CHANGES OF CYTOKINE PROFILE AND TRANSPORTER PROTEIN LEVELS IN PROLIFERATIVE DISORDERS OF UTERINE SYSTEM

Abstract. We studies blood sera of the women with verified endometriosis (End), cancer of ovaries (Can), cystadenoma (Cyst) and healthy women by similar age (Cont) for the contents of cytokines (TNFα, IL - 1β, IL-6, IFNγ), some macroglobulin proteins transporting them across cell walls, i.e., α2-mac...

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Autores principales:	V. N. Zorina, N. V. Promzeleva, T. V. Tretyakova, L. G. Bazhenova, T. G. Ryabicheva, S. V. Arkhipova, R. M. Zorina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	α2-macroglobulin ovarian cancer endometriosis cytokines acute phase proteins Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/7a262a753023483699dd43deb8171dc3
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spelling	oai:doaj.org-article:7a262a753023483699dd43deb8171dc32021-11-18T08:03:40ZCHANGES OF CYTOKINE PROFILE AND TRANSPORTER PROTEIN LEVELS IN PROLIFERATIVE DISORDERS OF UTERINE SYSTEM1563-06252313-741X10.15789/1563-0625-2009-2-3-185-190https://doaj.org/article/7a262a753023483699dd43deb8171dc32014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/290https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. We studies blood sera of the women with verified endometriosis (End), cancer of ovaries (Can), cystadenoma (Cyst) and healthy women by similar age (Cont) for the contents of cytokines (TNFα, IL - 1β, IL-6, IFNγ), some macroglobulin proteins transporting them across cell walls, i.e., α2-macroglobulin (α2 - Mg), and pregnancy-associated α2-glycoprotein (α2-PAG)), as well as some functional forms of α2 - Mg (α2-Mg-IgG and α2-Mg-plasmin complexes (α2-Mg-Pl), and intrinsic components of these complexes (total serum IgG and plasmin)), to establish their role in pathogenesis of abovementioned diseases. We have shown that the direction and expression of the changes are quite different. I.e., in ovarian cancer, the levels of α2 - PAG, α2-Mg-Pl, IL-6, and TNFα were considerably increased, concentrations of α2-Mg-IgG complex are moderately increased, but the contents of total IgG and IFNγ are not changed. Meanwhile, the levels of total α2-Mg and Pl are reduced. In cystadenoma, the total α2-Mg levels are significantly reduced, but total Pl and α2-PAG concentrations are constant, and only IL-1β and both type of complexes are significantly increased. Endometriosis is characterized by considerable increase of α2-PAG, IL-6, IL-1β and IgG serum levels, accompanied by relatively high concentrations of α2-Mg-IgG and α2-Mg-Pl complexes. To our mind, the changes revealed may represent either consequence, or a factor of an active neoplasm progression.V. N. ZorinaN. V. PromzelevaT. V. TretyakovaL. G. BazhenovaT. G. RyabichevaS. V. ArkhipovaR. M. ZorinaSPb RAACIarticleα2-macroglobulinovarian cancerendometriosiscytokinesacute phase proteinsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 2-3, Pp 185-190 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	α2-macroglobulin ovarian cancer endometriosis cytokines acute phase proteins Immunologic diseases. Allergy RC581-607
spellingShingle	α2-macroglobulin ovarian cancer endometriosis cytokines acute phase proteins Immunologic diseases. Allergy RC581-607 V. N. Zorina N. V. Promzeleva T. V. Tretyakova L. G. Bazhenova T. G. Ryabicheva S. V. Arkhipova R. M. Zorina CHANGES OF CYTOKINE PROFILE AND TRANSPORTER PROTEIN LEVELS IN PROLIFERATIVE DISORDERS OF UTERINE SYSTEM
description	Abstract. We studies blood sera of the women with verified endometriosis (End), cancer of ovaries (Can), cystadenoma (Cyst) and healthy women by similar age (Cont) for the contents of cytokines (TNFα, IL - 1β, IL-6, IFNγ), some macroglobulin proteins transporting them across cell walls, i.e., α2-macroglobulin (α2 - Mg), and pregnancy-associated α2-glycoprotein (α2-PAG)), as well as some functional forms of α2 - Mg (α2-Mg-IgG and α2-Mg-plasmin complexes (α2-Mg-Pl), and intrinsic components of these complexes (total serum IgG and plasmin)), to establish their role in pathogenesis of abovementioned diseases. We have shown that the direction and expression of the changes are quite different. I.e., in ovarian cancer, the levels of α2 - PAG, α2-Mg-Pl, IL-6, and TNFα were considerably increased, concentrations of α2-Mg-IgG complex are moderately increased, but the contents of total IgG and IFNγ are not changed. Meanwhile, the levels of total α2-Mg and Pl are reduced. In cystadenoma, the total α2-Mg levels are significantly reduced, but total Pl and α2-PAG concentrations are constant, and only IL-1β and both type of complexes are significantly increased. Endometriosis is characterized by considerable increase of α2-PAG, IL-6, IL-1β and IgG serum levels, accompanied by relatively high concentrations of α2-Mg-IgG and α2-Mg-Pl complexes. To our mind, the changes revealed may represent either consequence, or a factor of an active neoplasm progression.
format	article
author	V. N. Zorina N. V. Promzeleva T. V. Tretyakova L. G. Bazhenova T. G. Ryabicheva S. V. Arkhipova R. M. Zorina
author_facet	V. N. Zorina N. V. Promzeleva T. V. Tretyakova L. G. Bazhenova T. G. Ryabicheva S. V. Arkhipova R. M. Zorina
author_sort	V. N. Zorina
title	CHANGES OF CYTOKINE PROFILE AND TRANSPORTER PROTEIN LEVELS IN PROLIFERATIVE DISORDERS OF UTERINE SYSTEM
title_short	CHANGES OF CYTOKINE PROFILE AND TRANSPORTER PROTEIN LEVELS IN PROLIFERATIVE DISORDERS OF UTERINE SYSTEM
title_full	CHANGES OF CYTOKINE PROFILE AND TRANSPORTER PROTEIN LEVELS IN PROLIFERATIVE DISORDERS OF UTERINE SYSTEM
title_fullStr	CHANGES OF CYTOKINE PROFILE AND TRANSPORTER PROTEIN LEVELS IN PROLIFERATIVE DISORDERS OF UTERINE SYSTEM
title_full_unstemmed	CHANGES OF CYTOKINE PROFILE AND TRANSPORTER PROTEIN LEVELS IN PROLIFERATIVE DISORDERS OF UTERINE SYSTEM
title_sort	changes of cytokine profile and transporter protein levels in proliferative disorders of uterine system
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/7a262a753023483699dd43deb8171dc3
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_version_	1718422485455601664

CHANGES OF CYTOKINE PROFILE AND TRANSPORTER PROTEIN LEVELS IN PROLIFERATIVE DISORDERS OF UTERINE SYSTEM

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