Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair

Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair

How adhesive forces are transduced and integrated into biochemical signals at focal adhesions (FAs) is poorly understood. Here authors show that force- FAK signaling coupling coordinates cell migration and tissue-scale forces to promote microtissue repair.

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Autores principales: Dennis W. Zhou, Marc A. Fernández-Yagüe, Elijah N. Holland, Andrés F. García, Nicolas S. Castro, Eric B. O’Neill, Jeroen Eyckmans, Christopher S. Chen, Jianping Fu, David D. Schlaepfer, Andrés J. García
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
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Acceso en línea:https://doaj.org/article/7a26e4779fb9430c9f01584639edaf32
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