Assessment and correction of the geriatric status of patients with metastatic colorectal cancer during the first-line systemic therapy
Humanity is rapidly aging, about 50% of all human malignancies develop in people over 65 years old. Cancer and antineoplastic therapy are potential pathophysiological stressors that worsen the course or intensify the development of previously compensated comorbidities and geriatric syndromes. At pre...
Guardado en:
| Autores principales: | , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | RU |
| Publicado: |
IP Habib O.N.
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/7a1b7f2238b942e5b7dd9118f1cb762b |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:7a1b7f2238b942e5b7dd9118f1cb762b |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:7a1b7f2238b942e5b7dd9118f1cb762b2021-11-30T16:55:01ZAssessment and correction of the geriatric status of patients with metastatic colorectal cancer during the first-line systemic therapy1815-14341815-144210.26442/18151434.2021.1.200754https://doaj.org/article/7a1b7f2238b942e5b7dd9118f1cb762b2021-05-01T00:00:00Zhttps://modernonco.orscience.ru/1815-1434/article/viewFile/70418/51350https://doaj.org/toc/1815-1434https://doaj.org/toc/1815-1442Humanity is rapidly aging, about 50% of all human malignancies develop in people over 65 years old. Cancer and antineoplastic therapy are potential pathophysiological stressors that worsen the course or intensify the development of previously compensated comorbidities and geriatric syndromes. At present, the role of assessment and correction of geriatric syndromes (CGS) for the purpose of effective first-line drug therapy in patients with metastatic CRC in the elderly and senile age, based on the use of a comprehensive geriatric assessment, has not been evaluated. Aim. Improving the efficiency of the first-line systemic antineoplastic treatment of patients with metastatic colorectal cancer in the elderly and senile age against the background of assessment and correction of the gerontological profile. Materials and methods. The study included data on 177 patients with metastatic colorectal cancer T1-4N1-2M1 (stage IV) who underwent first-line systemic therapy based on the FOLFOX-6 scheme at the Petrov National Medical Research Centre of Oncology from 2015 to 2021. The prospective group included 59 middle-aged and elderly patients who underwent assessment and CGS on the background of first-line systemic therapy. For analyzing the impact of assessment and CGS on the efficiency (objective response, disease control, event-free survival EFS) and the toxicity of systemic treatment, a retrospective review of the medical histories of 118 middle-aged and elderly patients who did not undergo assessment and CGS was performed. Results. Assessment and CGS allows to improve the results of patients with metastatic colorectal cancer, independently of age and treatment regimen: the toxicity is lower in the CGS group, neutropenia grade 3 was absent in the group with CGS, without CGS 10.7 and 14.8% for elderly and middle-aged, respectively; clinically significant response is also better in the group with CGS 87.8%; without CGS 69% (p0.05); the median EFS is 9.9 [8.8411.08] months in the group with CGS, and 7.2 [4.1510.24] months without CGS (p=0.02). Conclusion. In order to improve the efficiency of treatment of patients with metastatic colorectal cancer in the clinical practice of oncologists, it is advisable to conduct a comprehensive geriatric assessment and correction of geriatric syndromes.Yuliia V. AlekseevaTatiana Y. SemiglazovaSofiko M. SharashenidzeElena V. TkachenkoBoris S. KasparovNadezhda A. BrishGulfiia M. TeletaevaLarisa V. FilatovaMaksim I. SluzhevVladislav V. SemiglazovSvetlana A. ProtsenkoAleksei M. BelyaevIP Habib O.N.articlecolorectal cancercomprehensive geriatric assessmentcorrection of geriatric syndromesNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282RUСовременная онкология, Vol 23, Iss 1, Pp 133-140 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
RU |
| topic |
colorectal cancer comprehensive geriatric assessment correction of geriatric syndromes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
| spellingShingle |
colorectal cancer comprehensive geriatric assessment correction of geriatric syndromes Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Yuliia V. Alekseeva Tatiana Y. Semiglazova Sofiko M. Sharashenidze Elena V. Tkachenko Boris S. Kasparov Nadezhda A. Brish Gulfiia M. Teletaeva Larisa V. Filatova Maksim I. Sluzhev Vladislav V. Semiglazov Svetlana A. Protsenko Aleksei M. Belyaev Assessment and correction of the geriatric status of patients with metastatic colorectal cancer during the first-line systemic therapy |
| description |
Humanity is rapidly aging, about 50% of all human malignancies develop in people over 65 years old. Cancer and antineoplastic therapy are potential pathophysiological stressors that worsen the course or intensify the development of previously compensated comorbidities and geriatric syndromes. At present, the role of assessment and correction of geriatric syndromes (CGS) for the purpose of effective first-line drug therapy in patients with metastatic CRC in the elderly and senile age, based on the use of a comprehensive geriatric assessment, has not been evaluated.
Aim. Improving the efficiency of the first-line systemic antineoplastic treatment of patients with metastatic colorectal cancer in the elderly and senile age against the background of assessment and correction of the gerontological profile.
