High efficiency closed-system gene transfer using automated spinoculation

High efficiency closed-system gene transfer using automated spinoculation

Abstract Background Gene transfer is an important tool for cellular therapies. Lentiviral vectors are most effectively transferred into lymphocytes or hematopoietic progenitor cells using spinoculation. To enable cGMP (current Good Manufacturing Practice)-compliant cell therapy production, we develo...

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Main Authors: Victoria Ann Remley, Jianjian Jin, Sarmila Sarkar, Larry Moses, Michaela Prochazkova, Yihua Cai, Lipei Shao, Hui Liu, Tatyana Fuksenko, Ping Jin, David F. Stroncek, Steven L. Highfill
Format: article
Language:EN
Published: BMC 2021
Subjects:
Sepax
Spinoculation
CAR T-cell
Gene transfer
Medicine
R
Online Access:https://doaj.org/article/7a27ea1b72e34fa48e8d324754b08462
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