Tumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study

Abstract Osteochondral destruction and a high recurrence rate after surgery are major concerns that make difficult the treatment course of tenosynovial giant cell tumor. The aims of this study were to elucidate rates of postoperative local recurrence and osteochondral destruction, as correlated with...

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Autores principales:	Takehiro Ota, Yoshihiro Nishida, Kunihiro Ikuta, Satoshi Tsukushi, Kenji Yamada, Eiji Kozawa, Hiroshi Urakawa, Shiro Imagama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/7a16e837ebf845fdb8c31a01e56af5db
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spelling	oai:doaj.org-article:7a16e837ebf845fdb8c31a01e56af5db2021-12-02T19:10:21ZTumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study10.1038/s41598-021-96795-62045-2322https://doaj.org/article/7a16e837ebf845fdb8c31a01e56af5db2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96795-6https://doaj.org/toc/2045-2322Abstract Osteochondral destruction and a high recurrence rate after surgery are major concerns that make difficult the treatment course of tenosynovial giant cell tumor. The aims of this study were to elucidate rates of postoperative local recurrence and osteochondral destruction, as correlated with various demographic factors. Eighty surgically treated patients with intra-articular tumors (knee: 49, ankle and foot: 12, hip: 10, others: 9) were included in this study. Factors including age, disease type (diffuse/localized), location, existence of osteochondral destruction were correlated with local recurrence or development/progression of osteochondral destruction. The 5-year local recurrence free survival rate was 71.4%. Diffuse type (n = 59, localized: n = 21) (P = 0.023) and knee location (P = 0.002) were independent risk factors for local recurrence. Diffuse type (P = 0.009) was a significant risk factor, and knee location (P = 0.001) was a negative factor for osteochondral destruction at the initial examination. Progression of osteochondral destruction was observed more often in cases with local recurrence (P = 0.040) and findings of osteochondral destruction at the initial examination (P = 0.029). Diffuse type is a factor that should be noted for both local recurrence and osteochondral destruction, while local recurrence occurs but osteochondral destruction is less observed in the knee.Takehiro OtaYoshihiro NishidaKunihiro IkutaSatoshi TsukushiKenji YamadaEiji KozawaHiroshi UrakawaShiro ImagamaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Takehiro Ota Yoshihiro Nishida Kunihiro Ikuta Satoshi Tsukushi Kenji Yamada Eiji Kozawa Hiroshi Urakawa Shiro Imagama Tumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study
description	Abstract Osteochondral destruction and a high recurrence rate after surgery are major concerns that make difficult the treatment course of tenosynovial giant cell tumor. The aims of this study were to elucidate rates of postoperative local recurrence and osteochondral destruction, as correlated with various demographic factors. Eighty surgically treated patients with intra-articular tumors (knee: 49, ankle and foot: 12, hip: 10, others: 9) were included in this study. Factors including age, disease type (diffuse/localized), location, existence of osteochondral destruction were correlated with local recurrence or development/progression of osteochondral destruction. The 5-year local recurrence free survival rate was 71.4%. Diffuse type (n = 59, localized: n = 21) (P = 0.023) and knee location (P = 0.002) were independent risk factors for local recurrence. Diffuse type (P = 0.009) was a significant risk factor, and knee location (P = 0.001) was a negative factor for osteochondral destruction at the initial examination. Progression of osteochondral destruction was observed more often in cases with local recurrence (P = 0.040) and findings of osteochondral destruction at the initial examination (P = 0.029). Diffuse type is a factor that should be noted for both local recurrence and osteochondral destruction, while local recurrence occurs but osteochondral destruction is less observed in the knee.
format	article
author	Takehiro Ota Yoshihiro Nishida Kunihiro Ikuta Satoshi Tsukushi Kenji Yamada Eiji Kozawa Hiroshi Urakawa Shiro Imagama
author_facet	Takehiro Ota Yoshihiro Nishida Kunihiro Ikuta Satoshi Tsukushi Kenji Yamada Eiji Kozawa Hiroshi Urakawa Shiro Imagama
author_sort	Takehiro Ota
title	Tumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study
title_short	Tumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study
title_full	Tumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study
title_fullStr	Tumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study
title_full_unstemmed	Tumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study
title_sort	tumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7a16e837ebf845fdb8c31a01e56af5db
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Tumor location and type affect local recurrence and joint damage in tenosynovial giant cell tumor: a multi-center study

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