Topical intraocular pressure therapy effects on pregnancy

Carmen Mendez-Hernandez, Julian Garcia-Feijoo, Federico Saenz-Frances, Enrique Santos-Bueso, Jose Maria Martinez-de-la-Casa, Alicia Valverde Megias, Ana M Fern&aacute;ndez-Vidal, Julian Garcia-SanchezOphthalmology Department, Hospital Clinico San Carlos de Madrid, Madrid, SpainPurpose: To as...

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Autores principales:	Mendez-Hernandez C, Garcia-Feijoo J, Saenz-Frances F, Santos-Bueso E, Martinez-de-la-Casa JM, Valverde Megias A, Fern&aacute;ndez-Vidal AM, Garcia-Sanchez J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/7a2e05875b42426aaa30053442c270d2
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spelling	oai:doaj.org-article:7a2e05875b42426aaa30053442c270d22021-12-02T07:56:50ZTopical intraocular pressure therapy effects on pregnancy1177-54671177-5483https://doaj.org/article/7a2e05875b42426aaa30053442c270d22012-10-01T00:00:00Zhttp://www.dovepress.com/topical-intraocular-pressure-therapy-effects-on-pregnancy-a11212https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Carmen Mendez-Hernandez, Julian Garcia-Feijoo, Federico Saenz-Frances, Enrique Santos-Bueso, Jose Maria Martinez-de-la-Casa, Alicia Valverde Megias, Ana M Fern&aacute;ndez-Vidal, Julian Garcia-SanchezOphthalmology Department, Hospital Clinico San Carlos de Madrid, Madrid, SpainPurpose: To assess the course of intraocular pressure (IOP), visual field progression, and adverse effects of antiglaucoma medication used during pregnancy.Methods: Thirteen eyes of eight patients with glaucoma were examined. Their clinical records were reviewed to compare IOP, number of medications, and visual field indices (VFI) before, during, and after pregnancy using a two-tailed paired t-test.Results: In seven (87.5%) of the eight patients, no disease progression was observed. IOP (mmHg) remained stable (baseline 17.3 &plusmn; 3.6; first trimester 17.4 &plusmn; 5.2, P = 0.930; second trimester 18.1 &plusmn; 4.7, P = 0.519; third trimester 20.2 &plusmn; 8.7, P = 0.344; and postpartum 21.5 &plusmn; 7.6, P = 0.136). The mean number of glaucoma treatments fell from 1.7 &plusmn; 0.52 before pregnancy to 0.83 &plusmn; 0.75 (P = 0.04) in the second and third trimesters. In one patient, IOP increased during pregnancy and there was further visual field loss. In the only patient kept on fixed combination timolol&ndash;dorzolamide therapy throughout pregnancy, labor was induced because of delayed intrauterine growth.Conclusions: No changes in IOP and VFI were detected in most patients despite a reduction in the number of hypotensive agents required. Delayed intrauterine growth in one patient under fixed combination timolol&ndash;dorzolamide treatment was observed whereas no other adverse effects were detected.Keywords: intraocular pressure, antiglaucoma medication, glaucoma, pregnancy, breast-feeding, adverse effectsMendez-Hernandez CGarcia-Feijoo JSaenz-Frances FSantos-Bueso EMartinez-de-la-Casa JMValverde Megias AFern&aacute;ndez-Vidal AMGarcia-Sanchez JDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2012, Iss default, Pp 1629-1632 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Mendez-Hernandez C Garcia-Feijoo J Saenz-Frances F Santos-Bueso E Martinez-de-la-Casa JM Valverde Megias A Fern&aacute;ndez-Vidal AM Garcia-Sanchez J Topical intraocular pressure therapy effects on pregnancy
description	Carmen Mendez-Hernandez, Julian Garcia-Feijoo, Federico Saenz-Frances, Enrique Santos-Bueso, Jose Maria Martinez-de-la-Casa, Alicia Valverde Megias, Ana M Fern&aacute;ndez-Vidal, Julian Garcia-SanchezOphthalmology Department, Hospital Clinico San Carlos de Madrid, Madrid, SpainPurpose: To assess the course of intraocular pressure (IOP), visual field progression, and adverse effects of antiglaucoma medication used during pregnancy.Methods: Thirteen eyes of eight patients with glaucoma were examined. Their clinical records were reviewed to compare IOP, number of medications, and visual field indices (VFI) before, during, and after pregnancy using a two-tailed paired t-test.Results: In seven (87.5%) of the eight patients, no disease progression was observed. IOP (mmHg) remained stable (baseline 17.3 &plusmn; 3.6; first trimester 17.4 &plusmn; 5.2, P = 0.930; second trimester 18.1 &plusmn; 4.7, P = 0.519; third trimester 20.2 &plusmn; 8.7, P = 0.344; and postpartum 21.5 &plusmn; 7.6, P = 0.136). The mean number of glaucoma treatments fell from 1.7 &plusmn; 0.52 before pregnancy to 0.83 &plusmn; 0.75 (P = 0.04) in the second and third trimesters. In one patient, IOP increased during pregnancy and there was further visual field loss. In the only patient kept on fixed combination timolol&ndash;dorzolamide therapy throughout pregnancy, labor was induced because of delayed intrauterine growth.Conclusions: No changes in IOP and VFI were detected in most patients despite a reduction in the number of hypotensive agents required. Delayed intrauterine growth in one patient under fixed combination timolol&ndash;dorzolamide treatment was observed whereas no other adverse effects were detected.Keywords: intraocular pressure, antiglaucoma medication, glaucoma, pregnancy, breast-feeding, adverse effects
format	article
author	Mendez-Hernandez C Garcia-Feijoo J Saenz-Frances F Santos-Bueso E Martinez-de-la-Casa JM Valverde Megias A Fern&aacute;ndez-Vidal AM Garcia-Sanchez J
author_facet	Mendez-Hernandez C Garcia-Feijoo J Saenz-Frances F Santos-Bueso E Martinez-de-la-Casa JM Valverde Megias A Fern&aacute;ndez-Vidal AM Garcia-Sanchez J
author_sort	Mendez-Hernandez C
title	Topical intraocular pressure therapy effects on pregnancy
title_short	Topical intraocular pressure therapy effects on pregnancy
title_full	Topical intraocular pressure therapy effects on pregnancy
title_fullStr	Topical intraocular pressure therapy effects on pregnancy
title_full_unstemmed	Topical intraocular pressure therapy effects on pregnancy
title_sort	topical intraocular pressure therapy effects on pregnancy
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/7a2e05875b42426aaa30053442c270d2
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Topical intraocular pressure therapy effects on pregnancy

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