Materials and methods. The study included data on 177 patients with metastatic colorectal cancer T1-4N1-2M1 (stage IV) who underwent first-line systemic therapy based on the FOLFOX-6 scheme at the Petrov National Medical Research Centre of Oncology from 2015 to 2021. The prospective group included 59 middle-aged and elderly patients who underwent assessment and CGS on the background of first-line systemic therapy. For analyzing the impact of assessment and CGS on the efficiency (objective response, disease control, event-free survival EFS) and the toxicity of systemic treatment, a retrospective review of the medical histories of 118 middle-aged and elderly patients who did not undergo assessment and CGS was performed.
Results. Assessment and CGS allows to improve the results of patients with metastatic colorectal cancer, independently of age and treatment regimen: the toxicity is lower in the CGS group, neutropenia grade 3 was absent in the group with CGS, without CGS 10.7 and 14.8% for elderly and middle-aged, respectively; clinically significant response is also better in the group with CGS 87.8%; without CGS 69% (p0.05); the median EFS is 9.9 [8.8411.08] months in the group with CGS, and 7.2 [4.1510.24] months without CGS (p=0.02).
Conclusion. In order to improve the efficiency of treatment of patients with metastatic colorectal cancer in the clinical practice of oncologists, it is advisable to conduct a comprehensive geriatric assessment and correction of geriatric syndromes. |
| format |
article |
| author |
Yuliia V. Alekseeva Tatiana Y. Semiglazova Sofiko M. Sharashenidze Elena V. Tkachenko Boris S. Kasparov Nadezhda A. Brish Gulfiia M. Teletaeva Larisa V. Filatova Maksim I. Sluzhev Vladislav V. Semiglazov Svetlana A. Protsenko Aleksei M. Belyaev |
| author_facet |
Yuliia V. Alekseeva Tatiana Y. Semiglazova Sofiko M. Sharashenidze Elena V. Tkachenko Boris S. Kasparov Nadezhda A. Brish Gulfiia M. Teletaeva Larisa V. Filatova Maksim I. Sluzhev Vladislav V. Semiglazov Svetlana A. Protsenko Aleksei M. Belyaev |
| author_sort |
Yuliia V. Alekseeva |
| title |
Assessment and correction of the geriatric status of patients with metastatic colorectal cancer during the first-line systemic therapy |
| title_short |
Assessment and correction of the geriatric status of patients with metastatic colorectal cancer during the first-line systemic therapy |
| title_full |
Assessment and correction of the geriatric status of patients with metastatic colorectal cancer during the first-line systemic therapy |
| title_fullStr |
Assessment and correction of the geriatric status of patients with metastatic colorectal cancer during the first-line systemic therapy |
| title_full_unstemmed |
Assessment and correction of the geriatric status of patients with metastatic colorectal cancer during the first-line systemic therapy |
| title_sort |
assessment and correction of the geriatric status of patients with metastatic colorectal cancer during the first-line systemic therapy |
| publisher |
IP Habib O.N. |
| publishDate |
2021 |
| url |
https://doaj.org/article/7a1b7f2238b942e5b7dd9118f1cb762b |
| work_keys_str_mv |
AT yuliiavalekseeva assessmentandcorrectionofthegeriatricstatusofpatientswithmetastaticcolorectalcancerduringthefirstlinesystemictherapy AT tatianaysemiglazova assessmentandcorrectionofthegeriatricstatusofpatientswithmetastaticcolorectalcancerduringthefirstlinesystemictherapy AT sofikomsharashenidze assessmentandcorrectionofthegeriatricstatusofpatientswithmetastaticcolorectalcancerduringthefirstlinesystemictherapy AT elenavtkachenko assessmentandcorrectionofthegeriatricstatusofpatientswithmetastaticcolorectalcancerduringthefirstlinesystemictherapy AT borisskasparov assessmentandcorrectionofthegeriatricstatusofpatientswithmetastaticcolorectalcancerduringthefirstlinesystemictherapy AT nadezhdaabrish assessmentandcorrectionofthegeriatricstatusofpatientswithmetastaticcolorectalcancerduringthefirstlinesystemictherapy AT gulfiiamteletaeva assessmentandcorrectionofthegeriatricstatusofpatientswithmetastaticcolorectalcancerduringthefirstlinesystemictherapy AT larisavfilatova assessmentandcorrectionofthegeriatricstatusofpatientswithmetastaticcolorectalcancerduringthefirstlinesystemictherapy AT maksimisluzhev assessmentandcorrectionofthegeriatricstatusofpatientswithmetastaticcolorectalcancerduringthefirstlinesystemictherapy AT vladislavvsemiglazov assessmentandcorrectionofthegeriatricstatusofpatientswithmetastaticcolorectalcancerduringthefirstlinesystemictherapy AT svetlanaaprotsenko assessmentandcorrectionofthegeriatricstatusofpatientswithmetastaticcolorectalcancerduringthefirstlinesystemictherapy AT alekseimbelyaev assessmentandcorrectionofthegeriatricstatusofpatientswithmetastaticcolorectalcancerduringthefirstlinesystemictherapy |
| _version_ |
1718406452949811200 |