Skin and immune cells crosstalk via circadian regulations

Both innate and adaptive immune cells exist in the skin, predominantly in the dermis layer. Recent studies have focused on how and which circadian rhythms contribute to maintain good health. Over recent years, we have gained a better understanding of the molecular mechanisms that control biological...

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Autor principal:	Kanami Orihara
Formato:	article
Lenguaje:	EN
Publicado:	Open Exploration Publishing Inc. 2021
Materias:	skin immune cells immunity chronobiology circadian rhythm body clock homeostasis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7a16a14a63b84c98babe4dd4585cc5c2
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spelling	oai:doaj.org-article:7a16a14a63b84c98babe4dd4585cc5c22021-11-24T06:43:19ZSkin and immune cells crosstalk via circadian regulations10.37349/ei.2021.000192768-6655https://doaj.org/article/7a16a14a63b84c98babe4dd4585cc5c22021-10-01T00:00:00Zhttps://www.explorationpub.com/Journals/ei/Article/100319https://doaj.org/toc/2768-6655Both innate and adaptive immune cells exist in the skin, predominantly in the dermis layer. Recent studies have focused on how and which circadian rhythms contribute to maintain good health. Over recent years, we have gained a better understanding of the molecular mechanisms that control biological clocks and circadian rhythms. Circadian rhythms maintain homeostasis by providing day and night information to various physiological functions of our body. However, excessively high immune system activity can lead to a risk of developing autoimmune or allergic diseases. Recently, increasing numbers of studies with human and mouse models have been conducted to investigate the mechanisms underlying circadian regulation of the skin homeostasis. In this review, circadian regulation in the skin will be discussed from different points of view. Skin is referred as the largest organ of the body and is directly exposed to the external environment, including large changes in diurnal temperature, light, and pathogens. Immune cells as well as skin cells are the ones protecting us from these stimulants. Associations of the circadian system and these cells have been revealed in many ways, however, the specific roles of the peripheral clocks in these cells remain unknown. Circadian regulation in the skin diseases is discussed specifically in atopic dermatitis and other skin allergic symptoms as well as psoriasis.Kanami OriharaOpen Exploration Publishing Inc.articleskinimmune cellsimmunitychronobiologycircadian rhythmbody clockhomeostasisImmunologic diseases. AllergyRC581-607ENExploration of Immunology, Vol 1, Iss 4, Pp 285-294 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	skin immune cells immunity chronobiology circadian rhythm body clock homeostasis Immunologic diseases. Allergy RC581-607
spellingShingle	skin immune cells immunity chronobiology circadian rhythm body clock homeostasis Immunologic diseases. Allergy RC581-607 Kanami Orihara Skin and immune cells crosstalk via circadian regulations
description	Both innate and adaptive immune cells exist in the skin, predominantly in the dermis layer. Recent studies have focused on how and which circadian rhythms contribute to maintain good health. Over recent years, we have gained a better understanding of the molecular mechanisms that control biological clocks and circadian rhythms. Circadian rhythms maintain homeostasis by providing day and night information to various physiological functions of our body. However, excessively high immune system activity can lead to a risk of developing autoimmune or allergic diseases. Recently, increasing numbers of studies with human and mouse models have been conducted to investigate the mechanisms underlying circadian regulation of the skin homeostasis. In this review, circadian regulation in the skin will be discussed from different points of view. Skin is referred as the largest organ of the body and is directly exposed to the external environment, including large changes in diurnal temperature, light, and pathogens. Immune cells as well as skin cells are the ones protecting us from these stimulants. Associations of the circadian system and these cells have been revealed in many ways, however, the specific roles of the peripheral clocks in these cells remain unknown. Circadian regulation in the skin diseases is discussed specifically in atopic dermatitis and other skin allergic symptoms as well as psoriasis.
format	article
author	Kanami Orihara
author_facet	Kanami Orihara
author_sort	Kanami Orihara
title	Skin and immune cells crosstalk via circadian regulations
title_short	Skin and immune cells crosstalk via circadian regulations
title_full	Skin and immune cells crosstalk via circadian regulations
title_fullStr	Skin and immune cells crosstalk via circadian regulations
title_full_unstemmed	Skin and immune cells crosstalk via circadian regulations
title_sort	skin and immune cells crosstalk via circadian regulations
publisher	Open Exploration Publishing Inc.
publishDate	2021
url	https://doaj.org/article/7a16a14a63b84c98babe4dd4585cc5c2
work_keys_str_mv	AT kanamiorihara skinandimmunecellscrosstalkviacircadianregulations
_version_	1718415920484843520

Skin and immune cells crosstalk via circadian regulations

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