highest quartile (≥71 bpm) still showed significantly increased odds ratio (OR) of advanced adenoma development (OR: 1.379, 95% confidence interval: 1.099-1.731, p = 0.006).<h4>Conclusions</h4>High resting heart rate was a meaningful independent risk factor of advanced adenoma development.Jihye ParkJong Soo HanHyun Jin JoHyun Young KimHyuk YoonCheol Min ShinYoung Soo ParkNayoung KimDong Ho LeePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 7, p e0254505 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jihye Park Jong Soo Han Hyun Jin Jo Hyun Young Kim Hyuk Yoon Cheol Min Shin Young Soo Park Nayoung Kim Dong Ho Lee Resting heart rate is associated with colorectal advanced adenoma.
description	<h4>Background and aims</h4>Resting heart rate is an independent predictor of colorectal cancer (CRC) development and CRC-related mortality. However, little is known about the relationship between resting heart rate and colorectal adenoma development. We aimed to investigate this association in a population who underwent screening colonoscopy.<h4>Methods</h4>Among 39,021 patients who underwent both electrocardiogram and screening colonoscopy during routine health examinations at the Seoul National University Bundang Hospital, Health Promotion Center, Korea from January 2014 to July 2019, 1,344 patients had advanced adenoma. We performed 1:1 propensity score (PS) matching to establish a control group that mitigated the confounding effects of age and sex. We performed multivariate logistic regression analyses to identify the independent risk factors of advanced adenoma development.<h4>Results</h4>Resting heart rate was significantly higher in the advanced adenoma group than in the control group. The prevalence of advanced polyp increased across the quartiles of resting heart rate. Patients with higher resting heart rates were more likely to be older, smokers, and have increased blood pressure and DM and less likely to engage in active exercises than those with lower resting heart rates. Patients with higher resting heart rates had higher serum glucose, triglyceride, hemoglobin A1C, and insulin levels and lower high-density lipoprotein cholesterol levels. Patients with resting heart rate in the highest quartile (≥71 bpm) still showed significantly increased odds ratio (OR) of advanced adenoma development (OR: 1.379, 95% confidence interval: 1.099-1.731, p = 0.006).<h4>Conclusions</h4>High resting heart rate was a meaningful independent risk factor of advanced adenoma development.
format	article
author	Jihye Park Jong Soo Han Hyun Jin Jo Hyun Young Kim Hyuk Yoon Cheol Min Shin Young Soo Park Nayoung Kim Dong Ho Lee
author_facet	Jihye Park Jong Soo Han Hyun Jin Jo Hyun Young Kim Hyuk Yoon Cheol Min Shin Young Soo Park Nayoung Kim Dong Ho Lee
author_sort	Jihye Park
title	Resting heart rate is associated with colorectal advanced adenoma.
title_short	Resting heart rate is associated with colorectal advanced adenoma.
title_full	Resting heart rate is associated with colorectal advanced adenoma.
title_fullStr	Resting heart rate is associated with colorectal advanced adenoma.
title_full_unstemmed	Resting heart rate is associated with colorectal advanced adenoma.
title_sort	resting heart rate is associated with colorectal advanced adenoma.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/7a12e8861093421a8e9b996693ff6bd3
work_keys_str_mv	AT jihyepark restingheartrateisassociatedwithcolorectaladvancedadenoma AT jongsoohan restingheartrateisassociatedwithcolorectaladvancedadenoma AT hyunjinjo restingheartrateisassociatedwithcolorectaladvancedadenoma AT hyunyoungkim restingheartrateisassociatedwithcolorectaladvancedadenoma AT hyukyoon restingheartrateisassociatedwithcolorectaladvancedadenoma AT cheolminshin restingheartrateisassociatedwithcolorectaladvancedadenoma AT youngsoopark restingheartrateisassociatedwithcolorectaladvancedadenoma AT nayoungkim restingheartrateisassociatedwithcolorectaladvancedadenoma AT dongholee restingheartrateisassociatedwithcolorectaladvancedadenoma
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Resting heart rate is associated with colorectal advanced adenoma.

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