Relationship between TNF-α levels and psychiatric symptoms in first-episode drug-naïve patients with schizophrenia before and after risperidone treatment and in chronic patients
Abstract Background The influence of antipsychotic drugs on tumor necrosis factor-α (TNF-α) levels is unclear, and there is no consensus on the association between TNF-α and psychotic symptoms. This study aimed to investigate the differences in TNF-α levels and clinical correlations in first-episode...
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2021
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oai:doaj.org-article:7a13573320e4432f80c63e095b47d2202021-11-14T12:08:32ZRelationship between TNF-α levels and psychiatric symptoms in first-episode drug-naïve patients with schizophrenia before and after risperidone treatment and in chronic patients10.1186/s12888-021-03569-51471-244Xhttps://doaj.org/article/7a13573320e4432f80c63e095b47d2202021-11-01T00:00:00Zhttps://doi.org/10.1186/s12888-021-03569-5https://doaj.org/toc/1471-244XAbstract Background The influence of antipsychotic drugs on tumor necrosis factor-α (TNF-α) levels is unclear, and there is no consensus on the association between TNF-α and psychotic symptoms. This study aimed to investigate the differences in TNF-α levels and clinical correlations in first-episode drug-naïve (FEDN) patients with schizophrenia before and after treatment and in chronic patients. Methods A total of 103 (51 FEDN and 52 chronic) patients and 114 healthy controls were recruited. Demographic and clinical data, including TNF-α levels, were recorded. We used the Positive and Negative Syndrome Scale (PANSS) to measure the psychopathology of all patients. Results TNF-α levels before treatment were significantly higher in FEDN patients than in chronic patients and healthy controls. No significant sex differences were found in the TNF-α levels of patients with schizophrenia. The TNF-α levels before treatment were significantly positively related to changes in PANSS negative symptoms in FEDN patients. The TNF-α levels in chronic patients were significantly negatively correlated with the general psychopathology subscales and PANSS total scores. Conclusions Increased TNF-α levels in FEDN patients and their correlation with psychopathology indicate that inflammatory cytokines may play a crucial role in the etiopathogenesis of schizophrenia, and inflammation-directed therapy may, therefore, improve negative symptoms.Chen LinKe ChenJianjin YuWei FengWeihong FuFude YangXiangyang ZhangDachun ChenBMCarticleSchizophreniaTNF-αInflammatory cytokinesPANSSPsychiatryRC435-571ENBMC Psychiatry, Vol 21, Iss 1, Pp 1-9 (2021) |
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DOAJ |
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DOAJ |
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EN |
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Schizophrenia TNF-α Inflammatory cytokines PANSS Psychiatry RC435-571 |
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Schizophrenia TNF-α Inflammatory cytokines PANSS Psychiatry RC435-571 Chen Lin Ke Chen Jianjin Yu Wei Feng Weihong Fu Fude Yang Xiangyang Zhang Dachun Chen Relationship between TNF-α levels and psychiatric symptoms in first-episode drug-naïve patients with schizophrenia before and after risperidone treatment and in chronic patients |
| description |
Abstract Background The influence of antipsychotic drugs on tumor necrosis factor-α (TNF-α) levels is unclear, and there is no consensus on the association between TNF-α and psychotic symptoms. This study aimed to investigate the differences in TNF-α levels and clinical correlations in first-episode drug-naïve (FEDN) patients with schizophrenia before and after treatment and in chronic patients. Methods A total of 103 (51 FEDN and 52 chronic) patients and 114 healthy controls were recruited. Demographic and clinical data, including TNF-α levels, were recorded. We used the Positive and Negative Syndrome Scale (PANSS) to measure the psychopathology of all patients. Results TNF-α levels before treatment were significantly higher in FEDN patients than in chronic patients and healthy controls. No significant sex differences were found in the TNF-α levels of patients with schizophrenia. The TNF-α levels before treatment were significantly positively related to changes in PANSS negative symptoms in FEDN patients. The TNF-α levels in chronic patients were significantly negatively correlated with the general psychopathology subscales and PANSS total scores. Conclusions Increased TNF-α levels in FEDN patients and their correlation with psychopathology indicate that inflammatory cytokines may play a crucial role in the etiopathogenesis of schizophrenia, and inflammation-directed therapy may, therefore, improve negative symptoms. |
| format |
article |
| author |
Chen Lin Ke Chen Jianjin Yu Wei Feng Weihong Fu Fude Yang Xiangyang Zhang Dachun Chen |
| author_facet |
Chen Lin Ke Chen Jianjin Yu Wei Feng Weihong Fu Fude Yang Xiangyang Zhang Dachun Chen |
| author_sort |
Chen Lin |
| title |
Relationship between TNF-α levels and psychiatric symptoms in first-episode drug-naïve patients with schizophrenia before and after risperidone treatment and in chronic patients |
| title_short |
Relationship between TNF-α levels and psychiatric symptoms in first-episode drug-naïve patients with schizophrenia before and after risperidone treatment and in chronic patients |
| title_full |
Relationship between TNF-α levels and psychiatric symptoms in first-episode drug-naïve patients with schizophrenia before and after risperidone treatment and in chronic patients |
| title_fullStr |
Relationship between TNF-α levels and psychiatric symptoms in first-episode drug-naïve patients with schizophrenia before and after risperidone treatment and in chronic patients |
| title_full_unstemmed |
Relationship between TNF-α levels and psychiatric symptoms in first-episode drug-naïve patients with schizophrenia before and after risperidone treatment and in chronic patients |
| title_sort |
relationship between tnf-α levels and psychiatric symptoms in first-episode drug-naïve patients with schizophrenia before and after risperidone treatment and in chronic patients |
| publisher |
BMC |
| publishDate |
2021 |
| url |
https://doaj.org/article/7a13573320e4432f80c63e095b47d220 |
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