Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair

How adhesive forces are transduced and integrated into biochemical signals at focal adhesions (FAs) is poorly understood. Here authors show that force- FAK signaling coupling coordinates cell migration and tissue-scale forces to promote microtissue repair.

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Autores principales:	Dennis W. Zhou, Marc A. Fernández-Yagüe, Elijah N. Holland, Andrés F. García, Nicolas S. Castro, Eric B. O’Neill, Jeroen Eyckmans, Christopher S. Chen, Jianping Fu, David D. Schlaepfer, Andrés J. García
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/7a26e4779fb9430c9f01584639edaf32
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spelling	oai:doaj.org-article:7a26e4779fb9430c9f01584639edaf322021-12-02T18:28:37ZForce-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair10.1038/s41467-021-22602-52041-1723https://doaj.org/article/7a26e4779fb9430c9f01584639edaf322021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22602-5https://doaj.org/toc/2041-1723How adhesive forces are transduced and integrated into biochemical signals at focal adhesions (FAs) is poorly understood. Here authors show that force- FAK signaling coupling coordinates cell migration and tissue-scale forces to promote microtissue repair.Dennis W. ZhouMarc A. Fernández-YagüeElijah N. HollandAndrés F. GarcíaNicolas S. CastroEric B. O’NeillJeroen EyckmansChristopher S. ChenJianping FuDavid D. SchlaepferAndrés J. GarcíaNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Dennis W. Zhou Marc A. Fernández-Yagüe Elijah N. Holland Andrés F. García Nicolas S. Castro Eric B. O’Neill Jeroen Eyckmans Christopher S. Chen Jianping Fu David D. Schlaepfer Andrés J. García Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair
description	How adhesive forces are transduced and integrated into biochemical signals at focal adhesions (FAs) is poorly understood. Here authors show that force- FAK signaling coupling coordinates cell migration and tissue-scale forces to promote microtissue repair.
format	article
author	Dennis W. Zhou Marc A. Fernández-Yagüe Elijah N. Holland Andrés F. García Nicolas S. Castro Eric B. O’Neill Jeroen Eyckmans Christopher S. Chen Jianping Fu David D. Schlaepfer Andrés J. García
author_facet	Dennis W. Zhou Marc A. Fernández-Yagüe Elijah N. Holland Andrés F. García Nicolas S. Castro Eric B. O’Neill Jeroen Eyckmans Christopher S. Chen Jianping Fu David D. Schlaepfer Andrés J. García
author_sort	Dennis W. Zhou
title	Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair
title_short	Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair
title_full	Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair
title_fullStr	Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair
title_full_unstemmed	Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair
title_sort	force-fak signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/7a26e4779fb9430c9f01584639edaf32
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Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair

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