HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors

HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors

Nanog can confer resistance to cancer immunotherapy by promoting AKT activity. Here, the authors demonstrate that HSP90A is a Nanog target that stabilizes the AKT coactivator TCL1, thereby activating AKT, and that HSP90A inhibition can enhance the anti-tumor efficacy of adoptive T cell transfer and...

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Autores principales: Kwon-Ho Song, Se Jin Oh, Suyeon Kim, Hanbyoul Cho, Hyo-Jung Lee, Joon Seon Song, Joon-Yong Chung, Eunho Cho, Jaeyoon Lee, Seunghyun Jeon, Cassian Yee, Kyung-Mi Lee, Stephen M. Hewitt, Jae-Hoon Kim, Seon Rang Woo, Tae Woo Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/7a2282343e9345dc947552925cc53b27
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spelling oai:doaj.org-article:7a2282343e9345dc947552925cc53b272021-12-02T17:31:56ZHSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors10.1038/s41467-019-14259-y2041-1723https://doaj.org/article/7a2282343e9345dc947552925cc53b272020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14259-yhttps://doaj.org/toc/2041-1723Nanog can confer resistance to cancer immunotherapy by promoting AKT activity. Here, the authors demonstrate that HSP90A is a Nanog target that stabilizes the AKT coactivator TCL1, thereby activating AKT, and that HSP90A inhibition can enhance the anti-tumor efficacy of adoptive T cell transfer and checkpoint blockade.Kwon-Ho SongSe Jin OhSuyeon KimHanbyoul ChoHyo-Jung LeeJoon Seon SongJoon-Yong ChungEunho ChoJaeyoon LeeSeunghyun JeonCassian YeeKyung-Mi LeeStephen M. HewittJae-Hoon KimSeon Rang WooTae Woo KimNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kwon-Ho Song
Se Jin Oh
Suyeon Kim
Hanbyoul Cho
Hyo-Jung Lee
Joon Seon Song
Joon-Yong Chung
Eunho Cho
Jaeyoon Lee
Seunghyun Jeon
Cassian Yee
Kyung-Mi Lee
Stephen M. Hewitt
Jae-Hoon Kim
Seon Rang Woo
Tae Woo Kim
HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors
description Nanog can confer resistance to cancer immunotherapy by promoting AKT activity. Here, the authors demonstrate that HSP90A is a Nanog target that stabilizes the AKT coactivator TCL1, thereby activating AKT, and that HSP90A inhibition can enhance the anti-tumor efficacy of adoptive T cell transfer and checkpoint blockade.
format article
author Kwon-Ho Song
Se Jin Oh
Suyeon Kim
Hanbyoul Cho
Hyo-Jung Lee
Joon Seon Song
Joon-Yong Chung
Eunho Cho
Jaeyoon Lee
Seunghyun Jeon
Cassian Yee
Kyung-Mi Lee
Stephen M. Hewitt
Jae-Hoon Kim
Seon Rang Woo
Tae Woo Kim
author_facet Kwon-Ho Song
Se Jin Oh
Suyeon Kim
Hanbyoul Cho
Hyo-Jung Lee
Joon Seon Song
Joon-Yong Chung
Eunho Cho
Jaeyoon Lee
Seunghyun Jeon
Cassian Yee
Kyung-Mi Lee
Stephen M. Hewitt
Jae-Hoon Kim
Seon Rang Woo
Tae Woo Kim
author_sort Kwon-Ho Song
title HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors
title_short HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors
title_full HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors
title_fullStr HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors
title_full_unstemmed HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors
title_sort hsp90a inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/7a2282343e9345dc947552925cc53b27
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