HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors

HSP90A inhibition promotes anti-tumor immunity by reversing multi-modal resistance and stem-like property of immune-refractory tumors

Nanog can confer resistance to cancer immunotherapy by promoting AKT activity. Here, the authors demonstrate that HSP90A is a Nanog target that stabilizes the AKT coactivator TCL1, thereby activating AKT, and that HSP90A inhibition can enhance the anti-tumor efficacy of adoptive T cell transfer and...

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Autores principales: Kwon-Ho Song, Se Jin Oh, Suyeon Kim, Hanbyoul Cho, Hyo-Jung Lee, Joon Seon Song, Joon-Yong Chung, Eunho Cho, Jaeyoon Lee, Seunghyun Jeon, Cassian Yee, Kyung-Mi Lee, Stephen M. Hewitt, Jae-Hoon Kim, Seon Rang Woo, Tae Woo Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Science
Q
Acceso en línea:https://doaj.org/article/7a2282343e9345dc947552925cc53b27
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