Long-Term Beneficial Effects of Acupuncture with Reduced Risk of Depression Development Following Trigeminal Neuralgia: A Nationwide Population-Based Cohort Study

Chung-Chih Liao,1 Cheng-Li Lin,2,3 Ke-Ru Liao,4 Jung-Miao Li1,5 1Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan; 2Management Office for Health Data, China Medical University Hospital, Taichung 40447, Taiwan; 3College of Medicine,...

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Autores principales:	Liao CC, Lin CL, Liao KR, Li JM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	trigeminal neuralgia depression real-world data national health insurance research database acupuncture Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/7a269c9f54964067bda17e563ffaf90e
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spelling	oai:doaj.org-article:7a269c9f54964067bda17e563ffaf90e2021-12-02T15:16:28ZLong-Term Beneficial Effects of Acupuncture with Reduced Risk of Depression Development Following Trigeminal Neuralgia: A Nationwide Population-Based Cohort Study1178-2021https://doaj.org/article/7a269c9f54964067bda17e563ffaf90e2020-12-01T00:00:00Zhttps://www.dovepress.com/long-term-beneficial-effects-of-acupuncture-with-reduced-risk-of-depre-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Chung-Chih Liao,1 Cheng-Li Lin,2,3 Ke-Ru Liao,4 Jung-Miao Li1,5 1Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan; 2Management Office for Health Data, China Medical University Hospital, Taichung 40447, Taiwan; 3College of Medicine, China Medical University, Taichung 40402, Taiwan; 4Department of Neurology, Yuanlin Christian Hospital, Yuanlin 51052, Taiwan; 5Department of Chinese Medicine, Show Chwan Memorial Hospital, Changhua 50008, TaiwanCorrespondence: Ke-Ru Liao; Jung-Miao Li Email u9401407@cmu.edu.tw; rung-miau@hotmail.comBackground: Existing evidence has shown that patients with trigeminal neuralgia (TN) have a higher risk of developing depression than the normal population. Clinically, acupuncture has been widely used to alleviate pain in TN. However, few studies have explored the use of acupuncture to prevent depression in TN. Therefore, this study aimed to apply national real-world data to investigate the long-term effect of acupuncture on the risk of depression in patients with TN.Methods: We recruited participants with newly diagnosed TN from the Taiwanese National Health Insurance Research Database between January 1, 2000 and December 31, 2010, and categorized them into either the acupuncture cohort or non-acupuncture cohort using the 1:1 propensity score-matched method. All patients in the two cohorts were followed up until the end of 2013. Cox proportional hazards regression analysis was used to compare the incidence of depression between the two cohorts.Results: In total, 776 patients with newly diagnosed TN in each cohort with similar baseline characteristics were enrolled in the study. The acupuncture cohort had a reduced risk of depression compared to the non-acupuncture cohort (adjusted hazard ratio, 0.47; 95% confidence interval, 0.31– 0.70). Kaplan–Meier analysis also revealed that the cumulative incidence of depression was significantly lower in the acupuncture cohort during the 13-year follow-up period (Log rank test, p < 0.001). In particular, the beneficial effect of acupuncture was a decrease in the risk of depression among TN patients aged 50– 69 years who had also used carbamazepine.Conclusion: This study demonstrated that acupuncture is associated with a reduction in the risk of depression during long-term follow-up in patients with TN. The results provide new insights for clinical practitioners as well as for health resource allocation.Keywords: trigeminal neuralgia, depression, real-world data, National Health Insurance Research Database, acupunctureLiao CCLin CLLiao KRLi JMDove Medical Pressarticletrigeminal neuralgiadepressionreal-world datanational health insurance research databaseacupunctureNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 16, Pp 2961-2973 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	trigeminal neuralgia depression real-world data national health insurance research database acupuncture Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	trigeminal neuralgia depression real-world data national health insurance research database acupuncture Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Liao CC Lin CL Liao KR Li JM Long-Term Beneficial Effects of Acupuncture with Reduced Risk of Depression Development Following Trigeminal Neuralgia: A Nationwide Population-Based Cohort Study
