Homeostatic Efficacy of Microporous Polysaccharide Hemosphere in Post-Operative Complications Reduction of Tubeless Percutaneous Nephrolithotomy

Introduction Current hemostatic agents are needed to reduce bleeding and transfusion during several surgery processes. Plant-based absorbable surgical hemostatic agents (microporous polysaccharide hemospheres) are proposed for use in surgical wound sites as an absorbable hemostat and in this study,...

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Autores principales:	Seyed Mohammad Kazem Aghamir, Mahdi Ramezani-binabaj, Fatemeh Khatami, Behrooz Fatahi
Formato:	article
Lenguaje:	EN
Publicado:	Urology Research Center 2020
Materias:	hemostatic agents percutaneous nephrolitotomy tubeless surgeries microporous polysaccharide hemospheres Diseases of the genitourinary system. Urology RC870-923
Acceso en línea:	https://doaj.org/article/7a15653f45d045fd8192bb1f99397dda
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spelling	oai:doaj.org-article:7a15653f45d045fd8192bb1f99397dda2021-11-29T07:35:05ZHomeostatic Efficacy of Microporous Polysaccharide Hemosphere in Post-Operative Complications Reduction of Tubeless Percutaneous Nephrolithotomy10.22034/TRU.2020.257231.10472717-042Xhttps://doaj.org/article/7a15653f45d045fd8192bb1f99397dda2020-08-01T00:00:00Zhttps://www.transresurology.com/article_119549.htmlhttps://doaj.org/toc/2717-042XIntroduction Current hemostatic agents are needed to reduce bleeding and transfusion during several surgery processes. Plant-based absorbable surgical hemostatic agents (microporous polysaccharide hemospheres) are proposed for use in surgical wound sites as an absorbable hemostat and in this study, we checked its efficacy. Methods This study was run under the Tehran University of Medical Science Ethics Committee observation based on the clinical trial registry criteria (IRCT20190624043991N1). Total numbers of 42 percutaneous nephrolithotomies (PCNL) patients were enrolled, 21 cases hemostatic powder and 21 controls. Hemostatic powder pumped into Amplatz sheath before its extraction. Results The mean age of the case and control groups was 42.1±19.5, and 42.1±18.5 years, respectively. The median stone size was 11.3±1.85cm. Overall, the differences between sex, age, stone size, and location were not statistically significant in the two groups (p-value˃0.05). Serum hemoglobin reduction following PCNL was significant in both groups compared to the serum level before surgery (p-value<0.001). However, the difference was not significant between case and control groups postoperatively (p-value=0.727). Yet, postoperative serum creatinine reduction was not significantly different between the two groups compared to preoperative serum levels (p-value>0.05). Conclusions The present study showed that microporous polysaccharide hemosphere (MPH) did not affect bleeding reduction, hemoglobin decline, and postoperative blood transfusion, and hospital stay.Seyed Mohammad Kazem Aghamir Mahdi Ramezani-binabaj Fatemeh Khatami Behrooz FatahiUrology Research Centerarticlehemostatic agentspercutaneous nephrolitotomytubeless surgeriesmicroporous polysaccharide hemospheresDiseases of the genitourinary system. UrologyRC870-923ENTranslational Research in Urology, Vol 2, Iss 3, Pp 83-88 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	hemostatic agents percutaneous nephrolitotomy tubeless surgeries microporous polysaccharide hemospheres Diseases of the genitourinary system. Urology RC870-923
spellingShingle	hemostatic agents percutaneous nephrolitotomy tubeless surgeries microporous polysaccharide hemospheres Diseases of the genitourinary system. Urology RC870-923 Seyed Mohammad Kazem Aghamir Mahdi Ramezani-binabaj Fatemeh Khatami Behrooz Fatahi Homeostatic Efficacy of Microporous Polysaccharide Hemosphere in Post-Operative Complications Reduction of Tubeless Percutaneous Nephrolithotomy
description	Introduction Current hemostatic agents are needed to reduce bleeding and transfusion during several surgery processes. Plant-based absorbable surgical hemostatic agents (microporous polysaccharide hemospheres) are proposed for use in surgical wound sites as an absorbable hemostat and in this study, we checked its efficacy. Methods This study was run under the Tehran University of Medical Science Ethics Committee observation based on the clinical trial registry criteria (IRCT20190624043991N1). Total numbers of 42 percutaneous nephrolithotomies (PCNL) patients were enrolled, 21 cases hemostatic powder and 21 controls. Hemostatic powder pumped into Amplatz sheath before its extraction. Results The mean age of the case and control groups was 42.1±19.5, and 42.1±18.5 years, respectively. The median stone size was 11.3±1.85cm. Overall, the differences between sex, age, stone size, and location were not statistically significant in the two groups (p-value˃0.05). Serum hemoglobin reduction following PCNL was significant in both groups compared to the serum level before surgery (p-value<0.001). However, the difference was not significant between case and control groups postoperatively (p-value=0.727). Yet, postoperative serum creatinine reduction was not significantly different between the two groups compared to preoperative serum levels (p-value>0.05). Conclusions The present study showed that microporous polysaccharide hemosphere (MPH) did not affect bleeding reduction, hemoglobin decline, and postoperative blood transfusion, and hospital stay.
format	article
author	Seyed Mohammad Kazem Aghamir Mahdi Ramezani-binabaj Fatemeh Khatami Behrooz Fatahi
author_facet	Seyed Mohammad Kazem Aghamir Mahdi Ramezani-binabaj Fatemeh Khatami Behrooz Fatahi
author_sort	Seyed Mohammad Kazem Aghamir
title	Homeostatic Efficacy of Microporous Polysaccharide Hemosphere in Post-Operative Complications Reduction of Tubeless Percutaneous Nephrolithotomy
title_short	Homeostatic Efficacy of Microporous Polysaccharide Hemosphere in Post-Operative Complications Reduction of Tubeless Percutaneous Nephrolithotomy
title_full	Homeostatic Efficacy of Microporous Polysaccharide Hemosphere in Post-Operative Complications Reduction of Tubeless Percutaneous Nephrolithotomy
title_fullStr	Homeostatic Efficacy of Microporous Polysaccharide Hemosphere in Post-Operative Complications Reduction of Tubeless Percutaneous Nephrolithotomy
title_full_unstemmed	Homeostatic Efficacy of Microporous Polysaccharide Hemosphere in Post-Operative Complications Reduction of Tubeless Percutaneous Nephrolithotomy
title_sort	homeostatic efficacy of microporous polysaccharide hemosphere in post-operative complications reduction of tubeless percutaneous nephrolithotomy
publisher	Urology Research Center
publishDate	2020
url	https://doaj.org/article/7a15653f45d045fd8192bb1f99397dda
work_keys_str_mv	AT seyedmohammadkazemaghamir homeostaticefficacyofmicroporouspolysaccharidehemosphereinpostoperativecomplicationsreductionoftubelesspercutaneousnephrolithotomy AT mahdiramezanibinabaj homeostaticefficacyofmicroporouspolysaccharidehemosphereinpostoperativecomplicationsreductionoftubelesspercutaneousnephrolithotomy AT fatemehkhatami homeostaticefficacyofmicroporouspolysaccharidehemosphereinpostoperativecomplicationsreductionoftubelesspercutaneousnephrolithotomy AT behroozfatahi homeostaticefficacyofmicroporouspolysaccharidehemosphereinpostoperativecomplicationsreductionoftubelesspercutaneousnephrolithotomy
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Homeostatic Efficacy of Microporous Polysaccharide Hemosphere in Post-Operative Complications Reduction of Tubeless Percutaneous Nephrolithotomy

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