description	Chung-Chih Liao,1 Cheng-Li Lin,2,3 Ke-Ru Liao,4 Jung-Miao Li1,5 1Graduate Institute of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan; 2Management Office for Health Data, China Medical University Hospital, Taichung 40447, Taiwan; 3College of Medicine, China Medical University, Taichung 40402, Taiwan; 4Department of Neurology, Yuanlin Christian Hospital, Yuanlin 51052, Taiwan; 5Department of Chinese Medicine, Show Chwan Memorial Hospital, Changhua 50008, TaiwanCorrespondence: Ke-Ru Liao; Jung-Miao Li Email u9401407@cmu.edu.tw; rung-miau@hotmail.comBackground: Existing evidence has shown that patients with trigeminal neuralgia (TN) have a higher risk of developing depression than the normal population. Clinically, acupuncture has been widely used to alleviate pain in TN. However, few studies have explored the use of acupuncture to prevent depression in TN. Therefore, this study aimed to apply national real-world data to investigate the long-term effect of acupuncture on the risk of depression in patients with TN.Methods: We recruited participants with newly diagnosed TN from the Taiwanese National Health Insurance Research Database between January 1, 2000 and December 31, 2010, and categorized them into either the acupuncture cohort or non-acupuncture cohort using the 1:1 propensity score-matched method. All patients in the two cohorts were followed up until the end of 2013. Cox proportional hazards regression analysis was used to compare the incidence of depression between the two cohorts.Results: In total, 776 patients with newly diagnosed TN in each cohort with similar baseline characteristics were enrolled in the study. The acupuncture cohort had a reduced risk of depression compared to the non-acupuncture cohort (adjusted hazard ratio, 0.47; 95% confidence interval, 0.31– 0.70). Kaplan–Meier analysis also revealed that the cumulative incidence of depression was significantly lower in the acupuncture cohort during the 13-year follow-up period (Log rank test, p < 0.001). In particular, the beneficial effect of acupuncture was a decrease in the risk of depression among TN patients aged 50– 69 years who had also used carbamazepine.Conclusion: This study demonstrated that acupuncture is associated with a reduction in the risk of depression during long-term follow-up in patients with TN. The results provide new insights for clinical practitioners as well as for health resource allocation.Keywords: trigeminal neuralgia, depression, real-world data, National Health Insurance Research Database, acupuncture
format	article
author	Liao CC Lin CL Liao KR Li JM
author_facet	Liao CC Lin CL Liao KR Li JM
author_sort	Liao CC
title	Long-Term Beneficial Effects of Acupuncture with Reduced Risk of Depression Development Following Trigeminal Neuralgia: A Nationwide Population-Based Cohort Study
title_short	Long-Term Beneficial Effects of Acupuncture with Reduced Risk of Depression Development Following Trigeminal Neuralgia: A Nationwide Population-Based Cohort Study
title_full	Long-Term Beneficial Effects of Acupuncture with Reduced Risk of Depression Development Following Trigeminal Neuralgia: A Nationwide Population-Based Cohort Study
title_fullStr	Long-Term Beneficial Effects of Acupuncture with Reduced Risk of Depression Development Following Trigeminal Neuralgia: A Nationwide Population-Based Cohort Study
title_full_unstemmed	Long-Term Beneficial Effects of Acupuncture with Reduced Risk of Depression Development Following Trigeminal Neuralgia: A Nationwide Population-Based Cohort Study
title_sort	long-term beneficial effects of acupuncture with reduced risk of depression development following trigeminal neuralgia: a nationwide population-based cohort study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/7a269c9f54964067bda17e563ffaf90e
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Long-Term Beneficial Effects of Acupuncture with Reduced Risk of Depression Development Following Trigeminal Neuralgia: A Nationwide Population-Based Cohort Study

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